Ti–6Al–4V, an alloy of titanium has recently gained focus of research to overcome its machinability challenges. Miniaturization in devices has forced a shift towards micro and meso-scale machining. Sustainability and green manufacturing concepts have shifted focus in machining from cutting fluids towards modern cooling approaches to minimize or eliminate them. In present research, cutting forces & tool wear in Ultrasonic Vibrations Assisted End Milling of Ti–6Al–4V at meso-scale under Dry, Flooded, Minimum Quantity Lubrication & Cryogenic cooling have been analyzed to develop optimum machining parameters. Taguchi L16 orthogonal array was designed to perform experiments keeping Cutting Speed, Feed per tooth, Depth of cut, Ultrasonic vibrations amplitude & Cooling environment as inputs. ANOVA was used to analyze contribution ratios by these parameters towards cutting forces & tool wear. Results indicated that machining conditions, cooling environment and Ultrasonic Vibrations influence cutting forces & tool wear. Depth of cut had the highest influence with 63.41% contribution towards cutting forces while cutting speed remained the highest influencing factor with 39.86% contribution towards tool wear. Cutting forces were reduced by 33.49%, 16.93% and 4.91% while tool wear was reduced by 26.43%, 9.48% and 5.17% under Minimum Quantity Lubrication environment compared to dry, flooded and cryogenic cooling respectively. Cutting forces and tool wear under ultrasonic vibrations were reduced by 24.52% and 13.16% respectively as compared to Conventional Machining (CM). For optimum results, Minimum Quantity Lubrication with low Cutting Speed, Depth of cut, Feed per tooth and high amplitude of ultrasonic vibrations is recommended to machine Ti–6Al–4V.