Treasure Trove Research Articles

A certified de-identification system for all clinical text documents for information extraction at scale.

Clinical notes are a veritable treasure trove of information on a patient's disease progression, medical history, and treatment plans, yet are locked in secured databases accessible for research only after extensive ethics review. Removing personally identifying and protected health information (PII/PHI) from the records can reduce the need for additional Institutional Review Boards (IRB) reviews. In this project, our goals were to: (1) develop a robust and scalable clinical text de-identification pipeline that is compliant with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule for de-identification standards and (2) share routinely updated de-identified clinical notes with researchers. Building on our open-source de-identification software called Philter, we added features to: (1) make the algorithm and the de-identified data HIPAA compliant, which also implies type 2 error-free redaction, as certified via external audit; (2) reduce over-redaction errors; and (3) normalize and shift date PHI. We also established a streamlined de-identification pipeline using MongoDB to automatically extract clinical notes and provide truly de-identified notes to researchers with periodic monthly refreshes at our institution. To the best of our knowledge, the Philter V1.0 pipeline is currently the first and only certified, de-identified redaction pipeline that makes clinical notes available to researchers for nonhuman subjects' research, without further IRB approval needed. To date, we have made over 130 million certified de-identified clinical notes available to over 600 UCSF researchers. These notes were collected over the past 40 years, and represent data from 2757016 UCSF patients.

Мәдениеттегі менеджмент және халықаралық мәдени кеңістікке интеграциялану

The article deals with scientific and practical research work on the issue of cultural management and integration into the international cultural space. In the modern era of globalization, friendship and respect, mutual understanding and cooperation between peoples and countries have been established, and, above all, it is important to establish cultural ties through knowledge, deepen the roots of cultural relations, taking into account scientific trust and mutual understanding. As the main characteristics of a globalized culture, which is being formed in the course of modern integration of cultures, the researchers of this issue consider the scale in a certain space, including the phenomena and cultural phenomena. Kazakhstan's cultural management in the context of globalization has entered into successful integration processes, it is important to determine, correctly coordinate special strategic steps. The main purpose of the article is to convey the influence and importance of cultural management and integration into the international cultural space. As a multinational state, if we can establish and protect our borders with a clear purpose, this will be one of the greatest achievements we have reached. Any state pays great attention to the protection of the above values, because it understands that from the state point of view, other institutions do not have the competence to resolve precisely these issues. Considering that the future consists of today, it is obvious that the growth rate of this industry is in our hands, and the industry is also one of the instruments for the existence of a new country, which in the future will not only spiritually strengthen the country, but also encourage us to move forward as an economic treasure trove. The main competence of the sphere of cultural management is not only the organization of the plan of cultural events throughout the republic, but also the promotion of cultural values

Value addition and bioprospecting of indigenous ethnic food, Amorphophallus bulbifer (Roxb.) Blume (Araceae) for sustainable livelihood

Tripura, a small hilly state in India, harbors a treasure trove of traditional knowledge that revolves around utilizing forest-based resources for sustenance. Amorphophallus bulbifer (Roxb.) Blume, which belongs to the family Araceae, is a widely available and preferred food choice for the ethnic communities in Tripura. This study aimed to look at its biochemical potential for adding value and for bioprospecting. Several markets and homes were polled to determine how they could be used for more than one thing and to estimate the wild stock, demand, and supply. The results revealed that the corm is processed to make a food cake known as Batema and has a high market value. Batema is a traditional food that is high in carbs and is sold in the local markets which are alternative to soybeans and tofu. Furthermore, the nutritional content analysis reveals that a higher proportion of carbohydrate (7.73%) is present, followed by protein (3.15%), fat (0.05%), and estimated total calories (43.97 kcal/g). Besides that, the number of micronutrients and minerals, viz., Na (26.08%), Mg (0.94%), Al (1.92%), P (1.21%), K (2.99%), and Ca (4.34%), was also estimated. These findings suggested that Batema could be a resource for dietary supplements, which improve the healthfulness of novel foods for human consumption. Unfortunately, this food product is sold locally, which on the contrary, can be revolutionized from its traditional production into large-scale production at the commercial level. Such an approach will help secure livelihoods and increase the production and trade of this unique product.

Digital forensics challenges and readiness for 6G Internet of Things (IoT) networks

AbstractThe development of sixth‐generation (6G) wireless communication technology is expected to provide super high‐speed data transmission, and advanced network performance than the current fifth‐generation (5G) and be fully functional by the 2030s. This development will have a significant impact and add improvements to digital extended reality (XR), autonomous systems, vehicular ad hoc networks (VANETs), artificial intelligence (AI), underwater communications, blockchain technology, pervasive biomedical informatics and smart cities built on the digital infrastructure backbone of the Internet of Things (IoT). The ubiquitous nature of this large‐scale 6G‐enabled IoT that offers faster connectivity capabilities and integrates both terrestrial and non‐terrestrial networks will not only create new data security and privacy issues but also provide a treasure trove of digital evidence useful for digital forensic examiners investigating security incidents and cybercrime. However, for digital forensic examiners, evidence collection, preservation and analysis will become a priority in the successful deployment of 6G IoT networks. In this study, we define key applications of 6G network technology to the Internet of Things and its existing architectures. The survey introduces potential digital forensic challenges and related issues affecting digital forensic investigations specific to 6G IoT networks. Finally, we highlight and discuss forensic readiness and future research directions for identified challenges within the 6G IoT network environments.This article is categorized under: Digital and Multimedia Science > IoT Forensics

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management.

Obesity affects more than 10% of the adult population globally. Despite the introduction of diverse medications aimed at combating fat accumulation and obesity, a significant number of these pharmaceutical interventions are linked to substantial occurrences of severe adverse events, occasionally leading to their withdrawal from the market. Natural products serve as attractive sources for anti-obesity agents as many of them can alter the host metabolic processes and maintain glucose homeostasis via metabolic and thermogenic stimulation, appetite regulation, pancreatic lipase and amylase inhibition, insulin sensitivity enhancing, adipogenesis inhibition and adipocyte apoptosis induction. In this review, we shed light on the biological processes that control energy balance and thermogenesis as well as metabolic pathways in white adipose tissue browning, we also highlight the anti-obesity potential of natural products with their mechanism of action. Based on previous findings, the crucial proteins and molecular pathways involved in adipose tissue browning and lipolysis induction are uncoupling protein-1, PR domain containing 16, and peroxisome proliferator-activated receptor-γ in addition to Sirtuin-1 and AMP-activated protein kinase pathway. Given that some phytochemicals can also lower proinflammatory substances like TNF-α, IL-6, and IL-1 secreted from adipose tissue and change the production of adipokines like leptin and adiponectin, which are important regulators of body weight, natural products represent a treasure trove for anti-obesity agents. In conclusion, conducting comprehensive research on natural products holds the potential to accelerate the development of an improved obesity management strategy characterized by heightened efficacy and reduced incidence of side effects.

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression.

Myxobacteria serve as a treasure trove of secondary metabolites. During our ongoing search for bioactive natural products, a novel subclass of disorazoles termed disorazole Z was discovered. Ten disorazole Z family members were purified from a large-scale fermentation of the myxobacterium Sorangium cellulosum So ce1875 and characterized by electrospray ionization-high-resolution mass spectrometry (ESI-HRMS), X-ray, nuclear magnetic resonance (NMR), and Mosher ester analysis. Disorazole Z compounds are characterized by the lack of one polyketide extension cycle, resulting in a shortened monomer in comparison to disorazole A, which finally forms a dimer in the bis-lactone core structure. In addition, an unprecedented modification of a geminal dimethyl group takes place to form a carboxylic acid methyl ester. The main component disorazole Z1 shows comparable activity in effectively killing cancer cells to disorazole A1 via binding to tubulin, which we show induces microtubule depolymerization, endoplasmic reticulum delocalization, and eventually apoptosis. The disorazole Z biosynthetic gene cluster (BGC) was identified and characterized from the alternative producer S. cellulosum So ce427 and compared to the known disorazole A BGC, followed by heterologous expression in the host Myxococcus xanthus DK1622. Pathway engineering by promoter substitution and gene deletion paves the way for detailed biosynthesis studies and efficient heterologous production of disorazole Z congeners. IMPORTANCE Microbial secondary metabolites are a prolific reservoir for the discovery of bioactive compounds, which prove to be privileged scaffolds for the development of new drugs such as antibacterial and small-molecule anticancer drugs. Consequently, the continuous discovery of novel bioactive natural products is of great importance for pharmaceutical research. Myxobacteria, especially Sorangium spp., which are known for their large genomes with yet-underexploited biosynthetic potential, are proficient producers of such secondary metabolites. From the fermentation broth of Sorangium cellulosum strain So ce1875, we isolated and characterized a family of natural products named disorazole Z, which showed potent anticancer activity. Further, we report on the biosynthesis and heterologous production of disorazole Z. These results can be stepping stones toward pharmaceutical development of the disorazole family of anticancer natural products for (pre)clinical studies.

Amphibian-derived wound healing peptides: chemical molecular treasure trove for skin wound treatment.

Amphibian-derived wound healing peptides thus offer new intervention measures and strategies for skin wound tissue regeneration. As novel drug lead molecules, wound healing peptides can help analyze new mechanisms and discover new drug targets. Previous studies have identified various novel wound healing peptides and analyzed novel mechanisms in wound healing, especially competing endogenous RNAs (ceRNAs) (e.g., inhibition of miR-663a promotes skin repair). In this paper, we review amphibian-derived wound healing peptides, including the acquisition, identification, and activity of peptides, a combination of peptides with other materials, and the analysis of underlying mechanisms, to better understand the characteristics of wound healing peptides and to provide a molecular template for the development of new wound repair drugs.

Archetypal Analysis of H. C. Andersen’s The Ugly Duckling: Turning a Loser into a Winner

The current article is devoted to the study of H. C. Andersen’s fairy tale The Ugly Duckling. The main subject of the study is the fabulous transformation of the tale’s protagonist from a loser into a winner. The research was performed within the archetypal paradigm originated by C. G. Jung (1875–1961). A simplified content analysis of the text was carried out using a set of archetypes composed of elements from the collections of С. Pearson and С. Myss. The study managed to a) identify the archetypal picture that accompanied the protagonist’s sad journey, b) find the key archetypes responsible for his unrelenting motivation to survive and search for a better life, and c) identify the archetypal mechanism of the hero’s transformation from a loser and an outcast into a winner. The results obtained allow us to conclude that Andersen’s fairy tale The Ugly Duckling is valuable from a scientific point of view as a treasure trove of human knowledge and historical experience. This fairy tale has great potential when applied to psychotherapy of trauma and to education, concretely, for work with children who have special needs. Great prospects for its use open up in the workplace, including management and the role training of manufacturers. In our rapidly developing information society, it seems that demand for this fairy tale will only grow.

Shaw Disarms the Man: War, Colonialism, and Theater in the 1890s (Arms and the Man, The Devil’s Disciple, and Caesar and Cleopatra)

Shaw Disarms the Man: War, Colonialism, and Theater in the 1890s (Arms and the Man, The Devil’s Disciple, <i>and</i> Caesar and Cleopatra)

Synthesis, in-silico design and spectral characterization, elucidation of Cannabis sativa L. cannabaceae containing phytoconstitutents demonstrating novel therapeutic efficacy against epilepsy

Cannabis sativa L. is a significant herbaceous species native to Central Asia that has been utilised for folk medicine and other industrial applications. It is a rich source of cellulosic and woody fibres as well as a treasure trove of phytochemicals. The pharmaceutical and construction industries are both very interested in this plant since its metabolites have powerful bioactivities on humans. Cannabinoids are the most researched class of chemicals, primarily because of the vast range of pharmacological effects they have on humans, including psychoactive effects. The phytoconstituents Apigenin and Alpha-bisabolol were synthesised in the current study, and Cannabis sativa L. phytoconstituent was further studied through in silico screening utilising (PDB ID: 6FYZ) along with spectral characterization NMR (1H and 13C) to confirm the presence of saturated and unsaturated moiety in Cannabis sativa L. phytoconstituents. Apigenin and Alpha-bisabolol, two phytoconstituents found in leaves and flower of Cannabis sativa L., were found to have higher docking scores and glide energies when comapred with the standard drugs like Levetiracetam. Cannabis sativa's phytoconstituent has been shown in in-silico studies to have high anti-epileptic potency, making it a crucial source for novel anti-epileptic/anti-convulsant/anti-seizure medications that in the future will focus on a variety of neurological diseaeses and disorders.

Bioactivity of Microbacterium barkeri (LMA4) In Vitro and Candidate Gene Annotation In Silico.

Actinomycetes are considered a never-ending treasure trove of biometabolites, which always fascinated researchers. However, to combat with newly emerging bacterial strains, the search for novel or analogs of existing therapeutic agents is recommended. In this context, this research work was carried out to search for a biopotent Actinomycetal strain grown in untapped soil, near the Hirakud dam. This Gram-positive bacteria was subjected to screening for its bioactivity against the medically important bacteria, isolated from local hospital sample using "co-culture" method, following both qualitative and quantitative assays. Further, the 16s rRNA sequencing, BLASTn analysis, and GC% calculation were carried out. Based upon its bioactivity, a prediction-based genomics work was pursued, considering the gene sequence deposited in public domain. The reverse translation, elution of protein structural file, and the putative protein were predicted. The strain was identified as Microbacterium barkeri, with 54.1% GC content. From Gene Ontology term annotation, it was predicted that the α/β hydrolase fold of hydrolase protein could have been responsible for antibiotic/biometabolite synthesis, in silico. The in vitro-based sequence (from Whole Genome Sequence data) had inferred that there was elution of alpha/beta hydrolase fold, substantiated with conserved domain analysis, ORF finding more over Gene Ontology (GO) terminology annotations. The GO annotations had suggested that the protein had been produced in response to a bacteria, under the influence of external stimuli more so in stress.

Theonella: A Treasure Trove of Structurally Unique and Biologically Active Sterols.

The marine environment is considered a vast source in the discovery of structurally unique bioactive secondary metabolites. Among marine invertebrates, the sponge Theonella spp. represents an arsenal of novel compounds ranging from peptides, alkaloids, terpenes, macrolides, and sterols. In this review, we summarize the recent reports on sterols isolated from this amazing sponge, describing their structural features and peculiar biological activities. We also discuss the total syntheses of solomonsterols A and B and the medicinal chemistry modifications on theonellasterol and conicasterol, focusing on the effect of chemical transformations on the biological activity of this class of metabolites. The promising compounds identified from Theonella spp. possess pronounced biological activity on nuclear receptors or cytotoxicity and result in promising candidates for extended preclinical evaluations. The identification of naturally occurring and semisynthetic marine bioactive sterols reaffirms the utility of examining natural product libraries for the discovery of new therapeutical approach to human diseases.

Impact of Artificial Intelligence Regulations on Organizational Risks

The data science industry has grown exponentially due to the surge in consumer consumption of technology-related services and products. Following closely is the data science specialty of Artificial Intelligence (AI) algorithm development and use, which holds significant potential for an organization’s bottom line. By combining these new AI capabilities with the treasure troves of new and legacy consumer data, organizations can automate decision-making to entice new consumers to their products and services. These AI capabilities come with a plethora of potential uses and misuses. Organizations must take stock of the precedence of laws and regulations related to consumer privacy and ensure careful consideration of AI risk management to balance the potential financial implications of AI algorithm development and use, good and bad.

Networking Operatic Italy Francesca Vella

Enrico Petrella’s funeral march in Jone (1858) might at first seem indistinguishable from other nineteenth-century musical ephemera. Performed by an on-stage banda in Act IV of the once widely performed opera, the ‘lugubrious’ march—as it was named in the autograph score—accompanies the dramatic walk of a wrongly accused lover to his execution. However, the performance history of the march on opera stages—and Jone toured the world extensively in its first decades of performances—would fail to hear its growing presence on Italian city streets. Shortly after the opera’s La Scala premiere, the signature march became a standard in Italian wind-band repertory, where it found new life (and death) in secular funerals across the peninsula and during Holy Week processions in parts of southern Italy. The march grew to function in the Italian cultural consciousness as ‘an inward cipher of death and mourning’ (p. 67). Stories like this, which unspool how an operatic artefact became entangled in Italian culture, pepper Francesca Vella’s recent book, Networking Operatic Italy. In this enticing monograph, artists and operas travel the globe, technologies evolve and malfunction, and literary, archival, and musical sources are put in dialogue in innovative ways. One of the book’s core arguments is that ‘opera has always had a special networking capacity’ (p. 14) Vella ‘networks’—and use of the verb is deliberate—nineteenth-century Italian opera with its supporting media, wider infrastructure of mobility, and surrounding cultural discourses. Her concept of the network is, in part, indebted to Bruno Latour’s actor-network theory and Bill Brown’s thing theory, as the objects central to her narrative are not passive components of opera’s history. Instead, objects, technologies, and ideas shape and condition opera through their affordances or limitations. Across five case studies of interconnected webs of people, ideas, and—of course—operas, Vella addresses transportation and communications media (railroads, wind-bands, voices, newspapers, and the telegraph) in the increasingly mobilized environment of Risorgimento and Liberal-era Italy. Her study of Italian opera journeys to various theatres across Italy, and the reader encounters works by Meyerbeer, Wagner, and Verdi, as well as those of the lesser-known Petrella. The five chapters examine scores of operatic works—most chapters contain hermeneutic readings of specific scenes—and intersect with the many participants and components of opera productions, as uncovered through painstaking archival efforts (the forty pages of endnotes are a treasure trove for any reader).

Regional Sustainable Strategy Based on the Coordination of Ecological Security and Economic Development in Yunnan Province, China

Coordination between ecological security and economic development is crucial to sustainable development, with a development strategy that should be adjusted according to the type of region. Yunnan Province, China, is a treasure trove of biodiversity but is economically lagging. Clarifying the relationship between ecological security and economic development can provide a reference for the sustainable development of similar biodiversity hotspots in the world. The landscape index method and index evaluation method were used to calculate the ecological safety index (ESI) and the economic development index (EDI), respectively, and the median value of the indices was used for the comprehensive zoning. The coupled coordination degree model (CCDM) was used to assess the coordination status of ecological safety and economic development in each zone. The results show that (1) Yunnan’s ecological security pattern is high in the west and low in the east, mainly influenced by topography, climate, and human activities; its economic development is resource-dependent and shows a multi-point dispersed pattern due to poor transportation; (2) Yunnan was partitioned into the Coordinated Development Zone (CDZ), the Ecological Risk Zone (ERZ), the Economic Poverty Zone (EPZ), and the Dual Pressure Zone (DPZ). Among them, CDZs (15%) are mostly areas with outstanding advantageous resources, mature characteristic industries, and relatively spatially dispersed. There are two types of ERZs (35%): one is an area where the intensity of human activities exceeds the ecological carrying capacity, mainly located in the eastern plateau; the other is an area with fragile ecological background conditions, located in high mountains and river valleys. EPZs (35%) are mainly lagging in socioeconomics of DPZ (15%) and the fragile ecological environment constrains each to form a negative cycle. (3) Of the regional coordination levels in Yunnan Province, 76% are moderately coordinated, and there is still space for development from the high-quality coordination level. The order of the average coordination degree of each partition is CDZ &gt; ERZ &gt; EPZ &gt; DPZ. The poor basis for coordination and the single approach to coordination have led to ecological safety and economic development often being more difficult to achieve in areas with large mountainous areas similar to Yunnan. (4) Due to the necessity for biodiversity protection, Yunnan Province should choose the sustainable path of ecological priority and green development. Specifically, CDZ should play to industrial advantages and brand effects, and promote industrial integration and innovative industrial development paths. The keys to ERZ are industrial restructuring, industrial ecologization, and ecological environment restoration and protection. EPZ should improve transportation and other infrastructure and revitalize economic development under the premise of ecological priority. Finally, DPZ should emphasize human and load reduction, and moderate development.

New Resources for California Scholars

Research Article| May 01 2023 New Resources for California Scholars: The American National Red Cross Historical Nurse Files, ca. 1916 to ca. 1959 Diane M. T. North Diane M. T. North DIANE M. T. NORTH is a retired History professor, University of Maryland Global Campus, from whom she received the 2018 Stanley J. Drazek Teaching Excellence Award. She is the author of California at War: The State and the People during World War I (Lawrence: University Press of Kansas, 2019). North, a member of the journal's Editorial Board, received the Western Association of Women Historians' Ridge Prize for the best scholarly article published in 2020: “California and the 1918-1920 Influenza Pandemic,” California History, Vol. 97, no. 3 (Fall 2020): 3-36. Search for other works by this author on: This Site PubMed Google Scholar California History (2023) 100 (2): 82–84. https://doi.org/10.1525/ch.2023.100.2.82 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Diane M. T. North; New Resources for California Scholars: The American National Red Cross Historical Nurse Files, ca. 1916 to ca. 1959. California History 1 May 2023; 100 (2): 82–84. doi: https://doi.org/10.1525/ch.2023.100.2.82 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCalifornia History Search On November 21, 2022, the U.S. National Archives and Records Administration (NARA) launched the redesign of its online catalog.1 One of the resources helpful for California scholars is “The American National Red Cross Historical Nurse Files, ca. 1916–ca. 1959,” a portion of the collection of the records of the American National Red Cross, 1881–2008 (ARC). These archives offer a treasure trove of information about the dedicated nurses who tended to the sick, wounded, and dying during World War I and World War II and their subsequent relationship with the ARC. The material includes correspondence, applications, biographical questionnaires, letters of reference, assignments, military orders, efficiency reports, memoranda, press clippings, and photographs.2 For example, the National Archives digitized seventy-two images of the records for Stockton native Elizabeth Haywood Ashe, who served as a chief nurse for the ARC’s Children’s Bureau in France during World War I (Figures 1 and... You do not currently have access to this content.

Fernando Pessoa: The Poet as Philosopher

AbstractFernando Pessoa (1888–1935) lived what was in many ways an astonishingly modern, transcultural, and translingual life. He was born in Lisbon, the point of departure for Vasco da Gama's voyage to India as commemorated by Pessoa's forebear, the poet Luís de Camões. Pessoa grew up in Anglophone Durban, acquiring a lifelong love for English poetry and language. Returning to Lisbon, from where he would never again leave, he set himself the goal of travelling throughout an infinitude of inner landscapes, to be an explorer of inner worlds. He published very little, but left behind a famous trunk containing a treasure trove of scraps, on which were written some of the greatest literary works of the twentieth century, mainly in Portuguese but also a substantial amount in English and French. Pessoa is now acknowledged as one of the greatest poets of the twentieth century, and he has emerged over the last decade as a forgotten voice in twentieth-century modernism, taking his rightful place alongside C.P. Cavafy, Franz Kafka, T.S. Eliot, James Joyce, and Jorge Luis Borges. Pessoa was also a serious student of philosophy and himself a very creative philosopher, yet his genius as a philosopher has as yet hardly been recognized at all.

Nypa fruticans endophytic fungus Cichorin A displays a weak cytotoxic activity against mouse lymphoma

A keen interest and attention have been given to studies on Endophytic fungus as a substitute or an alternative to the traditional source of drugs which is principally plant as a result of its interesting bioactive products. This may be an additional means of increasing the yields of those already obtained from plants or a source of entirely new ones. In essence, it is a treasure trove of therapeutically active metabolites. The aim of the study was to challenge Cichorin A isolated from Pestalotiopsis sp. against mouse lymphoma cell line. The result showed that it has a weak activity with a growth inhibitory effect of 31.2%

Marine Aspergillus: A Treasure Trove of Antimicrobial Compounds.

Secondary metabolites from marine organisms are diverse in structure and function. Marine Aspergillus is an important source of bioactive natural products. We reviewed the structures and antimicrobial activities of compounds isolated from different marine Aspergillus over the past two years (January 2021-March 2023). Ninety-eight compounds derived from Aspergillus species were described. The chemical diversity and antimicrobial activities of these metabolites will provide a large number of promising lead compounds for the development of antimicrobial agents.

Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques.

Cancer is a primary global health concern, and researchers seek innovative approaches to combat the disease. Clinical bioinformatics and high-throughput proteomics technologies provide powerful tools to explore cancer biology. Medicinal plants are considered effective therapeutic agents, and computer-aided drug design (CAAD) is used to identify novel drug candidates from plant extracts. The tumour suppressor protein TP53 is an attractive target for drug development, given its crucial role in cancer pathogenesis. This study used a dried extract of Amomum subulatum seeds to identify phytocompounds targeting TP53 in cancer. We apply qualitative tests to determine its phytochemicals (Alkaloid, Tannin, Saponin, Phlobatinin, and Cardic glycoside), and found that alkaloid composed of 9.4% ± 0.04% and Saponin 1.9% ± 0.05% crude chemical constituent. In the results of DPPH Analysis Amomum subulatum Seeds founded antioxidant activity, and then we verified via observing methanol extract (79.82%), BHT (81.73%), and n-hexane extract (51.31%) found to be positive. For Inhibition of oxidation, we observe BHT is 90.25%, and Methanol (83.42%) has the most significant proportion of linoleic acid oxidation suppression. We used diverse bioinformatics approaches to evaluate the effect of A. subulatum seeds and their natural components on TP53. Compound-1 had the best pharmacophore match value (53.92), with others ranging from 50.75 to 53.92. Our docking result shows the top three natural compounds had the highest binding energies (-11.10 to -10.3kcal/mol). The highest binding energies (-10.9 to -9.2kcal/mol) compound bonded to significant sections in the target protein's active domains with TP53. Based on virtual screening, we select top phytocompounds for targets which highly fit based on pharmacophore score and observe these compounds exhibited potent antioxidant activity and inhibited cancer cell inflammation in the TP53 pathway. Molecular Dynamics (MD) simulations indicated that the ligand was bound to the protein with some significant conformational changes in the protein structure. This study provides novel insights into the development of innovative drugs for the treatment of cancer disorders.