#2294 Muscle ultrasound as a tool for morphofunctional assessment in patients with chronic kidney disease

Abstract

Abstract Background and Aims The measurement of the rectus femoris of the quadriceps by ultrasound is used as a measure correlated with muscle mass, strength and functionality, being able to determine diameters and muscle area. Aims To assess the usefulness of ultrasound parameters of muscle mass and correlate it with age, gender, dynamometry, exercise, biochemistry and body composition by BIVA Method We evaluated 78 patients with ACKD stages 3,4,5(87.2%) and peritoneal dialysis (22.8%) with ultrasound with an echography device (Echographe Sonosite) measuring: transverse(A) and longitudinal(B) axes, ratio B/A and circumference and muscle area of the rectus femoris of the quadriceps according the usual technique. Likewise, we evaluate Hand-grip strength (HOGS), calf circumference and body-composition by BIA. Results We evaluated 78 patients with CKD: age 71.54 ± 11.76 years, 59% men and 48.7% DM. Dynapenia/presarcopenia =20.8% with lower muscle-ultrasound parameters, with significant direct correlation p0.01 with A, B, C and muscle mass area transverse diameter (A) = 0.99 ± 0.43, B (longitudinal diameter) = 2.63 ± 0.77, muscle circumference (C) = 6.33 ± 1.83, muscular area = 2.23 ± 1,23.(healthy-population A = 1.31 ± 1.2 cm, B = 3.21 ± 3.4 cm), ratio B/A = 2.97 ± 0.94. Right HGS = 27.22 ± 8.26 kg. Having exercised shows better sig parameters: A1.08 ± 0.45 vs 0.84 ± 0.35 p < 0.01, area 2.50 ± 1.27 vs 1.80 ± 1.02 p0.01 (B and C not sig) as well as age ≤75 vs >75 sig. better in all eco-muscular parameters. We found significant differences between men and women in all parameters as well as dynamometry, perimeter-calf and muscle mass by BIA, not in albumin, Hb or CRP. Overall normal vs low hand-grip-strength (HGS) showed better not significant echo-muscle values. CKD vs PD showed higher values in CKD but not significant. Global significant direct correlations of muscle area p < 0.01) with: HGS r0.324, calf-perimeter r0.30, MM r0.40, Phase-Angle r0.35, Cell mass (BCM) r0.39, and intracellular water (AIC) r0.38. Inverse sig p < 0.01 with B/A ratio. Conclusions