Tract Of Dogs Research Articles

Lysozyme in ulcerative colitis.

Editorial1 October 1952LYSOZYME IN ULCERATIVE COLITISP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBoth the etiology and the therapeutic management of ulcerative colitis present many unsolved problems, and additional information bearing on this subject is badly needed. Recent observations indicating a relationship of lysozyme to this disease naturally have aroused much interest.Lysozyme is a mucolytic and bacteriolytic enzyme (or rather a group of enzymes), first isolated and described by Fleming in egg white, and also in human tears and other secretions. Lysozyme is a crystallizable basic protein of relatively low molecular weight, optimally active at a pH of about 6.0. It causes hydrolysis of certain mucopolysaccharides, and it can be titrated by...1 MeyerHahnel KE: The estimation of lysozyme by a viscosimetric method, J. Biol. Chem. 163: 723, 1946. CrossrefMedlineGoogle Scholar2 Meyer K: Lysozyme activity in ulcerative alimentary disease. I. Lysozyme in peptic ulcer, Am. J. Med. 5: 482-495, 1948. CrossrefMedlineGoogle Scholar3 Prudden JF: The effect of orally and intra-arterially administered lysozyme on the canine gastrointestinal mucosa, Am. J. M. Sc. 219: 291, 1950. CrossrefMedlineGoogle Scholar4 Kirsner JB: Lysozyme and ulcerative colitis, J. A. M. A. 148: 1145, 1952 (correspondence). CrossrefGoogle Scholar5 Lobstein OF: Lysozyme and ulcerative colitis, J. A. M. A. 149: 186, 1952 (correspondence). CrossrefGoogle Scholar6 Glass GB: Observations on the treatment of human gastric and colonic mucus with lysozyme, J. Clin. Investigation 29: 12-19, 1950. CrossrefMedlineGoogle Scholar7 Meyer K: Lysozyme activity in ulcerative alimentary disease. II. Lysozyme activity in chronic ulcerative colitis, Am. J. Med. 5: 496-502, 1948. CrossrefMedlineGoogle Scholar8 Gray SJ: Treatment of ulcerative colitis and regional enteritis with ACTH. Significance of fecal lysozyme, Arch. Int. Med. 87: 646-662, 1951. CrossrefGoogle Scholar9 Gray SJ: Treatment of ulcerative colitis with corticotropin (ACTH) and cortisone. A two year follow up, J. A. M. A. 148: 1489-1497, 1952. CrossrefMedlineGoogle Scholar10 Grace WJ: Studies of the human colon. I. Variations in concentration of lysozyme with life situations and emotional states, Am. J. M. Sc. 217: 241, 1949. CrossrefMedlineGoogle Scholar11 Sammons HG: Mucinases in ulcerative colitis, Lancet 2: 239-240, 1951. CrossrefMedlineGoogle Scholar12 Prudden JF: Lysozyme titers in regional enteritis, miscellaneous tissues, microörganisms and excreta, Proc. Soc. Exper. Biol. and Med. 72: 220, 1949. CrossrefMedlineGoogle Scholar13 Combined Staff Clinics, Am. J. Med. 6: 481-494 (April) 1949. MedlineGoogle Scholar14 Gray SJ: Studies on lysozyme in ulcerative colitis, Gastroenterology 16: 687-696, 1950. CrossrefMedlineGoogle Scholar15 Moeller HC: Lysozyme production in response to injury of the gastrointestinal tract in dogs, Proc. Soc. Exper. Biol. and Med. 76: 159-161, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLysozyme Bibliography: 1922–1972Ulcerative Colitis 1 October 1952Volume 37, Issue 4Page: 813-816KeywordsEnzymesEtiologyLysozymeProteinsUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...

Lysozyme production in response to injury of gastrointestinal tract in dogs.

Summary1. Lysozyme is produced in moderately large amounts by the gastrointestinal tract of dogs subjected to chronic stimulation with Mecholyl. The increase in lysozyme is demonstrable in the bloody diarrheal stools of intact animals and in material aspirated from isolated pouches of colon. 2. Cautery of canine rectum stimulates the local production of large amounts of lysozyme within 5 1/2 hours after injury. 3. The rapid production of lysozyme by injured bowel suggests that it is an early accompaniment of the inflammatory reaction and that its presence is a reflection rather than a cause of ulcerative alimentary disease.

Heterotopic Bone Formation Produced by Epithelial Transplants From Urogenital Tract of Dogs, Rabbits, Guinea-Pigs and Cats: With Notes on Apparent Inhibitory Effect of Parathyroidectomy on Bone Formation

Heterotopic Bone Formation Produced by Epithelial Transplants From Urogenital Tract of Dogs, Rabbits, Guinea-Pigs and Cats: With Notes on Apparent Inhibitory Effect of Parathyroidectomy on Bone Formation

Peptic ulcer following loss of pancreatic secretion through a fistula: An experimental study

Specimens of the content of the upper part of the gastro-intestinal tract of dogs were collected during fasting and after the administration of various diets. Following the production of a pancreatic fistula in these animals, no change in the pH of the gastric content was detected, but the duodenal pH during fasting was more variable and after ingestion of protein and carbohydrate meals a lower value was reached and was maintained for longer periods than normally. The latter observation was sometimes noted in the jejunum after a protein diet. Peptic ulcer occurred in 42 per cent of the animals in which a pancreatic fistula was made. There appeared to be an increase in the amount of material obtained from the stomach, duodenum, and jejunum during fasting and after different test meals, as well as an increased in the acidity of the material, in the animals in which ulcer was found at necropsy.

Effects, on the Upper Urinary Tract in Dogs, of an Incompetent Uretero-Vesical Valve

Effects, on the Upper Urinary Tract in Dogs, of an Incompetent Uretero-Vesical Valve

EFFECT OF LACTOSE ON RICKETS IN RATS

Lactose has been shown to increase the acidity of the intestinal tract. Rickets seems to be associated with an alkaline reaction in the intestinal tract. Coupling these facts led to this investigation to determine the effect of lactose on rickets. A connection between increased alkalinity of the intestinal tract and rickets has been pointed out by several investigators. Zucker and Matzner 1 noted a lowering of the fecal ph of rachitic rats when antirachitic substances were added to the diet. Abrahamson and Miller 2 suggested that the lowering of the acidity of the intestinal tract on a rachitic diet, with the resulting formation of insoluble calcium phosphate, might be an important factor in the deficiency of calcium absorption and deposition on rachitic diets. Grayzel and Miller 3 found that the entire intestinal tract of dogs showed acidity on all the diets used except the rickets-producing diet, which caused a rise

Introduction of Iodised Oil into Respiratory Tract of Dog.

Introduction of Iodised Oil into Respiratory Tract of Dog.