This study is devoted to test the structural response of reinforced concrete horizontally curved box beams in presence of vertical and transverse opening restored by CFRP Laminates or Reactive Powder Concrete (RPC) technique and compared to that having opening but without restoring. Six horizontally circular curved box beams were casted and tested in this experimental work, three specimens with opening in vertical direction and the other three specimens including opening in transverse direction. Accordingly, each direction has three types of beams, first one including opening without restoring and used as a reference specimen, second one with opening restored by CFRP Laminates technique and third one with opening restored by Reactive Powder Concrete (RPC) technique. The test program includes the main variables; direction of opening. The beams were tested as a two-span continuous beam, each span represents a quarter circle, under the effect of two concentrated loads each load positioned at top face of midspan of the beam. The findings of the experiments showed that the use of Reactive Powder Concrete (RPC) and CFRP Laminates and techniques around opening notably increased the ultimate load capacity of specimens (CB2.V60.S1, CB3.V60.S2, CB5.T60.S1 and CB6.T60.S2) by about (18.5% and 15.3%,135% and 38.3%) respectively, when compared with specimens without restoring. Service mid-span deflection response not give clear effect, while service mid-span twisting was improved by about (55.28%, 13%, 10.73% and 2.37%) for all restored specimens (CB2.V60.S1, CB3.V60.S2, CB5.T60.S1 and CB6.T60.S2) respectively. Genially, significant increase in stiffness can be observed for restored specimens as a comparison with those without restoring.