Abstract. Here we research the multivariate quantitative approximation of Banach space valued continuous multivariate functions on a box or RN, N ∈ N, by the multivariate normalized, quasi-interpolation, Kantorovich type and quadrature type neural network operators. We investigate also the case of approximation by iterated multilayer neural network operators of the last four types. These approximations are achieved by establishing multidimensional Jackson type inequalities involving the multivariate modulus of continuity of the engaged function or its partial derivatives. Our multivariate operators are defined by using a multidimensional density function induced by a q-deformed and λ-parametrized A-generalized logistic function, which is a sigmoid function. The approximations are pointwise and uniform. The related feed-forward neural network are with one or multi hidden layers. Mathematics Subject Classification (2010): 41A17, 41A25, 41A30, 41A36. Keywords: Multi-layer approximation, q-deformed and λ-parametrized A- generalized logistic function, multivariate neural network approximation, quasi-interpolation operator, Kantorovich type operator, quadrature type operator, multivariate modulus of continuity, iterated approximation.