Conventional under-frequency and under-voltage load shedding schemes are known as effective approaches for load shedding purposes. Generally, these two schemes are deployed independently within which the combinatorial disturbances are overlooked. Contributing to this context, the ongoing study raises a high concern on developing a generalized wide-area adaptive load shedding scheme. In order to preserve the voltage and frequency stabilities, the established approach deploys the variations of voltage, frequency, active, and reactive power in all buses, simultaneously. More specifically, the reactive power variation on voltage stability is incorporated in the proposed load shedding index. This idea improves the performance of the proposed scheme, significantly. Infield phasor measurement units are establishing a wide-area basis, enabling the proposed approach in modern control centers. Extensive numerical studies are devised to assess the performance of the proposed approach encountering various disturbances. The obtained results are discussed in depth.