Lysozyme in ulcerative colitis.

Abstract

Editorial1 October 1952LYSOZYME IN ULCERATIVE COLITISP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBoth the etiology and the therapeutic management of ulcerative colitis present many unsolved problems, and additional information bearing on this subject is badly needed. Recent observations indicating a relationship of lysozyme to this disease naturally have aroused much interest.Lysozyme is a mucolytic and bacteriolytic enzyme (or rather a group of enzymes), first isolated and described by Fleming in egg white, and also in human tears and other secretions. Lysozyme is a crystallizable basic protein of relatively low molecular weight, optimally active at a pH of about 6.0. It causes hydrolysis of certain mucopolysaccharides, and it can be titrated by...1 MeyerHahnel KE: The estimation of lysozyme by a viscosimetric method, J. Biol. Chem. 163: 723, 1946. CrossrefMedlineGoogle Scholar2 Meyer K: Lysozyme activity in ulcerative alimentary disease. I. Lysozyme in peptic ulcer, Am. J. Med. 5: 482-495, 1948. CrossrefMedlineGoogle Scholar3 Prudden JF: The effect of orally and intra-arterially administered lysozyme on the canine gastrointestinal mucosa, Am. J. M. Sc. 219: 291, 1950. CrossrefMedlineGoogle Scholar4 Kirsner JB: Lysozyme and ulcerative colitis, J. A. M. A. 148: 1145, 1952 (correspondence). CrossrefGoogle Scholar5 Lobstein OF: Lysozyme and ulcerative colitis, J. A. M. A. 149: 186, 1952 (correspondence). CrossrefGoogle Scholar6 Glass GB: Observations on the treatment of human gastric and colonic mucus with lysozyme, J. Clin. Investigation 29: 12-19, 1950. CrossrefMedlineGoogle Scholar7 Meyer K: Lysozyme activity in ulcerative alimentary disease. II. Lysozyme activity in chronic ulcerative colitis, Am. J. Med. 5: 496-502, 1948. CrossrefMedlineGoogle Scholar8 Gray SJ: Treatment of ulcerative colitis and regional enteritis with ACTH. Significance of fecal lysozyme, Arch. Int. Med. 87: 646-662, 1951. CrossrefGoogle Scholar9 Gray SJ: Treatment of ulcerative colitis with corticotropin (ACTH) and cortisone. A two year follow up, J. A. M. A. 148: 1489-1497, 1952. CrossrefMedlineGoogle Scholar10 Grace WJ: Studies of the human colon. I. Variations in concentration of lysozyme with life situations and emotional states, Am. J. M. Sc. 217: 241, 1949. CrossrefMedlineGoogle Scholar11 Sammons HG: Mucinases in ulcerative colitis, Lancet 2: 239-240, 1951. CrossrefMedlineGoogle Scholar12 Prudden JF: Lysozyme titers in regional enteritis, miscellaneous tissues, microörganisms and excreta, Proc. Soc. Exper. Biol. and Med. 72: 220, 1949. CrossrefMedlineGoogle Scholar13 Combined Staff Clinics, Am. J. Med. 6: 481-494 (April) 1949. MedlineGoogle Scholar14 Gray SJ: Studies on lysozyme in ulcerative colitis, Gastroenterology 16: 687-696, 1950. CrossrefMedlineGoogle Scholar15 Moeller HC: Lysozyme production in response to injury of the gastrointestinal tract in dogs, Proc. Soc. Exper. Biol. and Med. 76: 159-161, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLysozyme Bibliography: 1922–1972Ulcerative Colitis 1 October 1952Volume 37, Issue 4Page: 813-816KeywordsEnzymesEtiologyLysozymeProteinsUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...