Tow Groups Research Articles

Effect study's the role of serum vitamin D3 level in Hashimoto's thyroiditis disease

Background: Hashimoto's thyroiditis (HT) is classify within the autoimmune disease of thyroid gland caused by diffuse of special lymphocytes into thyroid, lymphocyte product's special antibody lead to destroy gland tissue . Vitamin D (vit.D) is steroid substance bind with special receptor to have it's functions .Vit.D3 has various function in human body such as non skeletal function of vit.D3 is gene regulation that involve in autoimmune disease.Materials and methods: Present study include collection involved tow groups , HT disease group and healthy individuals , then measured vit.D3 , T4, TSH and anti-TPO levels for all groups.Results: Study result's shown after comparison between HT patients group and control group the reduction of serum vit.D level at HT group with present hypofunction of thyroid gland .Conclustion : Concluded this study to must be serumvit.D3 level within normal rang due to vit.D3 has function to regulation genes that effect on autoimmune diseases such as HT via modulation of immune cells secretions that lead to thyroid cells destroy.

A retrospective study comparing oral health in cancer patients and healthy people.

The purpose of this study was to investigate the relationship between oral and dental health in cancer patients and control group, which was conducted in Tabriz Shahid Gazi hospital. A researchers-made and validated questionnaire including oral and dental health criteria, was filled by the cancer patients (201 cases) and healthy controls (199 cases). Then, the results of the study were analyzed by SPSS software, and reported as Odds ratios (95 % confidence intervals) in tow groups. The results indicate that comparison of filled tooth, tooth extraction, dental caries, and gingival problems including bleeding, gum surgery and inflammation in cancer and controls were significantly meaningful. However, the comparison between the two groups was not significant in terms of the type of the tooth (natural or denture) and the number of daily toothbrushes, but they were considered as risk factors due to statistical results. Environmental factors, and especially oral hygiene, can play an important role in the incidence of different cancers. Among these, the type of oral microorganisms, and their overgrowth and released antigens should be studied further in the emergence of different kinds of cancer in humans.

Medical imaging in problem-based learning and impact on the students: A cross-sectional study.

To investigate the medical students' performance with and perception towards different multimedia medical imaging tools. The cross-sectional study was conducted at the College of Medicine, Qassim University, Saudi Arabia, from 2019 to 2020, and comprised third year undergraduate medical students during the academic year 2019-2020. The students were divided into tow groups. Those receiving multimedia-enhanced problem-based learning sessions were in intervention group A, while those receiving traditional problem-based learning sessions were in control group B. Scores of the students in the formative assessment at the end of the sessions were compared between the groups. Students' satisfaction survey was also conducted online and analysed. Data was analysed using SPSS 21. Of the 130 medical students, 75(57.7%) were males and 55(42.3%) were females. A significant increase in the mean scores was observed for both male and female students in group A compared to those in group B (p<0.05). The perception survey was filled up by 100(77%) students, and open-ended comments were obtained from 88(88%) of them. Overall, 69(74%) subjects expressed satisfaction with the multimedia-enhanced problem-based learning sessions. Radiological and pathological images enhanced the students' understanding, interaction and critical thinking during problem-based learning sessions.

Relationship between vitamin D and TPO antibody in Hashimoto's thyroiditis

Introduction: Hashimoto's thyroiditis is autoimmune disease that effect on thyroid gland tissue via penetration some special white blood cells (called lymphocyte) into thyroid gland and it is act to product specific antibodies act to damage the thyroid cells. Vitamin D is fat soluble vitamin, it is from steroid compounds derivatives and act after binding with its receptor in target cell. Vitamin D has many functions, but the important function is regulation factor on gene level, so it include in regulation of autoimmune diseases severity. Objective: This study aimed to explain the role vitamin D deficiency on severity of Hashimoto's thyroiditis via it's effect on TPO-Ab production. Method: The current study involved compare tow groups Hashimoto's thyroiditis with vitamin D deficiency as group 1 and Hashimoto’s thyroiditis without vitamin D deficiency group 2. The serum specimens of all individuals used to measure anti TPO-Ab, T4, TSH and vitamin D levels via TOSOH instrument. Results: This study result's explain after comparison between Hashimoto's thyroiditis with vitamin D deficiency group and Hashimoto's thyroiditis without vitamin D deficiency group the elevation of anti- TPO-Ab levels with sever hypothyroidism in Hashimoto's thyroiditis with vitamin D deficiency group more than other group.

A Comparison of Bevacizumab Plus TAS-102 and TAS-102 Monotherapy for Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

BackgroundsAs a new oral chemotherapy drug, TAS-102 is currently recommended as the third-line treatment for metastatic colorectal cancer (mCRC). Recently, studies have reported the efficacy of TAS-102 combined with bevacizumab in colon cancer patients after standard treatment fails. Here, we evaluated the efficacy and safety of TAS-102 combined with bevacizumab versus TAS-102 as a single agent by a systematic review and a meta-analysis.MethodsPubMed, Web of Science and Cochrane libraries were searched. Studies involving bevacizumab combined with TAS-102 in mCRC were included. Study characteristics (author, year of publication, country et al.), efficacy (disease control rate(DCR), progression-free survival(PFS), overall survival(OS)) and adverse effects were extract from studies. Forest plots were created based on Cox model analysis.ResultsAfter screening 550 studies, a total of 3 studies were included, which compared the safety and effectiveness of TAS-102 with or without bevacizumab. Analysis based on Cox regression showed that the combined treatment group had advantages in 6-month (OR= 2.93, 95% CI: 1.72 to 5.00, P<0.0001), 12-month(OR= 2.18, 95% CI: 1.24 to 3.81, P=0.006), and 18-month (OR=3.08, 95% CI: 1.34 to 7.12, P=0.008) OS. The combined treatment group demonstrated superiority in 6-month PFS rates (OR= 2.50, 95% CI: 1.18 to 5.31, P=0.02). The incidence of thrombocytopenia in the dual-drug treatment group was higher (OR= 1.96, 95% CI: 1.14 to 3.36 P=0.01). The proportion of serious adverse events were similar in tow groups (OR= 1.01, 95% CI: 0.76 to 1.34 P=0.93).ConclusionBevacizumab combined with TAS-102 could improve the prognosis of patients with mCRC who have failed standard treatment. In terms of side effects, the addition of bevacizumab did not increase serious adverse reactions, but the occurrence of thrombocytopenia was worth noting.

Absorbable Versus non Absorbable Suspintion Suture in Patient with Obstructive Sleep Apnea

Absorbable versus non absorbable suspintion suture in patient with obstructive sleep apnea up to the best of our knowledge, there is no evidence knowledge comparing absosbable suture and non absorbable suspintion suture.in patient with obstructive sleep apnea compare between absorbable versus non absorbable suspintion suture in patient with obstructive sleep apnea. A prospective randomized clinical study carried out in benha university hospital from november 2018 to august 2019. Included 36patients who underwent sleep surgeries; anteriore platoplasty .hyoid expantion patients were allocated into tow groups; a, b,). The groups(a) absorbable suspintion sutura compared non absorabable suspintion suturae in patient with osa, regardling the apne hypopnea index(ah) snoring score epworth scaling scale(epss) pain score and satistifacion of the patient.mean pain score was significantly lower in-group a and higher in-group b snoring score give more significant increase ingroup a more than group b .and lowest oxygen saturation incrase significant after absorbable suture groupa more than non absorbable suture groupb,in this study, postoperative pain scores significantly decreased after 1 week postoperative when compared with that reported in the 1st day and pain was controlled by oral analgesic only in first days. Regarding the epss values, they showed significant improvement after absorbable sutures and after non-absorbable sutures .both absorbable and non-absorbable suspension sutures are safe, fast, have low cost, easily applicable and effective procedures for treatment of osa.both absorbable and non absorbable sutures resulted in significant improvement of objective and subjective parameters in patients with osa.

Study of Gastroesophageal Reflex Disease in adult Type II Diabetes Mellitus Patients with Upper Gastrointestinal Symptoms

Gastrointestinal symptoms are relatively common in clinical practice in patients with type II diabetes mellitus. type II DM has been described as possible risk factor for the development of gastroesophageal reflux disease, in this study we aim to detect the prevalence of GRED in symptomatic patients with type II DM , also to see the accuracy of reflex disease questionnaire ( RDQ) in the diagnosis of GERD in patients with type II DM in relation to the esophagogastroduodenoscopy finding and to study the relation of autonomic neuropathy to the prevalence and stages of GERD in diabetic patients . Method: A ninety patients with upper gastrointestinal symptoms was divided in to tow groups according to whether had type II DM or not and then each group involved in a two stage process (a ) – a RDQ , ( b) – OGD . And patients in the DM group underwent another step to detect diabetic neuropathy by a bed side clinical test . Results: The prevalence of esophagitis in this study was higher in the DM group . RDQ had a statistical significance in detecting esophagitis in the DM group . There is no relation of autonomic neuropathy to the prevalence of GERD in diabetic patients . . Conclusion: The prevalence of GERD was high in patients with type II DM , RDQ is a sensitive tool for the diagnosis of GERD in diabetic pateints , Autonomic neuropathy did not increase prevalence of esophagitis in diabetic patients .

COMPARISON OF EFFECTIVENESS OF STANDARD TRIPLE THERAPY VERSUS BISMUTH-BASED THERAPY FOR THE MANAGEMENT OF PEPTIC ULCER DISEASE DUE TO HELICOBACTER PYLORI

Objective: Helicobacter pylori is the primary agent causing peptic ulcer, therefore imposing a significant impact on health elated quality of life, consequently affecting nearly 50% of global population. The objective of this study is to determine and assess the effectiveness of triple therapy versus bismuth containing quadruple therapy for eradication of peptic ulcer disease due to H. pylori.&#x0D; Methods: A prospective randomized observational study was conducted at Princess Esra Hospital, Department of Gastroenterology for a period of 6 months. A total of 100 patients were randomly allocated in tow groups. The data were assessed using various parameters. H. pylori eradication was validated using rapid urease test done at the start treatment 4 weeks after the completion.&#x0D; Results: A total of 100 patients were recruited in the study. In triple therapy group medication adherence rate was found to be 82% in triple and 92% in quadruple therapy. The eradication rate was assessed using Chi-square test it was 82% and 97% in triple and quadruple therapy group, respectively. Hence, the difference was found to be statistically significant value &lt;0.005. In addition, increased recurrence rate has been observed in triple therapy (17%) in contrast with quadruple therapy (2%).&#x0D; Conclusion: Addition of bismuth to significant triple therapy improves cure rates with minimal side effects. Interestingly, we observed that when bismuth was added, it produced a significant higher eradication rate (97%) when compared with standard triple therapy (82%). According to our study, bismuth is highly effective treatment of peptic ulcer disease.

A Preliminary Study for the Development of Informant-Report Scale on Cognitive-Linguistic Abilities of the Elderly: Focused on Mild Cognitive Impairment and Alzheimer’s Disease

Purpose: Subjective cognitive-linguistic test is used to supplement various objective tests and increase a diagnostic accuracy. The purpose of this preliminary study was to develop and standardize the Informant-report Scale on Cognitive-Linguistic abilities of the Elderly (ISCOLE), and investigate the correlation between ISCOLE and objective test in individuals with neurological disease. Methods: People with mild cognitive impairment (MCI) (n = 30) and Alzheimer’s disease (AD) (n = 32) completed the objective cognitive-linguistic test. Informants of these patients (n = 62) and controls (n = 35) provided ratings of ISCOLE. Results: The main findings were as follows. Firstly, there was a significant difference among three groups in all subdomains and total score of ISCOLE. Secondly, several domains like attention, higher-order cognition, and language of ISCOLE were significantly associated with the objective performances in tow groups. Thirdly, memory, language, and total score of ISCOLE were a predictor of memory in MCI group. AD’s higher-order cognition was also predicted by attention, language and higher-order cognition of ISCOLE. Conclusion: This study is expected to help confirm the overall correlations between ISCOLE and objective test, and present the predictors of objective cognitive-linguistic performances in MCI and AD. The findings have implications for the use of ISCOLE in clinical settings. We also showed evidence that the ISCOLE is an informant-based measure of cognitive-linguistic decline providing a relevant contribution to the diagnostic and prognostic investigation of patients with MCI and AD.

Study of Gastroesophageal Reflex Disease in adult Type II Diabetes Mellitus Patients with Upper Gastrointestinal Symptoms

Gastrointestinal symptoms are relatively common in clinical practice in patients with type II diabetes mellitus. type II DM has been described as possible risk factor for the development of gastroesophageal reflux disease, in this study we aim to detect the prevalence of GRED in symptomatic patients with type II DM , also to see the accuracy of reflex disease questionnaire ( RDQ) in the diagnosis of GERD in patients with type II DM in relation to the esophagogastroduodenoscopy finding and to study the relation of autonomic neuropathy to the prevalence and stages of GERD in diabetic patients . Methods: A ninety patients with upper gastrointestinal symptoms was divided in to tow groups according to whether had type II DM or not and then each group involved in a two stage process (a ) – a RDQ , ( b ) – OGD . And patients in the DM group underwent another step to detect diabetic neuropathy by a bed side clinical test. Results: The prevalence of esophagitis in this study was higher in the DM group. RDQ had a statistical significance in detecting esophagitis in the DM group. There is no relation of autonomic neuropathy to the prevalence of GERD in diabetic patients . Conclusion : The prevalence of GERD was high in patients with type II DM, RDQ is a sensitive tool for the diagnosis of GERD in diabetic pateints , Autonomic neuropathy did not increase prevalence of esophagitis in diabetic patients .

Study of Gastroesophageal Reflex Disease in Adult Type II Diabetes Mellitus patients with Upper Gastrointestinal Symptoms

Gastrointestinal symptoms are relatively common in clinical practice in patients with type II diabetes mellitus. type II DM has been described as possible risk factor for the development of gastroesophageal reflux disease, in this study we aim to detect the prevalence of GRED in symptomatic patients with type II DM , also to see the accuracy of reflex disease questionnaire ( RDQ) in the diagnosis of GERD in patients with type II DM in relation to the esophagogastroduodenoscopy finding and to study the relation of autonomic neuropathy to the prevalence and stages of GERD in diabetic patients . Methods: A ninety patients with upper gastrointestinal symptoms was divided in to tow groups according to whether had type II DM or not and then each group involved in a two stage process (a ) – a RDQ , ( b ) – OGD. And patients in the DM group underwent another step to detect diabetic neuropathy by a bed side clinical test . Results: The prevalence of esophagitis in this study was higher in the DM group. RDQ had a statistical significance in detecting esophagitis in the DM group. There is no relation of autonomic neuropathy to the prevalence of GERD in diabetic patients . . Conclusion : The prevalence of GERD was high in patients with type II DM , RDQ is a sensitive tool for the diagnosis of GERD in diabetic pateints , Autonomic neuropathy did not increase prevalence of esophagitis in diabetic patients .

Clinical study of fumigation with Shujin-Jieluan Decoction combined with Pingheng-Shujin Manipulation in the treatment of chirospasm after stroke

Objective To evaluate the efficacy of fumigation with Shujin-Jieluan Decoction combined with Pingheng-Shujin Manipulation (manipulation of balance and muscle tendon relaxing) in the treatment of chirospasm after stroke. Methods A total of 104 patients with chirospasm after stroke who metthe inclusion criteria from July 2016 to June 2018 were selectedand divided into tow groups with the digital table methodwith 52 cases in each group. The control group was given routine rehabilitation training while the observation group was given fumigation with Shujin-Jieluan decoction combined with Pingheng-Shujin manipulation based oncontrol group, and the two groups both were treated for 8 weeks. The Modified Ashworth Scale (MAS) was used for chirospasm classification, and Key Point tabletop electromyography device was used to record the frequency, average amplitude and the shortest latency of F wave of median nerve. Fugl-Meyer motor function rating scale was used to evaluate hand motor function, and modified Barthel Index (BI) was used to evaluate life functionand clinical efficacy. Results The effective rate was 88.5% (46/52) in observation group and was 65.4% (34/52) in control group (χ2=7.800, P=0.005). After treatment, the frequency (15.11 ± 2.06 vs. 16.72 ± 1.95, t=4.093), average amplitude (0.52 ± 0.04 mV vs. 0.59 ± 0.05 mV, t=7.883) and the shortest latency (24.37 ± 2.85 ms vs. 25.88 ± 2.43 ms, t=2.907) of F wave in observation group were significantly lower than the control group (P<0.01). Fugl-Meyer hand function score (6.51 ± 1.45 vs. 5.09 ± 1.22, t=5.404) and BI index score (60.87 ± 5.16 vs. 56.54 ± 4.25, t=4.671) were significantly higher than the control group (P<0.01). The distribution of MAS classification in observation group was significantly lower than that of control group (Z=8.410, P=0.004). Conclusions Fumigation with Shujin-Jieluan Decoction combined with Pingheng-Shujin Manipulation can improve the neuromuscular transmission of patients with chirospasm after stroke, and facilitate the recovery of hand function and viability. Key words: Stroke; Spasm; Rehabilitation of traditional Chinese medicine; Shujin-Jieluan Decoction; Muscle tendon relaxing reduction; Steaming washing therapy

Study The Relationship Between Polymorphism of Melatonin Receptor Type 1A (MTNR1A) Gene with Some Reproductive Performance, in Local Iraqi Goats

Melatonin is the main molecule that transmits the signal of seasonal change to the neuroendocrine system in seasonal breeding species, through specific melatonin receptors, Melatonin Receptor Type 1A. In the present study, a total of 40 local Iraqi non pregnant goats were used to study the relationship betweenPolymorphism of Melatonin Receptor Type 1A (MTNR1A) gene with some reproductive performance. Animals were reared in a farm located inAl-Yusufiya/Baghdad. Animals were divided based on breading season into two groups, with 20 animals each as follows: goats which gave birth in expected breading season (January, Febreuary,and March), and goats which gave birth in unexpected breading season (October, November, and December). All goats were reared in farm in Al-Yusufiya / Baghdad. 20 goats were given birth in January, February and March, which are representingseason, the other 0 goats which were given birth out of the breeding season during October, November and December, both tow groups were used to investigate the reproductive performance in local goats in different breeding months, the number of kids (single or twins), weight and sex of kids were record. Five milliliters of blood were collected from each goats through jugular vein puncture with EDTA coated tubes, until DNA extraction. The main part of exon II of MTNR1A gene was amplified by PCR with used specific primer and then product PCR digested with BsaI restriction enzyme. Therestriction fragment length polymorphism(RFLP) analysis used BsaI restriction enzyme, the presence of the cleavage site produces two fragments, 279 and 577 bp (C allele) while the absence of this site produces only one fragment, 856 bp (A allele). Suggested the presence of three genotypes the homozygote CC for (279 bp, 577 bp), homozygote AA for (856 bp) and the heterozygote CA for (279 bp, 577 bp, 856 bp). In all the analyzed forty local goats’ genotypic frequency was 35.0% for CC genotype, 52.5% for CA genotype and 12.5 for AA genotype. The allele frequency of C and A was 61.25% and 38.75% respectively which was in Hardy–Weinberg equilibrium. The allele C have been associated with out of season breeding ability of goats and allele A associated with season breeding from the present study, no relationship between kids weights, sex and type of parturition (single or twin) with the genetic analysis model of MTNR1A gene in local Iraqi goats.

أثر القصص النبوی على القیم السلوکیة لدى أطفال الروضة فی مدینة تبوک. The Impact of the Prophets storis on the Behavioral Values of kindergarten children in thecity of Tabuk

هدفت الدراسة إلى الکشف عن أثر استخدام القصص النبوی فی القیم السلوکیة لدى أطفال الروضة فی مدینة تبوک، ولتحقیق أهداف الدراسة تم استخدام المنهج الشبه تجریبی، وبطاقة الملاحظة کأداة لجمع البیانات، حیث تکونت من محورین، وهما: (القیم السلوکیة الدینیة، القیم السلوکیة الاجتماعیة)، وبلغ عدد أفراد الدراسة (60) طفلا وطفلة من الروضة الثانیة فی قوات الأمن العام بمدینة تبوک،تم تقسیمهم عشوائیا إلى مجموعتین تجریبیة وضابطة تکونت کل مجموعة من (30) طفلاوطفلة. وللإجابة عن أسئلة الدراسة تمت معالجة البیانات إحصائیا بواسطة برنامج (SPSS) واختبار فرضیاتها، تم استخدام اختبار ت للعینات المستقلة، کما تم استخدام معادلة مربع ایتا لحساب حجم تأثیر استخدام القصص النبوی على القیم السلوکیة لدى الأطفال،وتوصلت الدراسة فی نتائجها إلى: وجود فروق ذات دلالة إحصائیة عند مستوى (0.05 =α) بین متوسطی درجات الأطفال فی المجموعتین: الضابطة والتجریبیة فی التطبیق البعدی لمقیاس القیم السلوکیة، ولصالح المجموعة التجریبیة التی خضعت للقصص النبوی. وجود فروق ذات دلالة إحصائیة عند مستوى (0.05 =α) بین متوسطی درجات الأطفال فی المجموعتین: الضابطة والتجریبیة فی التطبیق البعدی لمحور القیم السلوکیة (الدینیة، الاجتماعیة) من مقیاس القیم السلوکیة، ولصالح المجموعة التجریبیة التی خضعت للقصص النبوی. عدم وجود فروق ذات دلالة إحصائیة عند مستوى (0.05 =α) بین متوسطی درجات الأطفال بالمجموعتین: الضابطة والتجریبیة فی التطبیق البعدی لمقیاس القیم السلوکیة فی المحورین: الأول والثانی.ومن توصیات الدراسة: ضرورة تبنی معلمات ریاض الأطفال فی مدینة تبوک أسلوب القصص النبوی خلال تدریس الأطفال، وذلک بهدف تنمیة القیم السلوکیة الدینیة والاجتماعیة لدیهم. الاهتمام بعقد دورات لمعلمات ریاض الأطفال أثناء الخدمة لتدریبیهن على استخدام القصص النبوی؛ لغایات تحسین تنمیة القیم السلوکیة الدینیة والاجتماعیة لدى الأطفال. إعداد دلیل تطبیقی لمعلمات ریاض الأطفال حول کیفیة إعداد وتنفیذها لاستخدام القصص النبوی. This study aimed to investigate of the impact of using stories of the prophets on the behavioral values among kindergarten students in Tabuk City by. To achieve the purpose of study, the quasi-experimental approach was used and observal card as atool to collect data, which included on two domains (religious behavioral values and social behavioral values). The study sample consisted (60) children were chosen from the second kindergarten grade in the public security, they were randomly divided to tow groups; the experimental and control groups which included of (30) children in each group. To answer the questions, data were statistically processed, and hypotheses were verified using (SPSS). T-test and eta square were used assest of the size of the impact of using the stories of the prophets on the behavioral values. The results study indicadetd to: There were statistically significant at the level of (α= 0.05) among the means of the students scores in the two groups in the post-test of behavioral values scale in favor of the experimental group wich exposed the stories of the prophets. There were statistically significant at the level of (α= 0.05) among the means of students scores in the two groups in the post-test of behavioral values (religious and social) scale in favor of the experimental group which exposed the stories of the prophets. There were't statistically significant at the level of (0.05) among the means of students scores in the two groups in the post-test of behavioral values in the 1st and 2nd domains. The study recomended to: Kindergarten female teachers in Tabuk shall apply the stories of the prophets in order to develop the students’ religious and social behavioral values. Training courses shall be held for in-service kindergarten female teachers to train them on using the stories of the prophets in order to develop the students’ religious and social behavioral values. An applied handbook shall be prepared for kindergarten female teachers on how to plan and implement the lessons using the stories of prophets.

Trend of lung cancer in AL-Diwanyah teaching hospital (chest department)

Lung cancer is responsible for the most cancer deaths in both men and women throughout the world. Deaths from lung cancer (160,440 in 2004, according to the National&#x0D; Cancer Institute) exceed the number of deaths from four other major cancers combined (breast, colon, pancreatic and prostate).&#x0D; &#x0D; Objective:&#x0D; To assess the behavior and the approaches of lung cancer in a sample of Iraqi patients.&#x0D; &#x0D; Methods:&#x0D; This descriptive retrospective study was performed using the records of 450 patients proved to have lung cancer that had attending the chest department in ALdiwanyah teaching hospital for the period from January,1st,2003 December,31st,2018.&#x0D; &#x0D; Results:&#x0D; The results of this study revealed that 70% of the patients were male, with a mean age of 63 years. The majority of the patients (96%) were smokers, the number of cases increases with the increase in the duration of smoking or the amount of daily cigarette smoking. ,that can be calculated into tow groups(more than 20 pack-year were 80% while less than 20 pack-year were 16%).&#x0D; Conclusions:&#x0D; Lung cancer is an important and serious public health problem with an increasing in incidence and prevalence in Iraq; cough is the most common clinical finding, found in 60% of patients, followed by chest pain (22%); cigarette smoking is responsible for the at least 95% of its etiology. Sequamous cell carcinoma is the most common type of primary lung cancer in Iraq (44%) with prominence in male gender; adenocarcinoma is the second common type(30%). Key words: Lung cancer, Bronchogenic carcinoma,Tumor

PF752 AUTOLOGOUS STEM CELL TRANSPLANT CONDITIONING WITH CHIDAMIDE, CLADRIBINE, GEMCITABINE AND BUSULFAN AS CONSOLIDATION MAY OVERCOME POOR PROGNOSIS OF PATIENTS WITH DOUBLE EXPRESSER LYMPHOMA

Background:Double‐protein‐expression lymphomas (DEL) is a unique sub‐group of diffuse large B‐cell lymphoma (DLBCL) with co‐expression of MYC and BCL‐2 on immunohistochemistry. Compared with classic DLBCL, DEL has a lower response to standard induction chemoimmunotherapy with rituximab added to cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) and poorer prognosis. Autologous stem cell transplant (ASCT) is a potentially curative treatment of high‐risk of relapsed/refractory lymphomas. However, the role of ASCT in patients with DEL is controversy. Our pre‐clinic and clinic studies showed the combination of chidamide, cladribine, gemcitabine and busulfan (ChiCGB) worked synergistically against lymphomas.Aims:So, in this study, we used ASCT conditioning with ChiCGB as consolidation in patients with DEL in first or second complete remission.Methods:This study was a phase 2 trial done at the West China Hospital of Sichuan University from May. 2016 to Dec. 2018. Eligible patients were aged 16–65 years and had received R‐CHOP or chidamide‐R‐CHOP as first‐line or any second‐line therapies. They achieve first or second complete remission (CR) before transplant. The DEL was diagnosed as MYC expression ≥ 40% and BCL‐2 ≥ 50% on immunohistochemistry. Additional eligibility criteria were an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2, adequate major organs function, no active hepatitis bacteria, fungal or virus infection. Patients provided written informed consent to participate in the trial. Patients with DLBCL without MYC and BCL‐2 over‐expression were assigned to the control group (non‐DEL).Patients received ChiCGB conditioning regimen consisting of oral chidamide 30 mg on days −7, −4, 0, +3, intravenous cladribine at a dose of 6 mg/m2 from days −6 to −2, intravenous gemcitabine 4 hours after cladribine at a dose of 2500 mg/m2 on days −6 and −2, and intravenous busulfan at a fixed dose of 3.2 mg/kg from days −6 to −2. Dexamethasone was prophylactically given for adverse effect of high dose gemcitabine from the day −6 to −2. Peripheral‐blood stem‐cells were infused on day 0.Results:A total of 44 patients with DLBCL were enrolled, with 22 DEL and 22 non‐DEL. The median age was 46 (range, 23 to 61) and 34.5 (range, 16 to 61) years in DEL and non‐DEL groups. There were 8 (36.3%) and 12 (54.5%) patients in second CR in DEL and non‐DEL group respectively. In DEL group, 5 patients receive chidamide‐R‐CHOP as first‐line therapy. Stem cells source was peripheral blood. Median infused CD34+cells count was 2.2 × 106/Kg (range, 1.0 to 11.6 × 106/Kg). Neutrophils and platelets were engrafted on a median day +10 (+8 to +14) and day +12 (range, days +8 to +38), respectively. The median follow‐up was 17.8 (range, 4.1 to 34.9) and 20 (range, 3 to 46.3) months in DEL and non‐DEL group. The 2‐year progression free survival of patients with DEL or non‐DEL was 94.4% and 84.2% (P = 0.3731), while the 2‐year overall survival of tow groups was 94.1% and 100% (P = 0.2904) (Figure‐1).Summary/Conclusion:Our study showed ChiCGB efficiently prevented relapse of DEL. Compared with the survival of patients with non‐DEL, ChiCGB with ASCT may overcome poor prognosis of patients with diffuse large B‐cell lymphoma with co‐expression of MYC and BCL‐2.image

Case-control study on long head of biceps tendon cut-off and re-fixation for the treatment of proximal humeral fractures

To investigate clinical effect of open reduction and internal fixation in treating proximal humeral fracture by using long head of biceps tendon cutted-off and re-fixation. From January 2014 to January 2017, 50 patients with proximal humeral fractures were treated by open reduction and internal fixation. According to whether long head of biceps tendon cutted-off and re-fixation, patients were divided into control group and treatment group, 25 patients in each group. There were 13 males and 12 females with an average of (73.8±4.5) years old in control group, treated with conventional open reduction and internal fixation. There were 15 males and 10 females, with an average of (74.1±5.4) years old in treatment group, treated by using long head of biceps tendon cutted-off and re-fixation on the basis of control group. Fracture healing time and complications after operation were compared between two groups, VAS score was used to evaluate relieve degree of pain, and Neer functional score at 1, 3, 6, 12 months after operation was applied to access clinical efficacy. All patients were followed up for 12 to 24 months with an average of (14.5±3.6) months. There was no statistical difference in following-up between tow groups. Postoperative VAS score at 1 week between treatment group and control group were 2.92±1.10 and 5.88±0.90 respectively, and had significant difference(P<0.05). Postoperative Neer functional scores at 1 month between treatment group and control group were 77.88±5.70 and 73.68±4.90 respectively, while 85.88±5.30 and 79.88±3.90 respectively at 3 months after operation, and there were significant difference between two groups at 1 and 3 months after operation(P<0.05). There were no statistical differences in Neer functional score between two groups at 6 and 12 months after operation(P>0.05). According to postoperative Neer score at 12 months, 9 patients got excellent results, 14 moderate and 2 poor in treatment group; while 4 patients got excellent results, 18 moderate and 3 poor in control group; but there was no difference between two groups. Fracture were healed without postoperative complications between two groups. Open reduction internal fixation with in treating proximal humeral fracture by using long head of biceps tendon cutted-off and re-fixation could reduce pain, speed up early recovery of joint function, is worthy of further promotion.

Effect of successive cyclic oral contraceptive pills on pregnancy outcome pretreatment of PCOS patient in ICSI

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that primarily affects women of reproductive age, with prevalence rates ranging from 5% to 10%. Objective: To evaluate the role of oral contraceptive pills (OCP) pretreatment in the improvement of intra cytoplasmic sperm injection (ICSI) pregnancy outcome, in patient with PCOS. Methodology:Started with 200 proved PCOS and after exclude of any patient with criteria rather than including criteria, so 60 proved PCOS women undergo ICSI were elected and divided into tow groups 30 patients for each. The 1st group treated with COC (3-6monthes) before ICSI and the 2nd group was a control group. Results: Clinical pregnancy rate as a main outcome was significantly more frequent in the study group than in the control group. The LH mean as a secondary outcome was significantly more decreased in the study group than in the control group and the FSH/LH ratio before and after COC increasing ratio towards normalization. Conclusion: Successive cyclic oral contraceptive pills for patients with PCOS as a pretreatment in ICSI can increase clinical pregnancy rates as a main outcome, improve the synchronism of follicular development, decrease the LH mean as a secondary outcome. And increase FSH/LH ratio before and after COC towards normalization.

A critical study on the Safavids historians works about Mirnajm's II Campaign in Transoxiana

After the defeat of the Shibak-khan Uzbek in Merv in 916 A.H., the second important event in the Transoxiana region was the Mirnajm's II Campaign that resulted in his sever defeat. So, this Campaign is very important for study, because the real motive and aims of the Campaign reflected with the differences and the contradictions in the Safavids historians works. Hence, the main question is that : What were the motive and the aims of this Campaign, in the eyes of the Safavids historians ? In this direction, these historians are divided- according to their writings- in tow groups: The first group of historians believe that the aims of this Campaign was the suppression of the Mohammad-Baber who-according to them-was planning to rebel. But, the second group- without any refer to Baber's rebellion- believes that the aims of this Campaign was the suppression of the Uzbeks that endangered the Eastern region of Iran. So, this research show that the view of the second group is closer to the aims of this Campaign : the suppression of the Uzbeks.

A12457 The Characteristic of central blood pressure and arterial stiffness in hypertensive female with different menopause period

Objectives: The aim of this study is to make sure the characteristic of central blood pressure and arterial stiffness in female hypertension with different menopause period. Methods: One hundred and eighteen subjects of essential hypertension were selected from Lanzhou University Second Hospital during November 2014 to November 2015. All female patients divided into two groups by the duration of menopause,one was short-term group (duration of menopause ≤5 Years).And at same time,the male patients whose age similar to female were selected as the short duration controls group.Another female hypertensive patients was long-term menopausegroup (duration of menopause 5 > years),equally,the male patients of similar age were also selected as the long-term control subjects.Sex hormone of female,SBP,DBP,PP were measured. cSBP,cDBP,CPP,AP,AIx,AIx75HR,carotid-femoral pulse wave velocity (cf-PWV) were detected. Results: In short-term control group,SBP,DBP,HR,cSBP,cf-PWV were higher than short-term menopause group,but the parameters of PP,AP,CPP,AIx and AIx75HR were higher in short-term group.The difference of SBP,DBP,cDBP,AIx75HR between tow groups a were significant (P < 0.05)).However,in long-term menopause group,the parameter of SBP,DBP,PP,HR,cSBP,CPP,AP,AIx,AIx75HR and cf-PWV were higher than those of in long-term control group,and the differences of SBP,PP,cDBP, CPP,AP,AIx75HR were significant (P < 0.05).For the short-tern groups,the estrogen of estradial (eE2) and progesterone (PGRE) were higher than long-term groups,and the difference of eE2 is significant (P < 0.05). Conclusion: For the short-term menopause females the protective effect of estrogen were existed,this effect is not only protect the peripheral brachial blood pressure but also the central blood pressure.But the effect of estrogen on arterial stiffness were not clearly.