Resonant vibration condition involves a drop in the life-cycle of the components and is one of the main causes of high cycle fatigue failure (HCF) in turbomachinery blades. As a consequence vibration damping techniques play a key role for turbomachinery designers. Even though resonant vibration conditions can be identified by means of the Singh’s Advanced Frequency Evaluation (SAFE) diagram at the design level, not all resonant conditions can be avoided. Among these methods, systems of piezoelectric (PZT) actuators can be tuned to actively damp the vibrations caused by resonant excitations. In this work, an analytical model was developed to identify the optimal voltage distribution that maximises the reduction in blade stress. The model considers the flexural–torsional–extensional deformations coupling due to the pre-twisting, non-constant cross-section and inertial loads of the rotating blades. A typical case was examined to demonstrate the effectiveness of the proposed method, which involved vibration induced by inlet flow distortion in an axial fan stage coupled with a three-strut front frame. A decoupled approach based on Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) simulations was used to evaluate the aerodynamic loads and to numerically validate the optimal voltage distribution on the PZT actuator pairs. The results show that the proposed method alleviates the effects of the resonant response to an inlet flow distortion on a fan integrally bladed disc (blisk) and the optimal voltage distribution predicted by the model is the one that achieves the highest blade stress mitigation.