The total cross sections for the Sn 116 ( p , γ ) Sb 117 , Sn 114 ( p , γ ) Sb 115 , Zn 64 ( p , γ ) Ga 65 , and Ti 46 ( p , γ ) V 47 reactions have been measured using an activation technique for protons with center-of-mass energies between about 1 and 4 MeV. Radiative proton captures on 116Sn and 64Zn are compared to previous measurements while extending the measured energy range of the cross sections. From these measurements, astrophysical S-factors have been deduced by integrating NON-SMOKER results which have been scaled to the deduced S-factors in the measured energy range. Comparisons are made to thermonuclear reaction rates from the MOST and NON-SMOKER statistical model calculations. The accuracies of these codes are discussed in light of possible structure differences of the nuclei in question.