Problems in the management of ulcerative colitis, with particular reference to ACTH and the adrenal steroids.

Abstract

Article1 January 1957PROBLEMS IN THE MANAGEMENT OF ULCERATIVE COLITIS, WITH PARTICULAR REFERENCE TO ACTH AND THE ADRENAL STEROIDSMANUEL SKLAR, M.D., JOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER L. PALMER, M.D., F.A.C.P.MANUEL SKLAR, M.D.Search for more papers by this author, JOSEPH B. KIRSNER, M.D., F.A.C.P.Search for more papers by this author, WALTER L. PALMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONUlcerative colitis is a serious disabling disease of variable course, with remissions and exacerbations at unpredictable intervals. Prior to adrenal corticotherapy, conventional medical management, although helpful in the majority of the patients, seldom produced dramatic results. In a series1of 100 cases reported in 1948, 53 patients were estimated to have benefited from medical therapy. Fourteen patients died; the most common cause of death (nine patients) was peritonitis secondary to perforation of the bowel. In a recent survey2of 180 cases treated with ACTH, cortisone, hydrocortisone and related compounds in the years 1950 through 1955, a satisfactory, often very...Bibliography1. KirsnerPalmerMaimonRicketts JBWLSHWE: Clinical course of chronic non specific ulcerative colitis, J. A. M. A. 137: 922, 1948. CrossrefMedlineGoogle Scholar2. KirsnerSklarPalmer JBMWL: The use of ACTH, cortisone, hydrocortisone, and related compounds in the management of ulcerative colitis, Am. J. Med., to be published. Google Scholar3. GrimesBoudouresJacksonGoldman OFPCTL: Surgical treatment of ulcerative colitis, Am. J. Surg. 90: 228, 1955. CrossrefMedlineGoogle Scholar4. WirtsRehfussYantes CWMEHA: Long term results in corticotropin-treated ulcerative colitis, J. A. M. 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Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication June 25, 1956.From the Department of Medicine, University of Chicago, Chicago, Illinois.†United States Public Health Service Research Fellow of the National Cancer Institute, Department of Medicine, University of Chicago.This study was supported in part by the Wallach Fund for Gastrointestinal Research (University of Chicago).Requests for reprints should be addressed to Joseph B. Kirsner, M.D., Department of Medicine, The University of Chicago, Chicago 37, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInflammatory bowel disease part II: Clinical and therapeutic aspectsThe Therapeutic Role of Corticotropin and the Corticosteroids in Nonspecific Inflammatory Disease of the IntestineWALTER L. PALMER, M.D., M.A.C.P., Richard T. CraneProphylaxis in patients receiving adrenal steroid therapyAUTOIMMUNE DISEASE OF THE THYROID AND COLON, WITH A REPORT OF A CASE OF CHRONIC ULCERATIVE COLITIS IN ASSOCIATION WITH HASHIMOTO'S DISEASE AND PENICILLIN ALLERGYRectal hydrocortisone for ulcerative colitis refractory to oral corticosteroidsCORTICOTROPIN (ACTH) AND THE ADRENAL STEROIDS IN THE MANAGEMENT OF ULCERATIVE COLITIS: OBSERVATIONS IN 240 PATIENTS*†JOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER L. PALMER, M.D., F.A.C.P., JEAN A. SPENCER, M.D., RICHARD O. BICKS, M.D., CHARLES F. JOHNSON, M.D.Complications of adrenocortical therapyObservations on the Course of Nonspecific Ulcerative ColitisThe Present Status of the Treatment of Chronic Ulcerative Colitis with Steroid HormonesGeneralized scleroderma associated with chronic ulcerative colitisThe Use of ACTH and Adrenocorticosteroids in Diseases of the Digestive SystemUlcerative Colitis; Observations on Its Etiology, Course and Management 1 January 1957Volume 46, Issue 1Page: 1-20KeywordsAdrenocorticotropic hormoneColitisEdemaHormonal therapyHypertensionPeritonitisPsychosesSteroid therapySteroidsUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 January 1957 Copyright & PermissionsCopyright ©, 1957, by The American College of PhysiciansPDF downloadLoading ...