Barkam-Luqu-Gulang deep seismic sounding profile runs from north of Sichuan Province to south of Gansu Province. It is located at the northeastern edge of Tibetan Plateau and crosses eastern A’nyemaqen suture zone. The upper crust structures around eastern A’nyemaqen suture zone and its adjacent area are reconstructed based on the arrival times of refracted Pg and Sg waves by using finite difference method, ray tracing inversion, time-term method and travel-time curve analysis. The results show that the depth variation of basement along profile is very strong as indicated by Pg and Sg waves. The basement rose in Zoige basin and depressed in eastern A’nyemaqen suture zone, and it gradually rose again northward and then depressed. The results also indicate that eastern A’nyemaqen suture zone behaves as inhomogeneous low velocity structures in the upper crust and is inclined toward the south. Hoh Sai Hu-Maqen fault, Wudu-Diebu fault and Zhouqu-Liangdang fault are characterized by low velocity distributions with various scales. The distinct variation in basement depth occurred near Hoh Sai Hu-Maqen fault and Zhouqu-Liangdang fault, which are main tectonic boundaries of A’nyemaqen suture zone. Wudu-Diebu fault, located at the depth variation zone of the basement, possibly has the same deep tectonic background with Zhouqu-Liangdang fault. The strongly depressed basement characterized by low velocity distribution and lateral inhomogeneity in A’nyemaqen suture zone implies crushed zone features under pinching action.