Transverse Axis Research Articles

Electrically Injected Metamaterial Grating DFB Laser Exploiting an Ultra‐High Q Electromagnetic Induced Transparency Resonance for Spectral Selection

AbstractThe study shows that, in waveguide (WG) configuration, the coupling of a 2D plasmonic metamaterial grating (MMG) having a conventional Bragg period along the guide but a distinct period along the transverse axis can lead to Electromagnetically‐Induced‐Transparency (EIT) behavior. This epitomizes that metamaterials, as functional photonic building blocks, can lead to low losses in many standard devices if properly designed. The study reported the observation in passive WGs of a marked Fano‐type EIT resonance with record high‐quality factor: Q = 5000 and contrast >20 dB. Unlike any standard metal grating, MMG‐assisted waveguides exhibit strong grating coupling strength and low‐loss properties simultaneously. This concept is further applied to demonstrate single‐frequency‐emission electrically‐injected Distributed Feedback (DFB) lasers in the near‐infrared telecom domain. The key point is that laser emission occurs at the peak of EIT, i.e., the maximum in transmission. It therefore addresses one of the main critical issues of DFB lasers related to the single frequency yield. The laser performances are state‐of‐the‐art (Ith < 20 mA, Pmax > 20 mW at I = 200 mA, SMSR > 50 dB, optical feedback tolerance >−21 dB compliant with IEEE 802.3 standard). The presented approach, compatible with existing industrial technologies, is promising for real‐life telecom applications.

Influence of floor inclination on handle push and pull forces production of the upper limb

Floor inclination can alter hand force production, and lower limb kinetics, affecting control operations, and threatening operator safety in various domains, such as aviation, naval, construction industry, or agriculture. This study investigates the effects of different floor inclinations, on handle push or pull force production. Participants performed maximal isometric contraction tasks requiring to exert a maximal voluntary force either by pulling or pushing a handle, at different floor inclinations from −30° to +30° about the transverse and longitudinal axes. Maximal hand force and Ground Reaction Forces about both feet were recorded. The results revealed non-equivalent variations in hand and feet responses as a function of inclination angle. Specifically, there was a significant reduction in handle push-pull force production, up to 70% (p < 0.001) for extreme inclinations, around both axes. This study provides critical data for design engineers, highlighting the challenge of production forces at steep angles.

Water as A Transversal Axis of Learning in School Textbooks For Chilean Primary Education Students

Objective: The objective of this study is to investigate the presence of water as a transversal learning axis in the activities of Natural Science textbooks in Chilean Basic Education. Theoretical Framework: The theoretical framework is associated with the 2030 Agenda and the Sustainable Development Goals, the Chilean science curricular bases, as well as the didactic management associated with school textbooks. Method: The mixed method is followed, through content analysis, the elaboration of a priori categories, supported by quantitative elements to describe and interpret the data obtained from the analysis of school textbooks. Results and Discussion: The results obtained revealed the presence of activities, still insufficient, that deal with the topic of water in the texts. The highest frequencies of educational activities are found in the fifth and sixth grades. The skills promoted are intellectual capacities (operations to acquire, recover, solve problems and retain different types of knowledge); on the other hand, the skills that demand a process of practice (mastery of the technique or skill), attitudes and habits, such as ways of acting and behaving, are the least promoted. Research Implications: The implications of the study are referred to the methodology of science teaching in Basic Education and the respective teacher training. Originality/value: The results of the study contribute to filling a gap in the literature related to the teaching of water proposed in school textbooks. With this, guidelines are provided to improve the activities suggested in the textbooks, promoting awareness of water, its reuse and conservation.

ADIPOSE CELLULAR INJECTION IN THE TREATMENT OF AN INTRASUBSTANCE ACHILLES TENDON TEAR

Introduction: We describe a case report of a patient who presented with chronic right Achilles tendon pain and weakness. Without contrast, magnetic resonance imaging of the right Achilles tendon revealed significant expansion of the Achilles tendon in the traverse and anteroposterior dimension with extensive increased T2 signal consistent with large partial-thickness Achilles tendon tear. A musculoskeletal ultrasound using a linear transducer demonstrated an anechoic tendon defect measuring 0.97 cm in the longitudinal axis with a total tendon length measuring 1.53 cm, as well as a 0.9 cm defect in the transverse axis surrounded by homogenous tendon fibers consistent with a large defect involving the distal Achilles tendon proximal to the distal insertion. The patient underwent an ultrasound-guided adipose cellular procedure using micronized fat to fill in the defect and facilitate pain reduction and tissue healing.Conclusion: Ultrasound-guided injection of micro-fragmented adipose tissue of Achilles tendon defect can result in significant improvement in pain and function

Influential factors on the echogenicity of peripheral venous catheters: Insights from an experimental phantom study.

Ultrasound-guided placement of peripheral venous catheters requires appropriate equipment. Among the devices used, peripheral venous catheters have different structure and properties. This study aimed to define the impact of these different factors on the echogenicity of peripheral venous catheters. An open comparative study was conducted from September 2022 to May 2023. Thirteen devices were introduced in a standardized manner along the longitudinal and transverse axes with the help of guides into a phantom at different angles. Two criteria defined the echogenicity of these devices: the surface occupied by the device in the image (composite criterion: length and diameter of the device and angle of insertion) and its brightness (average of the pixel intensity of gray). Sixty-five ultrasound images were recorded and postprocessed twice (blinded to the previous measurement) by an expert operator, for reproducibility purposes. The intra-observer reproducibility of all measurements was excellent, with an intra-class coefficient of >0.90 over the entire dataset. On the longitudinal axis, echogenicity was significantly influenced by insertion angle (p = 0.009), device length (p = 0.006), and the interaction of cannula component and insertion angle (p = 0.007). On the transverse axis, no factors significantly influenced the device's echogenicity. The echogenicity of a device is an essential component of successful ultrasound-guided peripheral venous catheter placement. Optimizing catheter intrinsic factors such as components of the cannula and length, and extrinsic factor like the insertion angle should be considered in their design and use to reduce puncture failure rates.

#2294 Muscle ultrasound as a tool for morphofunctional assessment in patients with chronic kidney disease

Abstract Background and Aims The measurement of the rectus femoris of the quadriceps by ultrasound is used as a measure correlated with muscle mass, strength and functionality, being able to determine diameters and muscle area. Aims To assess the usefulness of ultrasound parameters of muscle mass and correlate it with age, gender, dynamometry, exercise, biochemistry and body composition by BIVA Method We evaluated 78 patients with ACKD stages 3,4,5(87.2%) and peritoneal dialysis (22.8%) with ultrasound with an echography device (Echographe Sonosite) measuring: transverse(A) and longitudinal(B) axes, ratio B/A and circumference and muscle area of the rectus femoris of the quadriceps according the usual technique. Likewise, we evaluate Hand-grip strength (HOGS), calf circumference and body-composition by BIA. Results We evaluated 78 patients with CKD: age 71.54 ± 11.76 years, 59% men and 48.7% DM. Dynapenia/presarcopenia =20.8% with lower muscle-ultrasound parameters, with significant direct correlation p0.01 with A, B, C and muscle mass area transverse diameter (A) = 0.99 ± 0.43, B (longitudinal diameter) = 2.63 ± 0.77, muscle circumference (C) = 6.33 ± 1.83, muscular area = 2.23 ± 1,23.(healthy-population A = 1.31 ± 1.2 cm, B = 3.21 ± 3.4 cm), ratio B/A = 2.97 ± 0.94. Right HGS = 27.22 ± 8.26 kg. Having exercised shows better sig parameters: A1.08 ± 0.45 vs 0.84 ± 0.35 p &amp;lt; 0.01, area 2.50 ± 1.27 vs 1.80 ± 1.02 p0.01 (B and C not sig) as well as age ≤75 vs &amp;gt;75 sig. better in all eco-muscular parameters. We found significant differences between men and women in all parameters as well as dynamometry, perimeter-calf and muscle mass by BIA, not in albumin, Hb or CRP. Overall normal vs low hand-grip-strength (HGS) showed better not significant echo-muscle values. CKD vs PD showed higher values in CKD but not significant. Global significant direct correlations of muscle area p &amp;lt; 0.01) with: HGS r0.324, calf-perimeter r0.30, MM r0.40, Phase-Angle r0.35, Cell mass (BCM) r0.39, and intracellular water (AIC) r0.38. Inverse sig p &amp;lt; 0.01 with B/A ratio. Conclusions

Keystone flap: Suitable option for coverage of soft tissue defect over Tendo Achilles following open repair

Introduction: Wound complications are not uncommon following operative Tendo Achilles repair. Patients presented in Plastic surgery department with soft tissue defect on Tendo achilles region with exposed Tendon. The paucity of tissue and poor blood circulation are main challenges for the reconstructive surgeon. The study aimed to evaluate the Keystone flap for soft tissue coverage of defects following Tendo achilles repair. Methods: This prospective study was conducted on January 2021 to December 2022 in Plastic surgery department of Rajshahi Medical College Hospital and all 12 cases were done by single surgeon. All patients had history of repair for ruptured Tendo Achilles and were presented with defect over Tendo achilles near or at its insertion, where the defect length was larger than width. Keystone flap type IIA was done for each defect. Results: Mean age of the study patients was 43.42 ±9.79 years. The highest dimension of wound was 36.80 (8 X 4.6) cm2 and flap was 66 (10 X 6.6) cm2. The range of advancement of flap was 3- 4.6 cm (mean: 3.43 ±0.54 cm) in transverse axis of leg. Mean duration of operative time was 53.58± 10.06 minutes. Follow up period was 3 months to measure outcome the flap. Conclusion: The keystone flap has high survivability rate with low complications rate providing with good functional outcome of joint. So, keystone flap is a suitable option for coverage of soft tissue defects following operative Tendo Achilles repair. J Bangladesh Coll Phys Surg 2024; 42: 155-160

Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy

Semiflexible fiber gels such as collagen and fibrin have unique nonlinear mechanical properties that play an important role in tissue morphogenesis, wound healing, and cancer metastasis. Optical tweezers microrheology has greatly contributed to the understanding of the mechanics of fibrous gels at the microscale, including its heterogeneity and anisotropy. However, the explicit relationship between micromechanical properties and gel deformation has been largely overlooked. We introduce a unique gel-stretching apparatus and employ it to study the relationship between microscale strain and stiffening in fibrin and collagen gels, focusing on the development of anisotropy in the gel. We find that gels stretched by as much as 15 % stiffen significantly both in parallel and perpendicular to the stretching axis, and that the parallel axis is 2–3 times stiffer than the transverse axis. We also measure the stiffening and anisotropy along bands of aligned fibers created by aggregates of cancer cells, and find similar effects as in gels stretched with the tensile apparatus. Our results illustrate that the extracellular microenvironment is highly sensitive to deformation, with implications for tissue homeostasis and pathology. Statement of significanceThe inherent fibrous architecture of the extracellular matrix (ECM) gives rise to unique strain-stiffening mechanics. The micromechanics of fibrous networks has been studied extensively, but the deformations involved in its stiffening at the microscale were not quantified. Here we introduce an apparatus that enables measuring the deformations in the gel as it is being stretched while simultaneously using optical tweezers to measure its microscale anisotropic stiffness. We reveal that fibrin and collagen both stiffen dramatically already at ∼10 % deformation, accompanied by the emergence of significant, yet moderate anisotropy. We measure similar stiffening and anisotropy in the matrix remodeled by the tensile apparatus to those found between cancer cell aggregates. Our results emphasize that small strains are enough to introduce substantial stiffening and anisotropy. These have been shown to result in directional cell migration and enhanced force propagation, and possibly control processes like morphogenesis and cancer metastasis.

Ultrasound Imaging in Football Players with Previous Multiple Ankle Sprains: Keeping a Close Eye on Superior Ankle Retinaculum.

The superior extensor ankle retinaculum (SEAR), a transversely fascial thickening positioned above the tibia-talar joint, serves as a crucial anatomical structure in ankle stability. The purpose of this study was to measure and compare by ultrasound (US) imaging the bilateral thickness and echogenicity of SEAR in football players with previous multiple ankle sprains (group 1) and healthy volunteers (group 2). A cross-sectional study was performed using ultrasound imaging to measure longitudinal and transversal axes using a new protocol in a sample of 50 subjects: 25 football players with previous multiple ankle sprains and 25 healthy subjects. The findings for SEAR thickness revealed statistically significant differences for both axes (p = 0.0011 and p = 0.0032) between the healthy side and the previously sprained side, and with the corresponding side of group 2 (p = 0.003 and p = 0.004). Moreover, in group 1, regarding the ROI echogenicity, a statistically significant difference was found between the sides (p = 0.0378). These findings suggest that the football players with previous ankle sprains showed a thicker and inhomogeneous SEAR on the sprain side, unveiling a remodeling of this structure compared to the other side and to the healthy volunteers. In these athletes, during US examination, one needs to keep "a US eye" on side-to-side SEAR comparisons.

Hippocampal subfields in remitted schizophrenia.

Current evidence of volume changes in hippocampal subdivisions in schizophrenia remains inconsistent, and few studies have investigated the relationship between regional hippocampal volumes and symptom remission. In this cross-sectional study, we recruited 31 patients with schizophrenia and 31 healthy controls (HCs). Symptomatic remission in schizophrenia was determined according to Remission in Schizophrenia Working Group criteria. The volumes of hippocampal longitudinal subregions and transverse subfields were measured using manual and automatic techniques, respectively. Between-group regional hippocampal volume differences were analyzed using multivariate analysis of covariance followed by univariate analysis of covariance. Compared with the HCs, the patients with schizophrenia had smaller bilateral heads and tails along the longitudinal axis; they also had reduced volumes of the bilateral CA1, CA3, CA4, GC-ML-DG, molecular layer, tail, left subiculum, left HATA, and right parasubiculum along the transverse axis in the hippocampus (all corrected p < 0.05). Furthermore, compared with the HCs and patients with remitted schizophrenia, the patients with nonremitted schizophrenia had smaller bilateral hippocampal tail subfields (corrected p < 0.05). Our results indicated that the pathophysiology and symptomatic remission of schizophrenia are related to changes in the volumes of hippocampal subdivisions. These volume changes might be clinically relevant as biomarkers for schizophrenia identification and treatment.

Generation of pure transverse spin and nontrivial polarization structures of beams by dielectric metasurface

Transverse spin, a spin component with unique characteristics, provides a new dimension for plenty of applications, such as optical trapping, imaging, and communication. Here, we analyze the pure transverse spin in the Bessel beam, which is solely present in the azimuthal direction. Based on a single layer dielectric metasurface, we efficiently generate Bessel beams with pure transverse spin in a compact optical system. As designed, the transverse spin is flexibly tunable by converting the polarization of the incident light. Furthermore, in the scattered Bessel beam, the local electromagnetic field oscillates around the transverse axis, which is perpendicular to the beam propagation. At certain positions, the local polarization ellipse degenerates into a perfect circle, resulting in a ring-periodic distribution of circularly polarized points (C points) in the beam. This suggests that the local polarization demonstrates a nontrivial periodic structure. This work deepens our understanding of spin-related physics and opens a new avenue for the study and application of transverse spins in ultracompact, flat, multifunctional nanophotonic platforms.

Large Ovarian Cyst - Laparoscopic Entry: A Case Report

This report is aimed at introducing a simple technique to improve safety in drainage of large ovarian cyst managed with laparoscopic techniques. A 31-year-old, nulliparous woman, presented with a massive unilocular ovarian cyst measuring 22.48 cm in height, 18.92 cm in transverse axis, and 8.03 cm antero posteriorly. She had a normal CA125 level. Entry was done with the open technique (Hasson's) at the midpoint between umbilicus and the xiphisternum (Lee Huang). Through this opening the cyst wall was separated by blind dissection to avoid damage to cyst wall. Then the cyst contents were drained with a Veress needle. Troche was inserted through the same incision and pneumoperitoneum was created allowing a routine cystectomy. The critical step in managing large cysts is safe entry and inducing pneumoperitoneum. Using a simple technique, could improve safety resulting in successful a successful outcome of laparoscopic techniques for large ovarian cysts.

Performance Evaluation of DGNSS Receiver for Dynamic Military Applications

In military applications, a highly accurate and precise navigation system is necessary for some ground-based combat system applications to navigate the vehicle and mark the location of the fuses and pickets laid by the mobile equipment. Few companies across the globe have developed expertise in manufacturing Global Navigation Satellite System (GNSS) receivers with Real Time Kinematics (RTK) capability along with integrated INS. On mobile equipment, it is not always possible to precisely place the Differential GNSS (DGNSS) antenna and GNSS receiver at the point for which the data needs to be marked. For such applications, lever arm calculation needs to be implemented. Also, due to uneven terrain conditions and slopes, the vehicle undulates up to 10o about its longitudinal and transverse axis. This dynamic condition induces considerable errors in the actual data. During the fuse laying process, there is also a continuous requirement for real-time location data in the GNSS-denied environment for a short period. INS was integrated with the GNSS receiver. We discuss test methodology for GNSS receiver performance evaluation. Experimentations were performed, taking into consideration these requirements. Data collected are also analyzed and discussed. Test results confirmed that the module is accurate with an accuracy of a few centimeters.

Assigning macromolecular meaning to nonlinear continuum rheology

The Oldroyd 8-constant continuum framework has yielded elegant analytical solutions for many polymer processing flows. However, continuum frameworks are silent on macromolecular structure. We can assign macromolecular meaning to the continuum constants by bridging continuum frameworks to the macromolecular theory of polymeric liquid dynamics. When the Oldroyd 8-constant framework has been bridged to rigid dumbbell theory (two-step), no higher order rheology was predicted (ν1=ν2=0). By higher order, we mean the nonlinear rheology. This troubled Bird (1972), motivating his modified Oldroyd 8-constant continuum framework, which does predict higher order rheology, to which meaning in rigid dumbbell theory is assigned. By two-step, we mean we get the three Jeffreys model constants from the macromolecular expression for the complex viscosity, and then solve five equations simultaneously for the five remaining constants. In this paper, in three steps, we bridge the Bird 8-constant framework to the more versatile rotarance theory (general rigid bead-rod theory). By three-step, we mean we get the three Jeffreys model constants from the macromolecular expression for the complex viscosity, and then solve three equations simultaneously for the next three, and finally solving two equation simultaneously for the remaining two higher order constants. By versatile, we mean accommodating any axisymmetric macromolecular structure (including the rigid dumbbell). We find the constants in the Bird 8-constant framework to be explicit functions of just one dimensionless macromolecular attribute: the ratio of the moment of inertia about the molecular axis, to the moment about either transverse axis. We thus assign macromolecular meaning to the higher order rheology. In passing, we also discover a new bridge to the Oldroyd 8-constant framework (three-step), which also assigns macromolecular meaning to the higher order rheology.

Mixed Convection of an Ag/Water Nanofluid in a Ventilated Square Cavity Containing Cold Blocks of Different Shapes

This research presents the results of a numerical study on mixed convection in a ventilated cavity with a central cold block of varying shapes. The direction of the forced flow of Ag/water nanofluid is perpendicular to the transverse axis (y) of the central cold block. Mixed convection is induced by cooling at the entrance of the ventilated cavity and uniformly heating its bottom wall. The governing equations for the flow of an incompressible Newtonian nanofluid are assumed to be two-dimensional, steady, and laminar. The finite volume method is employed for numerical simulations. A series of calculations are conducted to investigate the effects of key influencing factors: Reynolds number (Re = 100), Richardson number (Ri = 1), and nanoparticle volume fractions (0 ≤ ∅ ≤ 8%) on the enhancement of heat transfer. The impact of four different geometric shapes of the cold obstacle (circular, square, triangular, and elliptical) on fluid flow and heat transfer rate is also explored. The results indicate that an increase in nanoparticle volume fraction enhances the heat exchange rate in the cavity only when the geometric shape of the cold obstacle is circular. This is followed by square and triangular shapes, which approximately yield concordant results, and then the elliptical shape.

The three-dimensionally articulated oral apparatus of a Devonian heterostracan sheds light on feeding in Palaeozoic jawless fishes.

Attempts to explain the origin and diversification of vertebrates have commonly invoked the evolution of feeding ecology, contrasting the passive suspension feeding of invertebrate chordates and larval lampreys with active predation in living jawed vertebrates. Of the extinct jawless vertebrates that phylogenetically intercalate these living groups, the feeding apparatus is well-preserved only in the early diverging stem-gnathostome heterostracans. However, its anatomy remains poorly understood. Here, we use X-ray microtomography to characterize the feeding apparatus of the pteraspid heterostracan Rhinopteraspis dunensis (Roemer, 1855). The apparatus is composed of 13 plates arranged approximately bilaterally, most of which articulate from the postoral plate. Our reconstruction shows that the oral plates were capable of rotating around the transverse axis, but likely with limited movement. It also suggests the nasohypophyseal organs opened internally, into the pharynx. The functional morphology of the apparatus in Rhinopteraspis precludes all proposed interpretations of feeding except for suspension/deposit feeding and we interpret the apparatus as having served primarily to moderate the oral gape. This is consistent with evidence that at least some early jawless gnathostomes were suspension feeders and runs contrary to macroecological scenarios that envisage early vertebrate evolution as characterized by a directional trend towards increasingly active food acquisition.

Field, Habitus and Capitals from Narratives of Unemployed Men with Families

This article proposes as a transversal axis the analysis of masculinity in unemployed men with families. The aim of this article is to analyse the connotations of field, habitus and capitals based on the narratives of unemployed men with families. In order to answer this question, an interpretative paradigm research with an exploratory multiple qualitative case study design with seven lower middle-class men from Bogotá, Colombia, is proposed. By means of a semi-structured biographical interview in which categorical analysis was carried out after axial coding. In the results, the hegemonic expectations of the male gender are recognised as explicit, which are linked to the ideal of well-being that cannot be fulfilled. Social class is dynamic, maintaining constructed fields and hegemonic gender habitus apprehended and stripped of symbolic capital. These conditions together reveal that masculinity is constructed on the basis of hegemonic expectations of what is expected of men within the social structure. It generates tension to assume the change of the field, habitus and capitals at the moment of unemployment.

Experimental realization of entangled coherent states in two-dimensional harmonic oscillators of a trapped ion

Entangled coherent states play pivotal roles in various fields such as quantum computation, quantum communication, and quantum sensing. We experimentally demonstrate the generation of entangled coherent states with the two-dimensional motion of a trapped ion system. Using Raman transitions with appropriate detunings, we simultaneously drive the red and blue sidebands of the two transverse axes of a single trapped ion and observe multi-periodic entanglement and disentanglement of its spin and two-dimensional motion. Then, by measuring the spin state, we herald entangled coherent states of the transverse motions of the trapped ion and observe the corresponding modulation in the parity of the phonon distribution of one of the harmonic oscillators. Lastly, we trap two ions in a linear chain and realize Mølmer–Sørensen gate using two-dimensional motion.

Validating a Novel 2D to 3D Knee Reconstruction Method on Preoperative Total Knee Arthroplasty Patient Anatomies.

As advanced technology continues to evolve, incorporating robotics into surgical procedures has become imperative for precision and accuracy in preoperative planning. Nevertheless, the integration of three-dimensional (3D) imaging into these processes presents both financial considerations and potential patient safety concerns. This study aims to assess the accuracy of a novel 2D-to-3D knee reconstruction solution, RSIP XPlan.ai™ (RSIP Vision, Jerusalem, Israel), on preoperative total knee arthroplasty (TKA) patient anatomies. Accuracy was calculated by measuring the Root Mean Square Error (RMSE) between X-ray-based 3D bone models generated by the algorithm and corresponding CT bone segmentations (distances of each mesh vertex to the closest vertex in the second mesh). The RMSE was computed globally for each bone, locally for eight clinically relevant bony landmark regions, and along simulated bone cut contours. In addition, the accuracies of three anatomical axes were assessed by comparing angular deviations to inter- and intra-observer baseline values. The global RMSE was 0.93 ± 0.25 mm for the femur and 0.88 ± 0.14 mm for the tibia. Local RMSE values for bony landmark regions were 0.51 ± 0.33 mm for the five femoral landmarks and 0.47 ± 0.17 mm for the three tibial landmarks. The RMSE along simulated cut contours was 0.75 ± 0.35 mm for the distal femur cut and 0.63 ± 0.27 mm for the proximal tibial cut. Anatomical axial average angular deviations were 1.89° for the trans epicondylar axis (with an inter- and intra-observer baseline of 1.43°), 1.78° for the posterior condylar axis (with a baseline of 1.71°), and 2.82° (with a baseline of 2.56°) for the medial-lateral transverse axis. The study findings demonstrate promising results regarding the accuracy of XPlan.ai™ in reconstructing 3D bone models from plain-film X-rays. The observed accuracy on real-world TKA patient anatomies in anatomically relevant regions, including bony landmarks, cut contours, and axes, suggests the potential utility of this method in various clinical scenarios. Further validation studies on larger cohorts are warranted to fully assess the reliability and generalizability of our results. Nonetheless, our findings lay the groundwork for potential advancements in future robotic arthroplasty technologies, with XPlan.ai™ offering a promising alternative to conventional CT scans in certain clinical contexts.

Whole-brain spatial organization of hippocampal single-neuron projectomes.

Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 single-neuron projectomes of mouse HIP and classified 43 projectome subtypes with distinct projection patterns. The number of projection targets and axon-tip distribution depended on the soma location along HIP longitudinal and transverse axes. Many projectome subtypes were enriched in specific HIP subdomains defined by spatial transcriptomic profiles. Furthermore, we delineated comprehensive wiring diagrams for HIP neurons projecting exclusively within the HIP formation (HPF) and for those projecting to both intra- and extra-HPF targets. Bihemispheric projecting neurons generally projected to one pair of homologous targets with ipsilateral preference. These organization principles of single-neuron projectomes provide a structural basis for understanding the function of HIP neurons.