Especially for electric vehicles, the tire impact on car noise is becoming more and more important. The requirement of meeting certification criteria makes estimating the sound pressure level essential for vehicle manufacturers. Most recent research on tire road noise is conducted on component test benches. Little research exists into tires mounted on vehicles, and even less into the impact of acceleration on the generated noise. The literature mainly considers some vehicle shape differences, tire load, and inflation pressure. This article investigates the impact of different vehicles on tire noise through a series of measurements on a standardized test track. The rolling noise as well as accelerated noise of three different tires and five different vehicles are compared. The impact of the drive axle on accelerated noise as well as a weight variation is investigated. Additionally to the absolute measured differences between the vehicles, statistical methods are used to separate measurement dispersion from actual systematic differences. This research therefore validates older research on the vehicles’ impact on tire noise, which is necessary since the general tire structure, thread, and rubber composition have changed in the time period between the publication of previous research from the literature and this paper. This allows us to approximate the emitted noise on different vehicles. Furthermore, we validate an algorithm to virtually change tires on test benches. The algorithm is standardized and implemented in common measurement software.