A high-performance thin-layer chromatographic method was developed and validated for simultaneous determination of phenylephrine hydrochloride and ketorolac tromethamine in combined dose formulation. The chromatography was performed on pre-coated silica gel 60 F 254 plates using n-Butanol: Ethanol: Ammonia (6:3.5:0.6, v/v/v) as mobile phase. The plates were developed to a distance of 8.0 cm at ambient temperature. A TLC scanner set at 288 nm was used for direct evaluation of the chromatograms in reflectance/absorbance mode. The drugs were satisfactorily resolved with RF 0.30 for phenylephrine hydrochloride and 0.67 for ketorolac tromethamine. Method was validated according to the ICH guidelines. The calibration plot was linear between 1026-6156 ng per band for PHE and 300-1800 ng per band for KETO. The LOD and LOQ for PHE were 89.36 and 295.5 ng per band, for KETO they were 136.46 and 73.74 ng per band, respectively. Accuracy and precision of the proposed method was evaluated by recovery studies and intra-day and inter-day precision studies respectively. In stability testing, PHE and KETO were found susceptible to acid hydrolysis and alkaline degradation. Because the method could effectively separate the drugs from their degradation products, it may be used as a stability indicating method.