Tumor Pixels Research Articles

Segmentation of MR images for brain tumor detection using autoencoder neural network

Medical images often require segmenting into different regions in the first analysis stage. Relevant features are selected to differentiate various regions from each other, and the images are segmented into meaningful (anatomically significant) regions based on these features. The purpose of this study is to present a model for segmenting and identifying the local tumor formation in MR images of the human brain. The proposed system operates in an unsupervised manner to minimize the intervention of expert users and to achieve an acceptable speed in the tumor classification process. The proposed method includes several steps of preprocessing for different brain image classify that Perform the normalization task. These preprocessing steps lead to more accurate results in high-resolution images and ultimately improve the accuracy and sensitivity of tumor separation from brain tissue. The output of this stage is applied to a self-encoding neural network for image zoning. By nature of self-encoding networks, leads to reduce the dimensionality of tumor pixels from the surrounding healthy environment, which significantly helps remove regions incorrectly extracted as tumors. Finally, by extracting features from the previous stage's output through Otsu thresholding, the surrounding area and type of tumor are also extracted. The proposed method was trained and tested using the BRATS2020 database and evaluated by various performance metrics. The results based on the Dice Similarity Coefficient (DSC) show an accuracy of 97% for the entire MR image and improved detection accuracy compared to other methods, as well as a reduction in the cost of the diagnostic process.

Application of U-Net Network Utilizing Multiattention Gate for MRI Segmentation of Brain Tumors.

Studies have shown that the type of low-grade glioma is associated with its shape. The traditional diagnostic method involves extraction of the tumor shape from MRIs and diagnosing the type of glioma based on corresponding relationship between the glioma shape and type. This method is affected by the MRI background, tumor pixel size, and doctors' professional level, leading to misdiagnoses and missed diagnoses. With the help of deep learning algorithms, the shape of a glioma can be automatically segmented, thereby assisting doctors to focus more on the diagnosis of glioma and improving diagnostic efficiency. The segmentation of glioma MRIs using traditional deep learning algorithms exhibits limited accuracy, thereby impeding the effectiveness of assisting doctors in the diagnosis. The primary objective of our research is to facilitate the segmentation of low-grade glioma MRIs for medical practitioners through the utilization of deep learning algorithms. In this study, a UNet glioma segmentation network that incorporates multiattention gates was proposed to address this limitation. The UNet-based algorithm in the coding part integrated the attention gate into the hierarchical structure of the network to suppress the features of irrelevant regions and reduce the feature redundancy. In the decoding part, by adding attention gates in the fusion process of low- and high-level features, important feature information was highlighted, model parameters were reduced, and model sensitivity and accuracy were improved. The network model performed image segmentation on the glioma MRI dataset, and the accuracy and average intersection ratio (mIoU) of the algorithm segmentation reached 99.7%, 87.3%, 99.7%, and 87.6%. Compared with the UNet, PSPNet, and Attention UNet network models, this network model has obvious advantages in accuracy, mIoU, and loss convergence. It can serve as a standard for assisting doctors in diagnosis.

Brain Tumor Detection Using Classification Model

This study aims to develop automated methods for detecting and segmenting brain tumors in MRI scans using neural networks and conventional image processing. Accurately identifying tumor location and boundaries is crucial for diagnosis and determining the most effective treatment approach. Manual review by radiologists is time-consuming and subjective. However, recent advances in deep learning now enable more efficient analysis of large MRI datasets.
 A variety of neural network models have been explored for tumor segmentation, including recurrent networks, autoencoders and convolutional networks. RNNs are well-suited to capture contextual information across sequential MRI slices. Autoencoders perform unsupervised feature learning from the images. CNNs have shown promise due to their ability to directly learn visual patterns from pixel values. Unsupervised clustering techniques such as fuzzy c-means and k-means are also investigated to group tumor pixels based on intensity similarity without labeled data.
 Previous research combining these techniques has achieved high segmentation accuracy between 84-97% using additional image processing steps. Automated segmentation provides benefits over manual inspection such as reduced workload and more consistent delineation of tumor margins. It can precisely outline growths to aid radiologists in diagnosis and pathologists in assessing malignancy.
 The detection and segmentation of brain tumors has applications in both radiology and oncology. Radiologists could benefit from faster scan review and automated report generation. Neurosurgeons would gain insights into a tumor's size, location and infiltration to determine the most suitable surgical approach. Oncologists could utilize quantitative tumor features to select the most targeted radiation therapy or chemotherapy protocols. Overall, continued advances in deep and machine learning hold promise to improve diagnosis and management of brain cancer patients.

Brain tumor detection based on a novel and high-quality prediction of the tumor pixel distributions

The work presented in this paper is in the area of brain tumor detection. We propose a fast detection system with 3D MRI scans of Flair modality. It performs 2 functions, predicting the gray level distribution and location distribution of the pixels in the tumor regions and generating tumor masks with pixel-wise precision. To facilitate 3D data analysis and processing, we introduce a 2D histogram presentation encompassing the gray-level distribution and pixel-location distribution of a 3D object. In the proposed system, specific 2D histograms highlighting tumor-related features are established by exploiting the left-right asymmetry of a brain structure. A modulation function, generated from the input data of each patient case, is applied to the 2D histograms to transform them into coarsely or finely predicted distributions of tumor pixels. The prediction result helps to identify/remove tumor-free slices. The prediction and removal operations are performed to the axial, coronal and sagittal slice series of a brain image, transforming it into a 3D minimum bounding box of its tumor region. The bounding box is utilized to finalize the prediction and generate a 3D tumor mask. The proposed system has been tested extensively with the data of more than 1200 patient cases in BraTS2018∼2021 datasets. The test results demonstrate that the predicted 2D histograms resemble closely the true ones. The system delivers also very good tumor detection results, comparable to those of state-of-the-art CNN systems with mono-modality inputs. They are reproducible and obtained at an extremely low computation cost and without need for training.

An improved semantic segmentation for breast lesion from dynamic contrast enhanced MRI images using deep learning

AbstractThe World Health Organization (WHO) reports that approximately 2.3 million breast cancer cases are diagnosed each year. Early detection is key to tackling this issue, and Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) is a preferred method for detecting tumors. Convolutional Neural Networks (CNNs) can accurately segment images without human assistance. The objective of this study is to develop a computer‐aided diagnosis system that can segment breast lesions from DCE‐MRI images. A 92‐layer deep CNN, called DCNN‐92, and a 94‐layer deep CNN, called DCNN‐94, have been designed to identify lesions. The proposed methods have been validated using images from The Cancer Image Archive (TCIA) database. The proposed DCNN‐92 model segments the tumor pixels effectively, but it exhibits some misclassifications where certain background pixels are incorrectly labeled as tumor and tumor pixels are identified as background. To segment the tumor pixels more accurately, two grouped convolution layers are added to the DCNN‐92 model. The model with 94 layers, that is, DCNN‐94, segments most of the tumor pixels correctly, thereby enhancing the segmentation performance. When compared to DCNN‐92, the DCNN‐94 model exhibits enhanced performance across standard metrics such as sensitivity, dice coefficient, Jaccard coefficient, and area under the curve (AUC). It was found that the training time for DCNN‐94 is shorter. The DCNN‐94 model with dilation factor and group convolution is concluded to be an effective method for lesion segmentation from breast DCE‐MRI images compared to existing methods.

MAEU‐NET: A novel supervised architecture for brain tumor segmentation

AbstractA brain tumor is an abnormal growth of cells that damages the neural system and may lead to severe conditions. These cells are irregular in shape and size, and as a result, the manual analysis of these cells from magnetic resonance (MR) images is a cumbersome and time‐consuming task. To alleviate these issues, a novel U‐Net inspired MAEU‐Net (Multiscale context Aggregation and Edge activation U‐Net) is implemented to detect the brain tumor pixels from MR images more precisely. The encoder block of the proposed model is improved by integrating with multiscale feature aggregation and convolution block attention modules (CBAM) enabling the model to extract both pertinent low‐level and high‐level features. Further, the extracted features are subjected to a parallel pooling module to elevate the features that extract the tumor pixels. In addition to this, the output features of the last encoder are fed to a parallel dilated context aggregation module to mitigate the hyper‐parameter size and further elevate the receptive field strength of the proposed model. Apart from this, edge‐enhanced modules are incorporated with skip connections which concatenate the feature maps of the decoder with respective edge‐enhanced encoder feature maps. As a result, this module increases the aspect ratio and reduces blurry edge problems. To illustrate the performance of the proposed MAEU‐Net, it is trained and tested using Kaggle LGG, BraTS 2018, and BraTS 2021 publicly available datasets. The proposed model outperformed the previously existing models by achieving the test loss, dice coefficient, sensitivity, and specificity of 0.0590, 0.901, 0.942, and 0.998, respectively. Simultaneously, the proposed model is quantitatively analyzed by performing ablation and comparative studies and presented that the proposed MAEU‐Net is superior to other previous existing models like U‐Net++, SegNet, etc.

Meningioma brain tumor detection and classification using hybrid CNN method and RIDGELET transform

The detection of meningioma tumors is the most crucial task compared with other tumors because of their lower pixel intensity. Modern medical platforms require a fully automated system for meningioma detection. Hence, this study proposes a novel and highly efficient hybrid Convolutional neural network (HCNN) classifier to distinguish meningioma brain images from non-meningioma brain images. The HCNN classification technique consists of the Ridgelet transform, feature computations, classifier module, and segmentation algorithm. Pixel stability during the decomposition process was improved by the Ridgelet transform, and the features were computed from the coefficient of the Ridgelet. These features were classified using the HCNN classification approach, and tumor pixels were detected using the segmentation algorithm. The experimental results were analyzed for meningioma tumor images by applying the proposed method to the BRATS 2019 and Nanfang dataset. The proposed HCNN-based meningioma detection system achieved 99.31% sensitivity, 99.37% specificity, and 99.24% segmentation accuracy for the BRATS 2019 dataset. The proposed HCNN technique achieved99.35% sensitivity, 99.22% specificity, and 99.04% segmentation accuracy on brain Magnetic Resonance Imaging (MRI) in the Nanfang dataset. The proposed system obtains 99.81% classification accuracy, 99.2% sensitivity, 99.7% specificity and 99.8% segmentation accuracy on BRATS 2022 dataset. The experimental results of the proposed HCNN algorithm were compared with those of the state-of-the-art meningioma detection algorithms in this study.

Detection of meningioma tumor images using Modified Empirical Mode Decomposition (MEMD) and convolutional neural networks

The meningioma brain tumor detection is more important than the other tumor detection such as Glioma and Glioblastoma, due to its high severity level. The tumor pixel density of meningioma tumor is high and it leads to sudden death if it is not detected timely. The meningioma images are detected using Modified Empirical Mode Decomposition- Convolutional Neural Networks (MEMD-CNN) classification approach. This method has the following stages data augmentation, spatial-frequency transformation, feature computations, classifications and segmentation. The brain image samples are increased using data augmentation process for improving the meningioma detection rate. The data augmented images are spatially transformed into frequency format using MEMD transformation method. Then, the external empirical mode features are computed from this transformed image and they are fed into CNN architecture to classify the source brain image into either meningioma or non-meningioma. The pixels belonging tumor category are segmented using morphological opening-closing functions. The meningioma detection system obtains 99.4% of Meningioma Classification Rate (MCR) and 99.3% of Non-Meningioma Classification Rate (NMCR) on the meningioma and non-meningioma images. This MEMD-CNN technique for meningioma identification attains 98.93% of SET, 99.13% of SPT, 99.18% of MSA, 99.14% of PR and 99.13% of FS. From the statistical comparative analysis of the proposed MEMD-CNN system with other conventional detection systems, the proposed method provides optimum tumor segmentation results.

Cancer Regions in Mammogram Images Using ANFIS Classifier Based Probability Histogram Segmentation Algorithm

Every year, the number of women affected by breast tumors is increasing worldwide. Hence, detecting and segmenting the cancer regions in mammogram images is important to prevent death in women patients due to breast cancer. The conventional methods obtained low sensitivity and specificity with cancer region segmentation accuracy. The high-resolution standard mammogram images were supported by conventional methods as one of the main drawbacks. The conventional methods mostly segmented the cancer regions in mammogram images concerning their exterior pixel boundaries. These drawbacks are resolved by the proposed cancer region detection methods stated in this paper. The mammogram images are classified into normal, benign, and malignant types using the Adaptive Neuro-Fuzzy Inference System (ANFIS) approach in this paper. This mammogram classification process consists of a noise filtering module, spatial-frequency transformation module, feature computation module, and classification module. The Gaussian Filtering Algorithm (GFA) is used as the pixel smooth filtering method and the Ridgelet transform is used as the spatial-frequency transformation module. The statistical Ridgelet feature metrics are computed from the transformed coefficients and these values are classified by the ANFIS technique in this paper. Finally, Probability Histogram Segmentation Algorithm (PHSA) is proposed in this work to compute and segment the tumor pixels in the abnormal mammogram images. This proposed breast cancer detection approach is evaluated on the mammogram images in MIAS and DDSM datasets. From the extensive analysis of the proposed tumor detection methods stated in this work with other works, the proposed work significantly achieves a higher performance. The methodologies proposed in this paper can be used in breast cancer detection hospitals to assist the breast surgeon to detect and segment the cancer regions.

BirCat Optimization for Automatic Segmentation of Brain Tumors and Pixel Change Detection Using Post-operative MRI Images.

There is an emerging need for medical imaging data to provide patients with timely diagnosis. Magnetic resonance imaging (MRI) images based on brain tumor segmentation approaches possess greater importance in planning treatment. Though, mechanizing the process with different imaging conditions and accuracy is a major challenge due to variations in tumor structures. Hence, an efficient optimization-driven classifier, called BirCat optimization-based deep belief network (BirCat-based DBN)isdeveloped to detect brain tumors. The introduced BirCat is devised by incorporating birdswarm algorithm (BSA) into cat swarm optimization (CSO) algorithm and is employed in tuning the DBN classifier. Here, the first step is pre-processing, where noises, as well as artifacts in input image, are eliminated by means of ROI extraction and filtering method. Then, for segmentation, region growing algorithm is used in which the distance is calculated by the modified Bhattacharya measure. Afterward, each segment is adapted for mining the segment-based features and pixel-based features used for classification. Then, the feature vector is formed and given to the DBN classifier, which is tuned with the help of the introduced BirCat for brain tumor detection. The introduced technique effectively determines the regions with the tumor in the input MRI image. Finally, the change detection is evaluated by analyzing the post-operative MRI image and the segmented image by means of pixel mapping strategy with respect to SURF features. The pixel mapping is utilized to evaluate the percentage change in tumor pixels. The proposed BirCat surpassed other prevailing approaches by producing maximal values of specificity, accuracy, sensitivity, F1-score, and Dice score at 0.92, 0.927, 0.938, 0.909, and 0.937, correspondingly, for dataset 2.

A novel depth search based light weight CAR network for the segmentation of brain tumour from MR images

In this modern era, brain tumour is one of the dreadful diseases that occur due to the growth of abnormal cells or by the accumulation of dead cells in the brain. If these abnormalities are not detected in the early stages, they lead to severe conditions and may cause death to the patients. With the advancement of medical imaging, Magnetic Resonance Images (MRI) are developed to analyze the patients manually. However, this manual screening is prone to errors. To overcome this, a novel depth search-based network termed light weight channel attention and residual network (LWCAR-Net) is proposed by integrating with a novel depth search block (DSB) and a CAR module. The depth search block extracts the pertinent features by performing a series of convolution operations enabling the network to restore low-level information at every stage. On other hand, CAR module in decoding path refines the feature maps to increase the representation and generalization abilities of the network. This allows the network to locate the brain tumor pixels from MRI images more precisely. The performance of the depth search based LWCAR-Net is estimated by testing on different globally available datasets like BraTs 2020 and Kaggle LGG dataset. This method achieved a sensitivity of 95%, specificity of 99%, the accuracy of 99.97%, and dice coefficient of 95% respectively. Furthermore, the proposed model outperformed the existing state-of-the-art models like U-Net++, SegNet, etc by achieving an AUC of 98% in segmenting the brain tumour cells.

Analysis on Methods for Detecting Brain Tumor from MRI images

Abstract: Brain tumor detection from MRI images is a challenging process due to high diversity in the tumor pixels of different peoples. Automatic detection has got wide spread acclaim because the manual detection by experts is time consuming and prone to error in judjement.Due to its high mortality rate, detection of tumor automatically is a new emerging technique in bio medical imaging. Here we present a review of few methods from simple threholding to advanced deep learning methods for segmentation of tumor from MRI data. The segmentation of tumor methods is classified to image segmentation using gray level processing, machine learning and deep learning. We compare the result of various method in an attempt to find the best methods available. As medical imaging methods have improving day by day we hope this review will help to understand emerging trends in brain tumor detection.

A Lightweight Hybrid Dilated Ghost Model-Based Approach for the Prognosis of Breast Cancer.

Most approaches use interactive priors to find tumours and then segment them based on tumour-centric candidates. A fully convolutional network is demonstrated for end-to-end breast tumour segmentation. When confronted with such a variety of options, to enhance tumour detection in digital mammograms, one uses multiscale picture information. Enhanced segmentation precision. The sampling of convolution layers are carefully chosen without adding parameters to prevent overfitting. The loss function is tuned to the tumor pixel fraction during training. Several studies have shown that the recommended method is effective. Tumour segmentation is automated for a variety of tumour sizes and forms postprocessing. Due to an increase in malignant cases, fundamental IoT malignant detection and family categorisation methodologies have been put to the test. In this paper, a novel malignant detection and family categorisation model based on the improved stochastic channel attention of convolutional neural networks (CNNs) is presented. The lightweight deep learning model complies with tougher execution, training, and energy limits in practice. The improved stochastic channel attention and DenseNet models are employed to identify malignant cells, followed by family classification. On our datasets, the proposed model detects malignant cells with 99.3 percent accuracy and family categorisation with 98.5 percent accuracy. The model can detect and classify malignancy.

Deep Neural Network-Based Novel Mathematical Model for 3D Brain Tumor Segmentation

The use of multimodal magnetic resonance imaging (MRI) to autonomously segment brain tumors and subregions is critical for accurate and consistent tumor measurement, which can help with detection, care planning, and evaluation. This research is a contribution to the neuroscience research. In the present work, we provide a completely automated brain tumor segmentation method based on a mathematical model and deep neural networks (DNNs). Each slice of the 3D picture is enhanced by the suggested mathematical model, which is then sent through the 3D attention U-Net to provide a tumor segmented output. The study includes a detailed mathematical model for tumor pixel enhancement as well as a 3D attention U-Net to appropriately separate the pixels. On the BraTS 2019 dataset, the suggested system is tested and verified. This proposed work will definitely help for the treatment of the brain tumor patient. The pixel level accuracy for tumor pixel segmentation is 98.90%. The suggested system architecture's outcomes are compared to those of current system designs. This study also examines the suggested system architecture's time complexity on various processing units with neuroscience approach.

Abstract PD14-02: Unravelling spatial tumor organization and heterogeneity in lobular breast cancer using spatial transcriptomics

Abstract Introduction: Invasive lobular breast cancer (ILC) is the most frequent special type of breast cancer. Recent studies showed the impact of intratumor heterogeneity (ITH) on patient outcome. Here, we aimed to better characterize ITH in ILC using spatial transcriptomics (ST) together with high-resolution morphological annotation. Methods: Spatial transcriptomics (Visium 10x Genomics) was performed on frozen tumor samples from 15 primary estrogen receptor positive, HER2-negative ILCs with 4 patients developing disease relapse. For each sample, we annotated hematoxylin/eosin sections (QuPath software) in two steps: manual annotation of specific histomorphological structures (e.g. normal breast ducts, fat tissue, vessels) and machine learning annotation of stroma and tumor cells at the single cell level. Proportion of each specific tissue type per sample was defined by pixel percentage computed within each ST spot. For each sample, the proportion of a given tissue type was defined as the proportion of pixels annotated with this specific type averaged across all spots within the tissue section. Spatially variable genes were used as input for non-negative matrix factorization and the reduced expression matrix was clustered with the Louvain algorithm implemented in Seurat. A cluster of spots was defined as tumoral if the average proportion of pixels annotated as tumor across its constitutive spots was higher than the average proportion of tumor pixels across all spots from the tissue section. Cluster characterization was performed using gene set enrichment analysis based on hallmarks (Molecular Signature Database) with a false discovery rate < 0.05. Spatial heterogeneity and tumor organization within each sample were assessed according to the number and type of cluster interactions, homo-contacts being defined as interactions between spots belonging to the same cluster and hetero-contacts between spots from two different clusters. Comparisons between groups were assessed using Wilcoxon test. Results: A total of 45 tumor clusters were identified among the 15 patients, with a range of 2-4 tumor clusters per sample highlighting intra-tumor heterogeneity. Cluster characterization revealed the presence of clusters enriched in different biological pathways within a given sample. These analyses also showed inter-patient heterogeneity as witnessed by distinct tumor clusters only present in a subset of tissue samples. In particular, 66% (N=10/15) of the tissue samples harbored clusters enriched in oxidative phosphorylation, 53% (N=8/15) in epithelial-mesenchymal transition, 33% (N=5/15) in interferon gamma response, 27% (N=4/15) in TNF-alpha via NFkB, 27% (N=4/15) in androgen response and 13% (N=2/15) in protein secretion hallmarks. All samples shared at least one tumor cluster enriched in estrogen early and late response.Although the number of tumor clusters was similar between samples from patients with or without relapse (median of 3, range 2-4), the presence of clusters enriched in protein secretion was associated with disease recurrence (p = 0.02). Of note, higher number of hetero-contacts mirroring tumor disorganization was associated with poor outcome although not significant (p= 0.08). Conclusions: Here, we showed for the first time a substantial inter- and intra-tumor heterogeneity of ILC at an unprecedented level, characterized by the presence of specific tumor clusters and distinct tumor organization patterns associated with outcome. We also. uncovered potentially targetable clusters missed by bulk analysis, offering novel perspectives for optimized ILC care. Further validation is warranted. Citation Format: Laetitia Collet, Matteo Serra, Mattia Rediti, Frédéric Lifrange, David Venet, XiaoXiao Wang, Delphine Vincent, Ghizlane Rouas, Danai Fimereli, David Gacquer, Andrea Joaquin Garcia, Isabelle Veys, Ligia Craciun, Denis Larsimont, Miikka Vikkula, François Duhoux, Françoise Rothé, Christos Sotiriou. Unravelling spatial tumor organization and heterogeneity in lobular breast cancer using spatial transcriptomics [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD14-02.

An Efficient Approach to Detect Meningioma Brain Tumor Using Adaptive Neuro Fuzzy Inference System Method

Detection of tumors in brain on time saves the patient life. The brain tumor detection is usually done in Magnetic Resonance Imaging (MRI) of the human brain. An automated model is framed to identify tumor pixels in method for detecting and image. This proposed method contains the following modules as enhancement, transformation, feature extraction, classifications and segmentation. The Oriented Local Histogram Equalization (OLHE) method is applied on the brain MRI images in order to enhance the pixel intensity in boundary regions. This enhanced brain image is transformed to multi orientation image using Gabor transform with respect to various scale and orientation of pixels. Then, set of features (Higher Order Spectra (HOS), Gradient, Grey Level Co-occurrence Matrix (GLCM), Local Binary Pattern (LBP) and Curvelet) are extracted from this Gabor transformed image and these features are further trained and classified into benign or malignant using Adaptive Neuro Fuzzy Inference (ANFIS) classification approach. Finally, morphological algorithm is used for segmenting the tumor regions in the classified responses. MATLAB R2018 version is used in this paper to simulate the proposed algorithm for brain tumor detection. This proposed system achieves 98.6% of sensitivity, 99.5% of specificity and 99.4% of segmentation accuracy.

Mass Sphering Approach for Three-Dimensional Reconstruction of Brain Tumor using MRI

Objective: The objective of the research work is to reconstruct the brain tumor three-dimensionally with high degree of accuracy. Methods: This study describes 3D reconstruction of brain tumor using Mass Sphering Approach (MSA) algorithm. 39 weighted features are extracted from the non-tumor and tumor pixels. These weighted features are used to train the Support Vector Machine (SVM) algorithm. Number of training samples taken to train SVM algorithm are 268 and the testing sample are 64. The complete MR image set of a subject (64 axial slices) are detected for tumor pixels and these slices are concatenated to get volumetric tumor information. Findings: 5-step MSA algorithm is proposed which includes filtering, segmentation, classification, optimization and reconstruction. MR images are subjected to Rician noise which can be removed by a simple correction scheme, initiated to change the bias due to the Rician distribution of the noisy magnitude data. The filtered MR image slices are segmented and classified to detect the tumor areas and the tumor pixels are subjected for 3D reconstruction. The improvement in performance of MSA is depicted by comparing the algorithm with traditional SVM. Novelty: The accuracy achieved in detecting glioma and glioblastoma using MSA are 95.24% and 99% respectively which is highly remarkable. Keywords: Glioma; voxel; Magnetic Resonance; Classification; Immune; Reconstruction

Characterization of breast cancer subtypes based on quantitative assessment of intratumoral heterogeneity using dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging.

To investigate whether intratumoral heterogeneity, assessed via dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI), reflects the molecular subtypes of invasive breast cancers. We retrospectively evaluated data from 248 consecutive women (mean age ± standard deviation, 54.6 ± 12.2 years) with invasive breast cancer who underwent preoperative DCE-MRI and DWI between 2019 and 2020. To evaluate intratumoral heterogeneity, kinetic heterogeneity (a measure of heterogeneity in the proportions of tumor pixels with delayed washout, plateau, and persistent components within a tumor) was assessed with DCE-MRI using a commercially available computer-aided diagnosis system. Apparent diffusion coefficients (ADCs) were obtained using a region-of-interest technique, and ADC heterogeneity was calculated using the following formula: (ADCmax-ADCmin)/ADCmean. Possible associations between imaging-based heterogeneity values and breast cancer subtypes were analyzed. Of the 248 invasive breast cancers, 61 (24.6%) were classified as luminal A, 130 (52.4%) as luminal B, 25 (10.1%) as HER2-enriched, and 32 (12.9%) as triple-negative breast cancer (TNBC). There were significant differences in the kinetic and ADC heterogeneity values among tumor subtypes (p < 0.001 and p = 0.023, respectively). The TNBC showed higher kinetic and ADC heterogeneity values, whereas the HER2-enriched subtype showed higher kinetic heterogeneity values compared to the luminal subtypes. Multivariate linear analysis showed that the HER2-enriched (p < 0.001) and TNBC subtypes (p < 0.001) were significantly associated with higher kinetic heterogeneity values. The TNBC subtype (p = 0.042) was also significantly associated with higher ADC heterogeneity values. Quantitative assessments of heterogeneity in enhancement kinetics and ADC values may provide biological clues regarding the molecular subtypes of breast cancer. • Higher kinetic heterogeneity was associated with HER2-enriched and triple-negative breast cancer. • Higher ADC heterogeneity was associated with triple-negative breast cancer. • Aggressive breast cancer subtypes exhibited higher intratumoral heterogeneity based on MRI.

A frame work for the detection and Diagnosis of Lung Tumors using Deep learning Methods

The detection of tumor pixels in lung images is complex task due to its low contrast property. Hence, this paper uses deep learning architectures for both the detection and diagnosis of lung tumors in Computer Tomography (CT) images. In this article, the tumors are detected in lung CT images using Convolutional Neural Networks (CNN) architecture with the help of data augmentation methods. This proposed CNN architecture classifies the lung images into two categories as tumor images and normal images. Then, the segmentation method is used to segment the tumor pixels in the lung CT images and the segmented tumor regions are classified into either mild or severe using proposed CNN architecture.

Over 1000 nm Near-Infrared Multispectral Imaging System for Laparoscopic In Vivo Imaging.

In this study, a laparoscopic imaging device and a light source able to select wavelengths by bandpass filters were developed to perform multispectral imaging (MSI) using over 1000 nm near-infrared (OTN-NIR) on regions under a laparoscope. Subsequently, MSI (wavelengths: 1000–1400 nm) was performed using the built device on nine live mice before and after tumor implantation. The normal and tumor pixels captured within the mice were used as teaching data sets, and the tumor-implanted mice data were classified using a neural network applied following a leave-one-out cross-validation procedure. The system provided a specificity of 89.5%, a sensitivity of 53.5%, and an accuracy of 87.8% for subcutaneous tumor discrimination. Aggregated true-positive (TP) pixels were confirmed in all tumor-implanted mice, which indicated that the laparoscopic OTN-NIR MSI could potentially be applied in vivo for classifying target lesions such as cancer in deep tissues.