Ulcerative colitis; therapeutic effects of corticotropin (ACTH) and cortisone in 120 patients.

Abstract

Article1 August 1954ULCERATIVE COLITIS: THERAPEUTIC EFFECTS OF CORTICOTROPIN (ACTH) AND CORTISONE IN 120 PATIENTSJOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P., WALTER L. PALMER, M.D., Ph.D., F.A.C.P.JOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.Search for more papers by this author, WALTER L. PALMER, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe effects of corticotropin (ACTH) and cortisone in ulcerative colitis have been characterized as beneficial,1-5 indifferent6-8 and unfavorable.9-14 Numerous studies also have emphasized the complications of therapy and the recurrences.15-20 The observation of 40 patients in 19511 indicated that, while ACTH and cortisone do not cure ulcerative colitis, they may be useful adjuncts, initiating rapid and occasionally dramatic clinical improvement. The present report summarizes our experience with corticotropin and cortisone in 120 patients with ulcerative colitis observed during the past four years.PATIENTS STUDIEDGeneral Data:The series includes 65 females and 55 males; the majority were between 20...Bibliography1. KirsnerPalmerKlotz JBWLAP (a) : ACTH and cortisone in chronic ulcerative colitis. A comparison of clinical effects, J. Lab. and Clin. Med. 36: 846, 1950. (b) Kirsner, J. B., and Palmer, W. L.: ACTH in ulcerative colitis. Report of progress, Gastroenterology 18: 143, 1951. (c) Kirsner, J. B.: Discussion of "ACTH in chronic ulcerative colitis," Proc. Second Clinical ACTH Conference, 1951, The Blakiston Co., Philadelphia, p. 500. (d) Kirsner, J. B., and Palmer, W. L.: Effect of corticotropin (ACTH) in chronic ulcerative colitis. Observations in forty patients, J. A. M. A. 147: 541, 1951. MedlineGoogle Scholar2. 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(Presented at Midwest Regional Meeting, American College of Physicians, Milwaukee, Wisconsin, November 21, 1953.)From the Department of Medicine, University of Chicago.†This study was supported in part by the Wallach Fund for Gastrointestinal Research.Dr. David Klein, of Wilson Laboratories, Chicago, Illinois, very generously supplied much of the corticotropin (ACTH).Merck and Company provided a portion of the cortisone. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInflammatory bowel disease part II: Clinical and therapeutic aspectsBlood eosinophilia and ulcerative colitis--influence of ethnic origin.Clinical Observations on Inflammatory Bowel DiseaseThe Treabnent of Ulcerative ColitisChronic ulcerative colitis in elderly patientsEosinophilia in Peripheral Blood and Inflammatory Exudate in Non-specific ProctocolitisImmediate and Prolonged Therapeutic Effects of Corticotrophin and Adrenal Steroids in Ulcerative ColitisEOSINOPHIL LEUCOCYTES IN ULCERATIVE COLITISCORTICOTROPIN (ACTH) AND THE ADRENAL STEROIDS IN THE MANAGEMENT OF ULCERATIVE COLITIS: OBSERVATIONS IN 240 PATIENTS*†JOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER L. PALMER, M.D., F.A.C.P., JEAN A. SPENCER, M.D., RICHARD O. BICKS, M.D., CHARLES F. 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ABBOTT, M.D., HARVEY KRIEGER, M.D., STANLEY LEVEY, Ph.D.THE USE OF HYDROCORTISONE IN ULCERATIVE COLITIS: PRELIMINARY OBSERVATIONS 1 August 1954Volume 41, Issue 2Page: 232-250KeywordsAdrenocorticotropic hormoneResearch fundingUlcerative colitis Issue Published: 1 August 1954 PDF downloadLoading ...