This study was conducted as an attempt to find out the effect of applying Transactional Strategies Instruction (TSI) on students' reading comprehension. This study used an experimental design. The population were students from SMA Negeri 1 Onan Ganjang. The sample for this study consisted of sixty first-graders at a senior high school. Two randomly generated groups—one for the experimental group and one for the control group—were used. The control group was taught without applying TSI, while the experimental group was taught with TSI. The instrument for collecting data was an objective multiple-choice test, which consisted of 40 items. The data were analyzed using a t-test. This study shows that teaching reading comprehension by using TSI has a more significant effect than teaching without it.