Blade wear is the critical problem in the operation of multiphase pump. This paper presents a numerical study of the multiphase flow of multiphase pump. The trajectory of particles in the pump is calculated by the discrete phase model. Then, the simulation results are compared with the model test results of the pump to verify the correctness of the simulation method. The results show that the particles in the impeller domain are mainly near the hub, and the particles in the diffuser domain form a agglomerated area in the middle of the flow channel. The average wear rate of the impeller is more affected by the particle size than that of the diffuser. The maximum wear rate of blade surface increases first and then decreases with the increase of particle size. According to the wear data under different particle sizes, the regression model between particle size and wear rate is fitted to predict the wear of mixed transport pump in actual operation. The research results have important reference value for the prediction of the wear performance of the multiphase pump.