Yield to pedestrians has become a new trend of civilized transportation in the metropolis. In order to evaluate the influence of yield behavior on the comprehensive operation efficiency of signalized intersections in arterial, the efficiency of the subject who gives way and the subject who is given up in the process of yielding to pedestrians was considered in this study, and the comprehensive operation evaluation of intersection in arterial was given. First, based on the rule of pedestrians yield, the concept of a safe headway gap of pedestrians was introduced in the process of conflict analysis of traffic flows at the intersection, and 3 situations were discussed, which are no yield, yield to 1 flow and 2 flows, to calculate the departure rate of traffic flow at the intersection. Furthermore, models of 3 evaluation indices were established, which are number of people passing per unit time, average delay per people, and average yield number per people at intersection. Moreover, the entropy weight method was taken to decide the weight of these 3 indices, and to calculate the comprehensive efficiency evaluation of intersection operation, with the standardized matrix. Finally, case study work was carried out to evaluate the comprehensive efficiency of 4 types of intersections in arterial considering pedestrians yield rule, which is the intersection between arterial and arterial (IAA), intersection between arterial and subarterial (IAS), intersection with one-time (IAA-1, IAS-1), and two-time (IAA-2, IAS-2) crossing of pedestrians. The relevant results show that the impact of an increase in the number of pedestrians on the combined efficiency of arterial intersections can vary dramatically in different scenarios. Therefore, in the implementation process of “yielding to pedestrians,” the flow fluctuation characteristics and channelization of each intersection should be taken into account, and the corresponding phase changes should be based on pedestrian and vehicle volumes to improve the efficiency of all parts, such as pedestrians and drivers.