The current research work is intensively focused on zinc phosphate doped Poly(3,4-ethylenedioxythiophene PEDOT electropolymerized on titania nanotube arrays (TNTA) that fabricated on Cp-Titanum by anodic oxidation process for orthopaedic application. The preliminary characterization studies were conducted to determine the morphology, elemental composition, phase transformation and functional group of the ZnP-PEDOT/TNTA. Moreover, the wettability of the material was tested using water contact angle. The promising corrosion resistance of electropolymerized hybrid material was evaluated from electrochemical impedance spectroscopy and polarization studies. The bioactivity and in vitro biocompatibility were determined by biomineralization studies, where the material was immersed in Hanks’ solution for 21 days. Similarly, (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) MTT assay with MG63 cells was carried out to understand the cell viability and proliferation of the material with the presence of zinc phosphate along with PEDOT. The contribution against the antibacterial performance of zinc phosphate and PEDOT on TNTA implant material was tested using gram-positive and gram-negative bacteria. Overall the obtained outcomes exhibited outstanding biocompatibility, excellent anticorrosion and antibacterial properties. Hence ZnP-PEDOT/TNTA together makes a promising potential hybrid material for bone performance in the orthopaedic field.