Treasure Trove Research Articles

Drug-likeness analysis, in silico ADMET profiling of compounds in Kedrostis foetidissima (Jacq.) Cogn, and antibacterial activity of the plant extract.

Plants are a treasure trove of bioactive compounds. Kedrostis foetidissima (Jacq.) Cogn. has many important phytoconstituents like cucurbitacins, rutin, and quercitin compounds. Among these compounds, Quercetin-3-O- Rhamnoside (1) has antioxidant, anti-inflammatory, anticancer properties. Rutin (2) has anti-inflammatory, antioxidant, anti-diabetic, anti-microbial, antiviral properties, 7, 10-Hexa decadienoic acid methyl ester (3) has anti-inflammatory, antioxidant, hypocholesterolemia and anticancer activities. Docosanoic acid (4) has antioxidant, α-Glucosidase inhibitory activity. 3,7,11,15-Tetra methyl hexa decan-1-ol (5) has antiviral properties. Cucurbitacin-B (6) has antipyretic, analgesic, anti-inflammatory, antimicrobial, and antitumor activities. Performance of experimental studies on phytochemicals become more difficult as the availability of compounds in small quantities, hence the computational methods becomes important for drug discovery. Based on their biological activity, compounds 1-6 were tested for in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiling and drug-likeness properties using the Swiss ADME online web server and the pkCSM server. All the studied compounds obey Lipinski's rule of five except compounds 1 and 2 with two and three violations each. The entire selected compounds have a good bioavailability score in the recommended range of 0 to 1. Compound 4 has high (0.85) and compounds 1 and2 have low (0.17) oral bioavailability scores. All the selected compounds from Kedrostis foetidissima have strong pharmacological activities. Supporting this, the selected plant methanol extracts of leaf, stem callus, and tuber have shown well in vitro antibacterial activity against Bacillus subtilis, Escherichia coli, and Proteus vulgaris. Therefore, these compounds may be developed into drug molecules with additional clinical research.

Corpus-based Translation Studies: Examining Media Language through a Linguistic Lens

This paper delves into the multifaceted world where translation studies converge with corpus linguistics, casting a spotlight on the dynamic domain of media language. By harnessing the power of a corpus-based methodology, our research meticulously dissects the intricate process of translating and adapting media texts within a panoply of linguistic landscapes and cultural contexts. The core objective of the study is to excavate and analyze the pantheon of linguistic attributes and the repertoire of tactics translators wield in the realm of media, unlocking a treasure trove of understanding pertaining to cultural subtleties and the nuanced art of translation practices. Our exploration traverses a broad spectrum of media genres, encompassing the rigor of news journalism, the creative complexity of television programming, and the viral nature of digital content, to construct a comprehensive understanding of the translation phenomena at play. The findings illuminate the myriad ways in which media narratives are reconfigured and presented to global audiences, ultimately enriching the discourse on how translation shapes and is shaped by the currents of worldwide communication. This study, therefore, serves as a crucial beacon for academics, professionals, and enthusiasts poised at the crossroads of linguistics and cultural exchange, guiding them through the labyrinth of media translation and its profound influence on international dialogues and perceptions.

NORMALIZATION OF ONLINE SHOP PAYMENTS THROUGH THE SHOPEEPAY LATER SERVICE QS PRESPECTIVE ALI IMRAN Verse 130

Abstract
 This study aims to discuss the law of the shopeepay later feature in the Qs perspective shopee application. Ali Imran verse 130 because many people are currently normalizing the shopeepay later service for the payment system at shopee. This study uses a qualitative approach research method using maudhu'i interpretation. Maudhu'i interpretation is a method of interpretation that seeks to find answers to the Qur'an by collecting verses of the Qur'an that have one goal. The results of the discussion of this study indicate that the use of the shopeepay later service contains an element of usury Qard, this occurs because the Shopee Paylater element provides personal benefits for Shopee alone. The public currently has an obligation to avoid using the shopeepay later payment feature in the shopee application. This research is expected to provide benefits as a treasure trove of knowledge about the shopeepaylater feature in a QS perspective. Ali Imran verse 130 so that people at this time can minimize or even avoid using shopeepay later. This research has limitations because it only discusses from one interpreter's point of view and only discusses Qs. Ali Imran verse 130. This study recommends further research with different methods so that the results are more recent, and valid.
 Keywords: Al-Qur'an, Shopee, Shopeepay later

Travelogs of Journeys to Lithuania in Early 15th–19th Century: The Problem of Egodocumentality and Typology

The article discusses the egodocumentary travel writing of trips to/inside Lithuania, which is characterised by an autobiographical first-person narration, and examines its origins, development, and dissemination. Based on the methodological paradigms of research into the cultural heritage of a manuscript and printed book, the concepts of memory archive, book communication cycle, and the social life of books, an attempt is made to draw the boundaries among the types of this writing (typology), and the intentions of the writing and publishing process are revealed. The case study is based on manuscript and published travel descriptions by both Lithuanian and foreign authors for the routes in the territory of Lithuania or on the Lithuanian border. It was found that first-person narration and an author’s ‘participation’ are present not only in manuscript travel accounts that are personal and those belonging to one’s relatives (family, clan, descendants), but also in texts that engage a wider audience and are published and distributed through various media. The attempt at a typology of travel egodocumentation revealed a gap between a genetic taxonomy based on the notion of the personal archive as a treasure trove of memory and a literary classification based on contemporary genres of travel writing. Travel accounts were created on the basis of the worldview prevailing in the society of the Grand Duchy of Lithuania, which formed a canon different from the European one. Noteworthy are the hitherto understudied egodocumentary marginalia, diaries in calendars that reflect the culture of travel in the Grand Duchy of Lithuania.

Preface

The Palaeogene Skaergaard intrusion, East Greenland, has since its first description by Wager & Deer (1939) been a foremost natural laboratory for the study of low-pressure fractionation of basaltic melt. Ocean floors are composed of basalt and the processes that control compositions of basaltic melts are fundamental to the dynamics of the Earth. This special issue of GEUS Bulletin by Peter Thy, Christian Tegner and Charles E. Lesher is the most recent in a more than eighty year succession of trendsetting works on the evolution of the Skaergaard intrusion and evolution of basaltic melt. The early sample collections, housed in the universities of Oxford and Cambridge, were used for the development of fractionation models, mapping of the distribution as well as the partition of major and trace elements between melts and liquidus phases in basaltic melts. These and many other studies resulted in the monumental “Layered Igneous Rocks”, edited by L.R. Wager and G.M. Brown (Wager & Brown 1968). By the 1970s, the original collection in the Oxford University Museum of Natural History and the Sedgwick Museum of Earth Sciences, University of Cambridge had seen extensive use. The science developed and new and more detailed sampling was now required. Fieldwork and sampling in the later part of the 20th century led to a flurry of new studies by more research groups, including Neil Irvine of Carnegie’s Geophysical Laboratory and the University of Oregon group lead by Alex McBirney. Despite all the efforts, no consensus was reached on the many fundamental chemical and physical processes in basaltic magma chambers. The available collections did not provide sufficiently systematic and detailed information for the modelling of the evolution of the basaltic melt and the genesis of the precious metal deposit that had been discovered in the intrusion. Exploration drill cores offered the possibility for tight stratigraphic sampling through >1000 m of gabbro. In combination with surface sampling, a new standard profile with superior systematics could be established. In the summer of 2000, the Danish Lithosphere Centre (DLC) organised fieldwork and the transport of the drill cores to the Museum of Natural History in Copenhagen. This special issue is part of the legacy of the DLC and a fulfilment of the then envisaged potential of the Skaergaard intrusion for fundamental studies of processes in basaltic magma chambers. Thy et al. (2023, this volume) analyse and compile in unprecedented detail the variation in major and trace element compositions of bulk-rock samples and electron microprobe compositions of rock-forming minerals in the Layered Series on the floor of the intrusion. In addition, they include a wealth of information on all samples from the Skaergaard intrusion that are housed in museum, university and survey collections in Denmark, the UK and US, topographic and geological maps, aerial photographs in archives and images of thin sections used in the study. With all its data and appendices, the monograph is the most comprehensive collection of petrological information for the Skaergaard intrusion and the Layered Series on the floor of the intrusion, ever to have been made available for research. The detailed modelling presented re-evaluates petrogenetic constraints and tests petrogenetic models in the literature. The modelling is based on liquidus proportions established in experimental studies of appropriate melt compositions. Thy and co-authors conclude that evolution observed in the gabbros of the Layered Series is predominantly controlled by crystal fractionation of bulk liquid. Late in the evolution and above the boundary between Upper Zone a and b, the gabbros crystallised from ponded Fe-rich, immiscible melt. Redistribution of granophyric melts and decoupling of included and excluded trace elements, not only in bulk liquid but also in mush melts, complicates the modelling of trace element distributions in the late and evolved stages of crystallisation in the crystal mushes of the intrusion. This special issue is a treasure trove for all who study the intrusion and are searching for a data set to be matched with experimental and numeric modelling of low-pressure fractionation of basaltic melt. With this contribution, the Skaergaard intrusion continues to be a foremost natural laboratory for modelling of melts formed in solidifying basaltic magma chambers. Troels F.D. NielsenEmeritus, GEUS, Denmark

Using learners’ problem-solving processes in computer-based assessments for enhanced learner modeling: A deep learning approach

Successful computer-based assessments for learning greatly rely on an effective learner modeling approach to analyze learner data and evaluate learner behaviors. In addition to explicit learning performance (i.e., product data), the process data logged by computer-based assessments provide a treasure trove of information about how learners solve assessment questions. Unfortunately, how to make the best use of both product and process data to sequentially model learning behaviors is still under investigation. This study proposes a novel deep learning-based approach for enhanced learner modeling that can sequentially predict learners’ future learning performance (i.e., item responses) based on modeling their history learning behaviors. The evaluation results show that the proposed model outperforms another popular deep learning-based learner model, and process data learning of the model contributes to improved prediction performance. In addition, the model can be used to discover the mapping of items to skills from scratch without prior expert knowledge. Our study showcases how product and process data can be modelled under the same framework for enhanced learner modeling. It offers a novel approach for learning evaluation in the context of computer-based assessments.

Digital Humanities as a Treasure Trove for the Developing Countries: An Exploration

Digital humanities integrate the methods from conventional humanities disciplines (such as rhetoric, history, philosophy, linguistics, literature, art, archaeology, music, and cultural studies) and social sciences. It encompasses both digitized and born-digital materials. In addition to altering our way of life, contemporary technology has also had an impact on our perceptions, thoughts, and analyses of modernity. An Integrated Learning Major (ILM) called “digital humanities” blends the conventional humanities strengths with an emphasis on digital and information technology. As a tool for the humanities and as a subject of humanistic study, it allows students to expand their knowledge of the humanities to digital culture. Communication between people is always the foundation of social behavior. Communication tools, access is now incredibly simple and reasonably priced. In the subject of literature, organizing the deluge of information properly is a major difficulty. Not only has modern technology altered our way of life, but it has also had an impact on our perception, reasoning, and analysis. This article reveals that Digital humanities as a treasure trove for the developing countries through literature, language and other areas such as the arts (e.g. paintings, sculpture, architecture, music, films), philosophy, psychology and social sciences (e.g. politics, economics, history,sociology).

Millets - Neglected Cereal with High Potential in Health Benefits in Malnutrition

In a world grappling with malnutrition, millets emerge as unsung heroes, offering a beacon of hope for improved global health. This chapter delves into the treasure trove of millets, revealing their often-overlooked potential as a nutritional powerhouse. Millets, a diverse group of cereal grains, hold the promise of mitigating malnutrition on a global scale. Firstly, we explore the exceptional nutritional value of millets, demonstrating how they pack a punch with essential vitamins, minerals, and dietary fiber. A comparative analysis with other grains underscores their superiority in providing a balanced diet. We then uncover the diverse varieties of millets and their suitability for various regions and climates, making them an adaptable and sustainable choice for farmers worldwide. Millet farming techniques, including their resilience to adverse conditions, are discussed, shedding light on their role in food security.
 The health implications of millet consumption are another focus, revealing their potential in preventing chronic diseases and improving overall well-being. Case studies underscore the tangible impact of millet-based interventions on malnutrition reduction. However, challenges persist, such as limited awareness and policy support. Nonetheless, millets hold immense promise for enhancing global health and nutrition. This chapter advocates for the integration of millets into our diets, promoting sustainable agriculture, and addressing malnutrition's root causes. As we delve into the world of millets, we find not only a neglected cereal but a beacon of hope for a healthier, more sustainable future.

Harnessing fungal endophytes for natural management: a biocontrol perspective.

In the ever-evolving realm of agriculture, the convoluted interaction between plants and microorganisms have assumed paramount significance. Fungal endophytes, once perceived as mere bystanders within plant tissues, have now emerged as dynamic defenders of plant health. This comprehensive review delves into the captivating world of fungal endophytes and their multifaceted biocontrol mechanisms. Exploring their unique ability to coexist with their plant hosts, fungal endophytes have unlocked a treasure trove of biological weaponry to fend off pathogens and enhance plant resilience. From the synthesis of bioactive secondary metabolites to intricate signaling pathways these silent allies are masters of biological warfare. The world of fungal endophytes is quite fascinating as they engage in a delicate dance with the plant immune system, orchestrating a symphony of defense that challenges traditional notions of plant-pathogen interactions. The journey through the various mechanisms employed by these enigmatic endophytes to combat diseases, will lead to revelational understanding of sustainable agriculture. The review delves into cutting-edge research and promising prospects, shedding light on how fungal endophytes hold the key to biocontrol and the reduction of chemical inputs in agriculture. Their ecological significance, potential for bioprospecting and avenues for future research are also explored. This exploration of the biocontrol mechanisms of fungal endophytes promise not only to enrich our comprehension of plant-microbe relationships but also, to shape the future of sustainable and ecofriendly agricultural practices. In this intricate web of life, fungal endophytes are indeed the unsung heroes, silently guarding our crops and illuminating a path towards a greener, healthier tomorrow.

Mapping Media Developments and Issues: Topics, Clusters, and Content ofJMCQArticles on Communication Technology/Media Channels, 1935–2017

This study analyzed JMCQ articles in the specific topic area of mass communication technology and media channels, overall and across four 20-year periods. Primary topics changed from emphasizing media industry and policy issues, international issues of information freedom, audience research, and WWII media issues in early periods to more specific regulatory issues, ratings and audience analyses, macro and social issues, and media technology development issues in more recent periods. JMCQ serves as a treasure trove of the history of broadcast media technology and competition, policy debates, and audience interests, with a recent emphasis on more rigorous empirical analyses.

A curious account of ancient Egyptian Treasure Trove in Scotland

An ancient Egyptian object buried in the grounds of a historic house near Monimail in Fife was found by chance in 1952 and acquired at the time by the then Royal Scottish Museum (now National Museums Scotland). A second object from the same location appeared by chance in 1966 and was shown to the Museum but not accessioned. The revelation of a third object in 1984 prompted an investigation that produced clear evidence there had once been a larger collection of Egyptian antiquities at Melville House. This paper offers the first published account of how these events unfolded and discusses the possible origins of the collection through a visit to Egypt by members of the Leslie-Melville family in 1856–7. The third object and the finds made in 1984 during the investigation were claimed by the Crown as Treasure Trove and all are now in the collections of National Museums Scotland. They are apparently the only ancient Egyptian items to have been declared as Treasure Trove in Scotland. A catalogue of these objects, along with the original find, is provided. The main text of the paper is by Elizabeth Goring with additional comments by Margaret Maitland; the catalogue is by Margaret Maitland.
 Canmore ID 30153

19. Yüzyılda Batılı Seyyahların Gözüyle Bursa Hisar Bölgesi

The territories once occupied by the Ottoman Empire, replete with cultural abundance, have perennially captivated the attention of explorers. Bursa stands as a quintessential city, epitomizing the cultural opulence of the Ottoman heritage. With this value, Bursa has attracted the attention of foreign travelers for centuriesand travelers have visited this city for various reasons. Visits began in the 15th century, increased in the 19th centuryand many diplomats, merchantsand scientists came to the city. Most of the travelers who came also explored and researched the Hisar District, the historical center of Bursa.
 When looking at the 19th century, it becomes evident that, just as in previous centuries, the Hisar District, in addition to the city's overall social life and cultural wealth, has garnered the interest of travelers. Within the societal urban structure of Hisar, historical edifices, its architectural fabric, monumental structures, the fort's layout, religious establishmentsand other social constructs have amplified this interest. For this reason, the district is deemed significant by these travelers. They have articulated their perspectives about the Hisar District in their travelogues. Furthermore, travelers have elaborated on the Hisar District's physical structures, its history, architectureand artistic attributes in their writings.

A Multi-Class Deep Learning Approach for Early Detection of Depressive and Anxiety Disorders Using Twitter Data

Social media occupies an important place in people’s daily lives where users share various contents and topics such as thoughts, experiences, events and feelings. The massive use of social media has led to the generation of huge volumes of data. These data constitute a treasure trove, allowing the extraction of high volumes of relevant information particularly by involving deep learning techniques. Based on this context, various research studies have been carried out with the aim of studying the detection of mental disorders, notably depression and anxiety, through the analysis of data extracted from the Twitter platform. However, although these studies were able to achieve very satisfactory results, they nevertheless relied mainly on binary classification models by treating each mental disorder separately. Indeed, it would be better if we managed to develop systems capable of dealing with several mental disorders at the same time. To address this point, we propose a well-defined methodology involving the use of deep learning to develop effective multi-class models for detecting both depression and anxiety disorders through the analysis of tweets. The idea consists in testing a large number of deep learning models ranging from simple to hybrid variants to examine their strengths and weaknesses. Moreover, we involve the grid search technique to help find suitable values for the learning rate hyper-parameter due to its importance in training models. Our work is validated through several experiments and comparisons by considering various datasets and other binary classification models. The aim is to show the effectiveness of both the assumptions used to collect the data and the use of multi-class models rather than binary class models. Overall, the results obtained are satisfactory and very competitive compared to related works.

The Death of Fanny Godwin in Helen Edmundson’s Mary Shelley

Fanny Godwin, as the daughter of renowned writer and activist Mary Wollstonecraft and stepdaughter of political philosopher William Godwin, has received relatively limited attention from literary scholars compared to the other eminent members of her family. Helen Edmundson’s 2012 play Mary Shelley acknowledges the impacts that Fanny would have had on her half-sister Mary while depicting Mary’s early life. This article is one of the first in-depth textual analyses of the play and examines Edmundson’s portrayal of Fanny in the Godwin household. In particular, the article investigates the extent to which Edmundson renders familial relationships as the root cause of Fanny’s suicide, scrutinising the relationships which Godwin and Mary have with Fanny alongside the influence of outside pressures. Drawing on psychoanalytic and family-systems psychotherapy approaches, the article contends that Edmundson places specific emphasis on dynamics within the Godwin family in contributing to Fanny’s death, arguably more so than the few literary biographies that have explored this tragedy. To enrich the discussion, the researcher conducted a personal interview with Helen Edmundson, facilitating a comparison between reader interpretations with the playwright’s intentions. Ultimately, this article contributes to a deeper understanding of the Godwin family and their profound impacts on Fanny’s life and death.

COMPREHENSIVE STUDY ON THE TOXICOLOGICAL EVALUATION OF AYURVEDIC MEDICATIONS: A CASE OF YASHADA BHASMA AND YASHADA PUSHPA BHASMA IN SWISS ALBINO MICE

Ayurveda, an ancient system of medicine rooted in India, offers a treasure trove of herbal and mineral formulations. Yashada Bhasma1 and Yashada Pushpa Bhasma are two formulations that have gained popularity for their potential therapeutic properties. Traditional Ayurvedic medicines, such as Yashada Bhasma, have been used for centuries to treat various ailments. However, with the surge of interest in Ayurvedic medicine, there is a growing need for rigorous scientific assessments to evaluate their safety and efficacy. This study assessed the subacute toxicity of traditional Ayurvedic medicines, Yashada Bhasma and Yashada Pushpa Bhasma, in Swiss albino mice. This paper presents the results of a comprehensive toxicological study conducted on Swiss albino mice to determine the safety profiles of Yashada Bhasma and Yashada Pushpa Bhasma. These findings underscore the importance of proper dosing and further research, facilitating the safe and effective use of these traditional Ayurvedic preparations in modern healthcare.

Unlocking Nature’s Treasure Trove: Exploring Microorganisms for Novel Bioactives

From the marine environment to plants and animals, microorganisms are everywhere. Microbes happen to be a very prominent resource of metabolites and bioactive compounds and in recent times, many therapeutic compounds have been discovered from microbial sources. This review provides an in-depth exploration into the world of microorganisms as a treasure trove of novel bioactives. Different groups of microbes contain unique metabolites and bioactive that might have the potential as therapeutic agents. So, it is very important to screen microbial metabolites to identify, isolate and characterize for potential therapeutic applications. Microbial metabolites are very advantageous in terms of large-scale production and purity of final products. Considering these advantages, research focusing on screening potential microbial bioactive is a very time demanding one. This comprehensive review aims to inspire researchers and stakeholders to further explore and unlock the vast potential of microorganisms for the discovery and development of innovative bioactive compounds.

The ART of RNAylation: covalent RNA–protein linkage in bacteriophage infection

Bacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA–protein linkages.

Outer Baduy as an Eco-Gastronomic Tourism Destination Area (Outer Baduy Eco-Gastronomic Study)

Gastronomic tourism, a multifaceted concept encapsulating one's holistic experience with food and beverages, is becoming increasingly significant in the realm of travel and cultural exploration. This research embarks on a compelling journey to unravel the potential for gastronomic tourism development within the enchanting landscapes of Outer Baduy. A descriptive qualitative approach intertwined with an ethnographic paradigm forms the foundation of this investigative endeavor. The methodology employed to gather insights is centered around in-depth interviews with an array of informants encountered during an immersive sojourn in Outer Baduy. Evidently, gastronomy in this region holds untapped promise, offering a treasure trove of opportunities for further exploration. The rich tapestry of community activities in Outer Baduy is poised to serve as captivating tourist attractions. These include active engagement in the traditional practices of planting huma rice, extracting palm sap to craft delectable palm sugar, and the thrill of foraging for honey in the lush forests. Furthermore, the preservation of age-old customs and rituals, such as the solemn observance of "ngaseuk" marking the commencement of huma rice cultivation, adds a profound layer to the gastronomic journey, showcasing the enduring tapestry of culture and tradition within Outer Baduy. The findings of this study suggest that gastronomic tourism in this unique region holds immense potential, offering an authentic and enriching experience for travelers seeking to explore the intersection of food, culture, and tradition.

The War Against White-Collar Crime: Elite Lawbreaking and the January 6th Attack on the U.S. Capitol

The Final Report of the Select House Committee to Investigate the Jan. 6th Attack on the United States Capitol released in late 2022, contains a treasure trove of facts indicating that former President Donald Trump and others around him allegedly engaged in a number of crimes related to the insurrection and attempted self-coup. The unprecedented assault on the Capitol, federal and state indictments, and ongoing investigations provide an opportunity to both examine elite criminality and evaluate government response through the lens of white-collar criminology. This essay considers: 1) how government criminality and corruption are facilitated by rationales and excuses that deny effective social condemnation; 2) their political weaponization; 3) how they constitute part of a larger existential war against white-collar crime that seeks to normalize such lawbreaking; and 4) the inherent difficulties in researching, controlling, and preventing elite crime more generally.

Organotypic heterogeneity in microvascular endothelial cell responses in sepsis-a molecular treasure trove and pharmacological Gordian knot.

In the last decades, it has become evident that endothelial cells (ECs) in the microvasculature play an important role in the pathophysiology of sepsis-associated multiple organ dysfunction syndrome (MODS). Studies on how ECs orchestrate leukocyte recruitment, control microvascular integrity and permeability, and regulate the haemostatic balance have provided a wealth of knowledge and potential molecular targets that could be considered for pharmacological intervention in sepsis. Yet, this information has not been translated into effective treatments. As MODS affects specific vascular beds, (organotypic) endothelial heterogeneity may be an important contributing factor to this lack of success. On the other hand, given the involvement of ECs in sepsis, this heterogeneity could also be leveraged for therapeutic gain to target specific sites of the vasculature given its full accessibility to drugs. In this review, we describe current knowledge that defines heterogeneity of organ-specific microvascular ECs at the molecular level and elaborate on studies that have reported EC responses across organ systems in sepsis patients and animal models of sepsis. We discuss hypothesis-driven, single-molecule studies that have formed the basis of our understanding of endothelial cell engagement in sepsis pathophysiology, and include recent studies employing high-throughput technologies. The latter deliver comprehensive data sets to describe molecular signatures for organotypic ECs that could lead to new hypotheses and form the foundation for rational pharmacological intervention and biomarker panel development. Particularly results from single cell RNA sequencing and spatial transcriptomics studies are eagerly awaited as they are expected to unveil the full spatiotemporal signature of EC responses to sepsis. With increasing awareness of the existence of distinct sepsis subphenotypes, and the need to develop new drug regimen and companion diagnostics, a better understanding of the molecular pathways exploited by ECs in sepsis pathophysiology will be a cornerstone to halt the detrimental processes that lead to MODS.