Purpose. The purpose of this study is to formation of a mechanism for the creation of a platform for innovative cooperation and the establishment of mutually beneficial economic relations between business entities and institutions of higher education (scientific institutions) for the development and implementation of innovations, stimulating investments in the modernization and technical re-equipment of the technical and technological base of industrial production at the regional level. Design/methodology/approach. In the article, the author used analysis, statistical, comparison, scenario, generalization, and abstract-logical methods in formulating conclusions and recommendations in order to justify the importance of forming a mechanism for creating a platform for innovative cooperation and establishing mutually beneficial economic relations between business entities and institutions of higher education (scientific institutions) for the development and implementation of technological innovations, and therefore, to justify the relevance of the chosen research topic. On the basis of the literature review, the author determined the goals of analyzing the indicators of innovative activity of industrial enterprises of the Lviv region and substantiated the main trends of socio-economic development of the Lviv region. The scenarios of the economic development of the Lviv Oblast considered by the author made it possible to form conclusions, the reliability of which is based on the interpretation of the indicators calculated in the analytical part. Findings. The hypothesis that the innovative model of the economy in modern conditions is characterized, first of all, by the readiness of the business entities forming it to compete, search for and develop new markets, has been proven. Achieving this state in industry at the regional level is possible only thanks to the introduction of technological innovations, entering the market with new knowledge-intensive, competitive products. Also, today’s requirement, in particular at the stage of the Russian-Ukrainian war, which is devastating for the national economy, is the creation of stimulating mechanisms adequate to the challenges of the times for investing in innovative technological processes, in the restoration of Ukrainian production on an innovative basis. The innovative and productive way of development of the region’s industry is connected with the implementation of the principles of narrow specialization in the region’s economy, comprehensive modernization, structural transformation not only of industry, but also of all major types of economic activity and their integration with the region’s innovative and scientific and educational systems. The main task of the mechanism of innovative cooperation is to stimulate the activity of scientists, researchers, innovators in cooperation with industrialists (entrepreneurs) to increase the level of scientific and technical and technical and technological achievements, increase innovative activity and the culture of interaction of the research and entrepreneurial spheres. Practical implications. The results of this study are of interest to higher education institutions, business entities and regional authorities, which seek to improve the level of the innovative environment of the region in accordance with the conditions of competitive markets and to ensure the stimulation of innovative and technological development of industrial enterprises. In addition, the results can help researchers of higher education institutions to improve the tools of dissemination of innovative knowledge, which are used to transform the business environment on the basis of technological innovation. Originality/value. This study emphasizes the peculiarities of innovative activity of industrial enterprises of Lviv region and the main trends of socio-economic development of Lviv region. The outline of the economic development scenarios of the Lviv Oblast made it possible to formulate principles and tasks regarding the regional stimulation of innovative activity. Provide recommendations to regional authorities regarding the mechanisms of competitive selection and co-financing of the implementation of innovative projects.