Each country of the world have to achieve sustainable development goals by 2030, is the main development agenda of the United Nations. There is an interconnection between millennium development goals and sustainable development goals which have some of the variables are similar. The development of the National Multidimensional Poverty Index of India is an important contribution towards instituting a public policy tool which monitors multidimensional poverty, informs evidence-based and focused interventions, thereby ensuring that no one is left behind In this connection, Recently, Poverty is being measured by taking some non monetary parameters and found its intensity and incidence of poverty. Similarly other goals can be analysed and Therefore, the study computes multidimensional deprivation index for each district in marathwada region and compare its deprivation level also. Multidimensional deprivation index is calculated on the basis of major three key components; health, education and standard of living in which two sub factors from education, four factors from living standard and twenty sub factors from health are considered. For measuring multidimentional deprivation index, the study has taken the reference of multidimentional poverty index which is developed by Sabina Alkire and James Foster in 2010. The study also identifies the factors which influences on their deprivation level. Due to unavailability of proper data the study has used and collected statistical data from National Family Health Survey-5 (2019-20). Weight to each parameter and deprivation level is determined in accordance with alkire-foster method. In this connection, the study finds that hingoli and parbhani districts are worst in comparison with other districts in marathwada in terms of health, education and living standard; followed by Jalna and Nanded.