Unfavorable Value Research Articles

Arthroscopic lateral acromion resection (ALAR) optimizes rotator cuff tear relevant scapula parameters

The acromion index (AI), critical shoulder angle (CSA) and lateral acromion angle (LAA) are predictive for degenerative rotatory cuff tears. Their unfavorable values are associated with a suboptimal deltoid force vector. The aim of this study was to evaluate whether an optimization of the radiological parameters could be achieved through a specific arthroscopic lateral acromion resection (ALAR). The procedure was performed in eight fresh frozen cadaver shoulders. True a.p. and axial radiographs were taken before and after the intervention for radiological evaluation. The anterior and posterior acromion edges were marked with a spinal needle. Then 1cm of the lateral acromion was resected with a 5.0 acromionizer (Arthrex Inc., Naples, FL, USA) beginning from the anterior aspect. The resection was completed over the total width of 1cm from anterior to posterior. Finally the deltoid insertion was dissected via an open approach to ensure its integrity. The fluoroscopy images were evaluated regarding the pre- and postinterventional parameters AI, CSA and LAA. After the intervention, the mean AI could be significantly reduced from 0.62±0.11 to 0.40±0.15 (p=0.012). Also the mean CSA was significantly reduced from 35.0°±7.65° to 25.12°±8.29° (p=0.018). The LAA could not be significantly changed (76.5°±14.02° vs. 82.13±8.93; p=0.107). There was no injury to the deltoid insertion. The radiographic parameters AI und CSA can be optimized significantly by ALAR without macroscopic discontinuity of the deltoid insertion. Level IV, case series without comparison group.

Clinicopathological Differences and Prognostic Value of Hypoxia-Inducible Factor-2α Expression for Gastric Cancer: Evidence From Meta-Analysis.

Published literatures have reported the relationship between hypoxic-inducible factor-2α (HIF-2α) expression and clinicopathological features in gastric cancer (GC), but the evaluated conclusions remain controversial.A meta-analysis was carried to examine the clinicopathological features and prognostic values of HIF-2α in patients with GC. Systematic detailed searches were performed to Pub Med, Cochrane Library, and EBSCO until to August 2015.Six studies (508 specimens) were included in this meta-analysis. HIF-2α-positive expression indicates an unfavorable prognosis value and advanced clinicopathological differences for the available patient dates with GC. Further multivariate meta-analysis revealed that HIF-2α-positive expression in gastric cancer associated with deeper tumor infiltration (OR = 3.08; 95%CI: 1.18–8.04), higher rates of lymphatic metastasis (OR = 3.26; 95%CI: 1.10–9.63), higher TNM stage (III+IV) (OR = 2.61; 95%CI: 1.40–4.84), and much lower 5-year overall survival (OR = 2.08; 95%CI: 1.21–3.58). Nevertheless, there is no association between HIF-2α-positive expression and worse tumor differentiation (OR = 2.03; 95%CI: 0.73–5.64). In addition, by this subgroup analysis, HIF-2α-positive expression associated with deeper tumor infiltration (OR = 3.81; 95%CI: 1.03–14.08), higher lymphatic metastasis (OR = 4.71; 95%CI: 1.08–20.50), higher TNM stage (OR = 3.21; 95%CI: 1.57–6.57), worse tumor differentiation (OR = 3.08; 95%CI: 1.51–6.31), and lower 5-year overall survival (OR = 2.34; 95%CI: 1.15–4.79).Our results indicate that HIF-2α overexpression can potently predict the poor prognosis and may be a potential therapeutic target for gastric carcinoma, according to the limited evidence. Meanwhile, further studies are needed to elucidate the accuracy of these results.

Quantitative Assessment of the Portal Pressure for the Liver Surgery Using Serological Tests

Objective:To establish a reliable equation to predict hepatic venous pressure gradient (HVPG) using serological tests for surgical patients with hepatocellular carcinoma (HCC).Background:Accurate assessment of portal pressure for surgical patients with HCC is important for safe hepatic resection (HR). The HVPG is regarded as the most reliable method to detect portal hypertension. However, HVPG is not utilized in many medical centers due to invasiveness of procedure.Methods:Between 2006 and 2008, 171 patients (Correlation cohort), who underwent liver surgery in a tertiary hospital, were enrolled. Preoperative measurements of the HVPG and serological tests were performed simultaneously. Correlation between the HVPG and serological tests were analyzed to establish an equation for calculated HVPG (cHVPG). Between 2008 and 2013, 510 surgical patients (Application cohort) were evaluated, and HR recommended when cHVPG < 10 mm Hg. The outcomes of HR were analyzed to evaluate reliability of the cHVPG for HR.Results:In the correlation cohort, the equation for cHVPG was established using multivariate linear regression analysis; cHVPG (mm Hg) = 0.209 × [ICG-R15 (%)] − 1.646 × [albumin (g/dL)] − 0.01×[platelet count (103)] + 1.669 × [PT-INR] + 8.911. In the application cohort, 425 patients with cHVPG < 10 mm Hg underwent HR. Among them, 357 had favorable value of ICG-R15 < 20% (group A), and 68 had unfavorable value of ICG-R15 ≥ 20% (group B). There was no significant difference in patient demographics, tumor characteristics, operative outcome, and survival rates between group A and B.Conclusions:The equation for cHVPG of this study was established on statistical reliability. The cHVPG could be useful to predict portal pressure quantitatively for surgical patients with HCC using serological tests.

Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer.

Reduced nuclear p27 expression is associated with a poor outcome in various cancers, including non-small cell lung cancer (NSCLC). Cytoplasmic p27 expression was shown to be associated with an unfavorable response to chemotherapy and poor outcomes in some carcinomas, but it has not been well studied in NSCLC. Herein, p27 expression in 219 tumors surgically resected from NSCLC patients was evaluated by immunohistochemistry (IHC). The most common of p27 immunostaining in lung tumors was observed in the cytoplasm (N-/C+, 32%), followed by negative (N-/C-, 29%), nucleus (N+/C-, 24%), and nucleus plus cytoplasm (N+/C+, 15%). Kaplan-Meier and Cox regression models showed that p27 N-/C+ tumors exhibited the worst overall survival (OS) and relapse-free survival (RFS) among the four categories of tumors. Among 135 of 219 patients who received cisplatin-based chemotherapy, p27 N-/C+ tumors most commonly showed an unfavorable response to cisplatin-based chemotherapy, followed by p27 N-/C- tumors when p27 N+/C- tumors were used as a reference. IHC analysis for phosphorylated extracellular signal-regulated kinase (p-ERK) and Bcl-2 expression in the lung tumors was performed to test whether ERK activation could enhance p27 nuclear export and the expression of Bcl-2 to test whether ERK activation could enhance p27 nuclear export and Bcl-2 expression. The data showed that p-ERK expression was positively correlated with cytoplasmic p27 (N-/C+) and Bcl-2 expression in the lung tumors. Patients with high Bcl-2-expressing tumors treated with cisplatin-based chemotherapy showed unfavorable predictive values in a subset of this study population. Therefore, we suggest that cytoplasmic p27 (N-/C+) via ERK-activated Bcl-2 expression may predict an unfavorable response to cisplatin-based chemotherapy and poor outcomes in NSCLC.

Analyzing Organizational Structure based on 7s model of McKinsey

Aim of this research was investigating and analyzing organizational structure free zone of Qeshm based on 7 S of McKinsey. Current research was applicable as well as descriptive and surveying. Statistical of research included managers and experts of free zone of Qeshm. We used n order to determine of simple random sampling in order to determine type of statistical sample and we used Cohcaran in order to determine amount of statistical sample. Following, we used 84 people as statistical sample. We used questionnaire in order to measure tools of the research and reliability of research is tested by alpha Cronbach (0.848) and validity of research is determined by professor and experts. We used Kolmogorov-Smirinov and T-test and Freedman test in order to analyze data. Results of research indicated that organizational structure based on 7-S McKinsey. Result of research indicated that organizational structure based on 7-S McKinsey in free zone of Qeshm is unfavorable and common value, clerks and structure had the worst conditions. In according to findings of research, it is recommended that managers of free zone of Qeshm more pay attention to internal environment of organization and improvement of procedure.

La influencia del deporte como generador de valores personales y sociales

El propósito de este manuscrito, consiste en presentar los resultados de un proceso investigativo relacionado con la evaluación de los valores personales y sociales en jóvenes futbolistas en edades comprendidas entre 10 y 13 años de la ciudad de Ibagué. Para ello, se utilizó un instrumento validado, el cual fue objeto de comprobar anticipadamente su fiabilidad. Los hallazgos encontrados, corresponden a la existencia de diferentes tendencias y factores que afectan el comportamiento del niño, los cuales imposibilitan dejar ver en su totalidad los valores que caracterizan su temprana edad; no obstante, se revelaron ciertos elementos que logran develar un indudable patrón de conducta. La alternativa de respuesta para aquellos sujetos que están determinados por actitudes valorativas desfavorables, estaría representada en conocer primordialmente las causas que provocan sus cuestionables tipos de comportamiento.

Mapping Natura 2000 Habitat Conservation Status in a Pannonic Salt Steppe with Airborne Laser Scanning

Natura 2000 Habitat Conservation Status is currently evaluated based on fieldwork. However, this is proving to be unfeasible over large areas. The use of remote sensing is increasingly encouraged but covering the full range of ecological variables by such datasets and ensuring compatibility with the traditional assessment methodology has not been achieved yet. We aimed to test Airborne Laser Scanning (ALS) as a source for mapping all variables required by the local official conservation status assessment scheme and to develop an automated method that calculates Natura 2000 conservation status at 0.5 m raster resolution for 24 km2 of Pannonic Salt Steppe habitat (code 1530). We used multi-temporal (summer and winter) ALS point clouds with full-waveform recording and a density of 10 pt/m2. Some required variables were derived from ALS product rasters; others involved vegetation classification layers calculated by machine learning and fuzzy categorization. Thresholds separating favorable and unfavorable values of each variable required by the national assessment scheme were manually calibrated from 10 plots where field-based assessment was carried out. Rasters representing positive and negative scores for each input variable were integrated in a ruleset that exactly follows the Hungarian Natura 2000 assessment scheme for grasslands. Accuracy of each parameter and the final conservation status score and category was evaluated by 10 independent assessment plots. We conclude that ALS is a suitable data source for Natura 2000 assessments in grasslands, and that the national grassland assessment scheme can successfully be used as a GIS processing model for conservation status, ensuring that the output is directly comparable with traditional field based assessments.

Metabolic syndrome and heart failure: data from the FADOI CONFINE study

Approximately 20%-30% of the population in industrialized countries suffers from metabolic syndrome (MetS), a condition that may double the risk of diabetes mellitus and heart diseases in the normal population. Both MetS per se and its components increase the risk of atherosclerosis and acute coronary artery disease and heart failure (HF). We reviewed the data from a recent survey of patients admitted to Italian internal medicine wards due to chronic heart failure to ascertain the prevalence and the relationships between MetS and HF in real life patients. Our data shows that some risk factors for this syndrome (above all obesity) reflect a sort of Janus phenomenon in that they are well-recognized risk factors for HF in young people, but they lose their unfavorable predictive value in elderly patients with HF.

Combined effect of constant high voltage electrostatic field and variable frequency pulsed electromagnetic field on the morphology of calcium carbonate scale in circulating cooling water systems.

Research on scale inhibition is of importance to improve the heat transfer efficiency of heat exchangers. The combined effect of high voltage electrostatic and variable frequency pulsed electromagnetic fields on calcium carbonate precipitation was investigated, both theoretically and experimentally. Using energy dispersive spectrum analysis, the predominant phase was found to be CaCO(3). The formed crystal phases mainly consist of calcite and aragonite, which is, in part, verified by theory. The results indicate that the setting of water flow velocity, and high voltage electrostatic and variable frequency pulsed electromagnetic fields is very important. Favorable values of these parameters can have a significant anti-scaling effect, with 68.95% of anti-scaling ratio for scale sample 13, while unfavorable values do not affect scale inhibition, but rather promoted fouling, such as scale sample 6. By using scanning electron microscopy analysis, when the anti-scaling ratio is positive, the particle size of scale was found to become smaller than that of untreated sample and the morphology became loose. The X-ray diffraction results verify that the good combined effect favors the appearance and growth of aragonite and restrains its transition to calcite. The mechanism for scale reduction is discussed.

Prognostic value of Onodera's index in colorectal cancer survival

Onodera's prognostic nutritional index (OPNI), which is calculated using total lymphocyte count and serum albumin level, has been used as a marker of nutritional status, with its potential prognostic value in colorectal cancer having recently been postulated in Japan and China. There is still no data on the predictive value of OPNI in a Western population. A consecutive case series of 207 patients scheduled for colorectal cancer resection with curative intent was reviewed. Pre-treatment OPNI was calculated using the formula: [10 x serum albumin (g/dl) + 0.005 x lymphocytes/mm²]. OPNI values under 40 were considered low. Univariate and multivariate analysis were performed on survival curves, comparing cases with OPNI values less than, equal to or greater than 40 (Cox model, stepwise), in the overall series and in pTNM stage II. The median for clinical follow-up was 81 months (interquartile range 60-96). Twenty-six patients (12.6%) had a low OPNI (≤ 40). In the multivariate analysis, patients with low OPNI showed less favourable survival curves, both in the overall series: [p <0.001; HR = 3.16; 95% CI = 1.67-5.94] and in the 78 cases in pTNM stage II: [p <0.004; HR = 4.36; 95% CI = 1.61-11.76]. A low pre-treatment OPNI (<40) has an independent, unfavourable predictive value on survival in European patients with resected colorectal cancer, both in the overall series and in pTNM stage II.

Combining Value and Momentum

This paper considers several popular portfolio implementation techniques that maximize exposure to value and/or momentum stocks while taking into account transaction costs. Our analysis of long-only strategies illustrates how a strategy that simultaneously incorporates both value and momentum outperforms a strategy that combines pure-play value and momentum portfolios that are formed independently. There are two advantages of the simultaneous strategy. The first is the reduction in transaction costs; the second is better utilization of unfavorable value and momentum information in a long-only portfolio. Our analysis also addresses the optimal way to combine the faster-moving momentum signal with the slower-moving value signal.

Behandlung eines Patienten mit Diabetes mellitus Typ 2 und einer depressiven Störung

A 65-year-old man with type 2 diabetes mellitus and unfavorable metabolic values in combination with obesity and arterial hypertension and considerable psychosocial strains presented at a psychosomatic outpatient clinic. During the course of diagnostic sessions a problematic illness behavior as well as a depressive symptomatology that had developed after the death of his wife a few years earlier became apparent. DIAGNOSIS, THERAPY, COURSE: An avoidant illness behavior and a moderate depressive episode were diagnosed. Within a low threshold psychosomatic intervention an understanding of illness could be established and psychosocial barriers of diabetes therapy were reduced. The patient was able to outline achievable goals of his diabetes treatment and began their successful implementation. Within a stepped-care approach the patient could also be motivated for an inpatient psychosomatic treatment. During the course of treatment the patient experienced a remission from his depressive symptomatology and a notable improvement of metabolic values. With the help of a close cooperation between diabetes specific and psychotherapeutic treatment in psychosomatic outpatient clinics, patients with high blood glucose levels and comorbid depression can be enabled to gain a better understanding of their illness behavior and change it in their favor.

Reversion of Incommensurate Modulation in Cubic Lazurite: Example of Reversible Forced Equilibrium?

The sample of cubic lazurite, collected in the Baikal region, with incommensurately 3D modulated (ITM) structure has been studied by the method of high-temperature X-ray powder diffraction. At short time of annealing in high-temperature diffraction experiment the modulation recovery proceeds during cooling down the sample to room temperature. The identity of the period of both initial and recovered modulation demonstrates that the system has a structural memory. The acquired results are interpreted through comparison of thermal behavior of lazurite, sodalite and quartz structures. It is supposed that two kinetically different and thermally activated processes proceed under heating: 1) reversible framework expansion due to Si-O-Al angle increase, and 2) equalizing of periodic local distortions via the diffusion-controlled transfer of cage ions between adjacent subcells. The second process seems to be much slower than the first one, especially at lower temperatures. With increasing temperature, both processes are activated. However, the framework expands more rapidly than the cage clusters migrate, and the periodic distortions of the framework are aligned. Under lower temperatures, the framework shrinks and again accommodates to the configuration of cage cations (clusters), which may be changed at high temperature and sufficient time or may not at lower temperature, short time, unfavorable SO2 fugacity values. In the first case the modulation disappears entirely, while in the second case it arises again. The probable reason for ITM formation is the balance of counteracting energetic terms: the elastic strain energy of structure deformation and the energy of cluster ordering providing the state of forced equilibrium. The excess free energy due to structure distortion is compensated by the increment associated with the cluster ordering process. However, no significant variations in sulphur anion speciation for different degrees of modulation retention were observed by XPS S 2p. This may be due to the ordering of Na- and Ca-containing clusters rather than the clusters with different sulphur species. ITM reversion is considered as an example of reversible forced equilibrium with completely reproducible forcing factor.

Parametri stabilnosti prinosa zrna i komponenti prinosa hibrida kukuruza razlicitih FAO grupa zrenja

An objective evaluation of maize hybrids in intensive cropping systems requires identification not only of yield components and other agronomically important traits but also of stability parameters. Grain yield and its components were assessed in 11 maize hybrids with different lengths of growing season (FAO 300-700 maturity groups) using analysis of variance and regression analysis at three different locations in Western Serbia. The test hybrids and locations showed significant differences in grain yield, grain moisture content at maturity, 1,000-kernel weight and ear length. A significant interaction was observed between all traits and the environment. The hybrids with higher mean values of the traits, regardless of maturity group, generally exhibited sensitivity i.e. adaptation to more favourable environmental conditions as compared to those having lower mean values. Regression coefficient (bi) values for grain yield mostly suggested no significant differences relative to the mean. The medium-season hybrid gave high yields and less favourable values of stability parameters at most locations and in most years, as compared to mediumlate hybrids. As compared to medium-early hybrids, medium-late hybrids (FAO 600 and 700) mostly exhibited unfavourable values of stability parameters i.e. a specific response and better adaptation to favourable environmental conditions, and gave higher average yields. Apart from producing lower average yields, FAO 300 and 400 hybrids showed higher yield stability as compared to the other hybrids tested. Medium-late hybrids had higher yields and showed a better response to favourable environmental conditions compared to early-maturing hybrids. Therefore, they can be recommended for intensive cultural practices and low-stress environments. Due to their more favourable stability parameter values, medium-early hybrids can be recommended for low-intensity cultural practices and stressful environments.

Characterizing scale‐dependent community assembly using the functional‐diversity–area relationship

Phenotypic traits mediate organisms' interactions with the environment and determine how they affect and are affected by their biotic and abiotic milieu. Thus, dispersion of trait values, or functional diversity (FD) of a community can offer insights into processes driving community assembly. For example, underdispersion of FD suggests that habitat "filtering" of species with unfavorable trait values restricts the species that can exist in a particular habitat, while even spacing of FD suggests that interspecific competition, or biotic "sorting," discourages the coexistence of species with similar trait values. Since assembly processes are expected to vary as a function of spatial scale, we should also expect patterns of FD to reflect scale dependence in filtering and biotic sorting. Here we present the concept of the functional-diversity-area relationship (FAR), which is similar to the species-area relationship but plots a measure of phenotypic trait diversity as a function of spatial scale. We develop a set of null model tests that discriminate between FARs generated predominantly by filtering or biotic sorting and indicate the scales at which these effects are pronounced. The utility of the FAR for addressing long-standing issues in ecology is illustrated with several examples. A multi-scale examination of FD and its pattern relative to null expectations provides an important tool for ecologists interested in understanding the scale dependence of community assembly processes.

Resolving the octant of θ 23 with T2K and NOνA

Preliminary results of MINOS experiment indicate that theta23 is not maximal. Global fits to world neutrino data suggest two nearly degenerate solutions for theta23: one in the lower octant (LO: theta23 < 45 degree) and the other in the higher octant (HO: theta23 > 45 degree). numu to nue oscillations in superbeam experiments are sensitive to the octant and are capable of resolving this degeneracy. We study the prospects of this resolution by the current T2K and upcoming NOvA experiments. Because of the hierarchy-deltacp degeneracy and the octant-deltacp degeneracy, the impact of hierarchy on octant resolution has to be taken into account. As in the case of hierarchy determination, there exist favorable (unfavorable) values of deltacp for which octant resolution is easy (challenging). However, for octant resolution the unfavorable deltacp values of the neutrino data are favorable for the anti-neutrino data and vice-verse. This is in contrast to the case of hierarchy determination. In this paper, we compute the combined sensitivity of T2K and NOvA to resolve the octant ambiguity. If sin^2\theta23 =0.41, then NOvA can rule out all the values of theta23 in HO at 2 sigma C.L., irrespective of the hierarchy and deltacp. Addition of T2K data improves the octant sensitivity. If T2K were to have equal neutrino and anti-neutrino runs of 2.5 years each, a 2 sigma resolution of the octant becomes possible provided sin^2\theta23 \leq 0.43 or \geq 0.58 for any value of deltacp.

Wind tunnel investigation of wind loads on rooftop model modules for green roofing systems

With the increasing popularity of modular green roofing systems, a need was perceived to establish building code requirements for these systems, such as wind resistant performance. However, few wind-related scientific researches have been conducted for such systems. In order to improve knowledge on wind load characteristics for green roof modules, a series of wind tunnel experiments were carried out on a scaled densely tapped module model installed at different positions on two types of flat roofs of medium-rise buildings. Peak force and moment coefficients of the rooftop module model were mainly investigated followed by comparison with related contents in ASCE/SEI7-10. The effect of parapets and other design parameters were also considered. The results show that the most unfavorable values for both peak lateral and uplift force coefficients occur when the module is located at the corners of the roof, and they exceed those suggested in the code. The overturning moments for the module are mainly determined by the uplift forces due to the unique geometry of green roof modules. The wind load decreases as the parapet height increases. For practical design, considerations on relating roof pressures to uplift forces, generalization of aerodynamic centers and estimation of failure wind speeds were proposed.

Potential of optimized NOνA for large [formula omitted] and combined performance with a LArTPC and T2K

NOνA experiment has reoptimized its event selection criteria in light of the recently measured moderately large value of θ13. We study the improvement in the sensitivity to the neutrino mass hierarchy and to leptonic CP violation due to these new features. Addition of 5 years of neutrino data from T2K to NOνA more than doubles the range of δCP for which the leptonic CP violation can be discovered, compared to stand alone NOνA. But for unfavorable values of δCP, the combination of NOνA and T2K are not enough to provide even a 90% C.L. hint of hierarchy discovery. Therefore, we further explore the improvement in the hierarchy and CP violation sensitivities due to the addition of a 10 kt liquid argon detector placed close to NOνA site. The capabilities of such a detector are equivalent to those of NOνA in all respects. We find that combined data from 10 kt liquid argon detector (3 years of ν + 3 years of ν¯ run), NOνA (6 years of ν + 6 years of ν¯ run) and T2K (5 years of ν run) can give a close to 2σ hint of hierarchy discovery for all values of δCP. With this combined data, we can achieve CP violation discovery at 95% C.L. for roughly 60% values of δCP.

Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index

BackgroundThe aim was to evaluate the metabolic profile in conjunction with vascular function using the ambulatory arterial stiffness index (AASI) in women with uncomplicated pregnancies and in women with gestational diabetes mellitus (GDM).MethodsPlasma glucose, lipids, HOMA –IR (homeostasis model assessment of insulin resistance) and AASI, as obtained from 24-hour ambulatory blood pressure monitoring in third trimester pregnancy and at three months postpartum, were measured in three groups of women: controls (N = 32), women with GDM on diet (N = 42) and women with GDM requiring insulin treatment (N = 10).ResultsWomen with GDM had poorer glycemic control and higher HOMA-IR during and after pregnancy and their total and LDL (low density lipoprotein) cholesterol levels were significantly higher after pregnancy than in the controls. After delivery, there was an improvement in AASI from 0.26 ± 0.10 to 0.17 ± 0.09 (P = 0.002) in women with GDM on diet, but not in women with GDM receiving insulin whose AASI tended to worsen after delivery from 0.30 ± 0.23 to 0.33 ± 0.09 (NS), then being significantly higher than in the other groups (P = 0.001-0.047).ConclusionsWomen with GDM had more unfavorable lipid profile and higher blood glucose values at three months after delivery, the metabolic profile being worst in women requiring insulin. Interestingly, the metabolic disturbances at three months postpartum were accompanied by a tendency towards arterial stiffness to increase in women requiring insulin.

Potential of optimized NOνA for large θ 13 &amp; combined performance with a LArTPC &amp; T2K

NOvA experiment has reoptimized its event selection criteria in light of the recently measured moderately large value of theta(13). We study the improvement in the sensitivity to the neutrino mass hierarchy and to leptonic CP violation due to these new features. For favourable values of deltacp, NOvA sensitivity to mass hierarchy and leptonic CP violation is increased by 20%. Addition of 5 years of neutrino data from T2K to NOvA more than doubles the range of deltacp for which the leptonic CP violation can be discovered, compared to stand alone NOvA. But for unfavourable values of deltacp, the combination of NOvA and T2K are not enough to provide even a 90% C.L. hint of hierarchy discovery. Therefore, we further explore the improvement in the hierarchy and CP violation sensitivities due to the addition of a 10 kt liquid argon detector placed close to NOvA site. The capabilities of such a detector are equivalent to those of NOvA in all respects. We find that combined data from 10 kt liquid argon detector (3 years of nu + 3 years of nubar run), NOvA (6 years of nu + 6 years of nubar run) and T2K (5 years of nu run) can give a close to 2 sigma hint of hierarchy discovery for all values of deltacp. With this combined data, we can achieve CP violation discovery at 95% C.L. for roughly 60% values of deltacp.