Theory Of Mind Processing Research Articles

Dynamic functional connectivity in the right temporoparietal junction captures variations in male autistic trait expression.

Autistic individuals can experience difficulties with attention reorienting and Theory of Mind (ToM), which are closely associated with anterior and posterior subdivisions of the right temporoparietal junction. While the link between these processes remains unclear, it is likely subserved by a dynamic crosstalk between these two subdivisions. We, therefore, examined the dynamic functional connectivity (dFC) between the anterior and posterior temporoparietal junction, as a biological marker of attention and ToM, to test its contribution to the manifestation of autistic trait expression in Autism Spectrum Condition (ASC). Two studies were conducted, exploratory (14 ASC, 15 TD) and replication (29 ASC, 29 TD), using resting-state fMRI data and the Social Responsiveness Scale (SRS) from the Autism Brain Imaging Data Exchange repository. Dynamic Independent Component Analysis was performed in both datasets using the CONN toolbox. An additional sliding-window analysis was performed in the replication study to explore different connectivity states (from highly negatively to highly positively correlated). Dynamic FC was reduced in ASC compared to TD adults in both the exploratory and replication datasets and was associated with increased SRS scores (especially in ASC). Regression analyses revealed that decreased SRS autistic expression was predicted by engagement of highly negatively correlated states, while engagement of highly positively correlated states predicted increased expression. These findings provided consistent evidence that the difficulties observed in ASC are associated with altered patterns of dFC between brain regions subserving attention reorienting and ToM processes and may serve as a biomarker of autistic trait expression.

Patterns of executive functions and theory of mind in adults with a family history of alcohol use disorder: Combined group and single-case analyses.

Impairments in executive function and social cognition are highly prevalent in individuals with an alcohol use disorder (AUD). Some studies show that similar difficulties are displayed by individuals with a positive family history of AUD (FH+) compared with individuals with a negative family history (FH-). Yet, no studies have jointly investigated cognitive and affective theory of mind at the behavioral level. Moreover, some studies show preserved executive and socioemotional functioning in FH+ participants. One possible explanation for these divergent results is that FH+ individuals are cognitively heterogeneous. In this study, we examined the frequency and co-occurrence of difficulties in executive function and social cognition among FH+ individuals at the individual level. Sixty FH+ and 60 FH- participants matched on age, sex, and education level were included. They completed tasks assessing executive functions (Stroop, Trail Making Test) and affective and cognitive theory of mind (Movie for the Assessment of Social Cognition). They also completed self-report questionnaires measuring impulsivity, alexithymia, and empathy. Single-case analyses assessed the proportion of FH+ participants with difficulties in executive function and/or theory of mind. FH+ individuals exhibited difficulties in response inhibition and made more errors during theory of mind processing, indicating an absence of mental state representation, compared with FH- individuals. In the FH+ sample, 53.33% had executive function and/or theory of mind difficulties. Those with lower theory of mind scores reported higher alexithymia and lower empathy on self-report measures. FH+ individuals display heterogeneous executive function and theory of mind abilities. Given that they mostly occur independently of one another, executive function and theory of mind difficulties may be distinct vulnerability markers in AUD.

B - 70 Left-Sided Motor Symptoms in Parkinson's Disease Are Associated with Impaired Social Cognition: a Preliminary Study.

Disruption of frontostriatal pathways underlies working memory and executive function impairments in Parkinson's disease (PD), including theory of mind (ToM). PD symptoms appear on one side and remain lateralized, suggesting greater dysfunction in the contralateral basal ganglia. Previous studies have suggested the right hemisphere, particularly right frontal lobe, has greater involvement in ToM processing. We hypothesized PD subjects with left hemi-motor symptoms, indicating right hemisphere involvement, would show greater deficits on a ToM task. Fourteen PD subjects with lateralized symptoms (9 left, 5 right) and 12 controls were selected from an ongoing NIH-funded study. Participants were right-handed and free of other neurological conditions. Groups did not differ on age, education or sex. Participants completed a ToM story task, neuropsychological measures (Visual-Verbal test, verbal and design fluency, and digit span) and a depression scale. Relative to controls, PD subjects with left-sided symptoms had trouble deciding if the character was lying or joking (p = 0.001 95% CI[1.002, 4.277]) and trending difficulty discerning a character's second order belief (what another character was thinking) when the intent was humorous (p = 0.077; 95% CI[-0.122, 3.055]), after accounting for age. ToM story performance correlated with cognitive measures in PD subjects with right-sided symptoms, but not in those with left-sided symptoms or controls. Individuals with PD and demonstrating left hemi-motor symptoms may have greater difficulty in social cognition beyond executive function or working memory disorders, impacting interactions with caregivers and their quality of life. Investigation with a larger sample is needed to confirm these findings.

Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder.

Social cognition impairments are a common feature of alcohol use disorders (AUD). However, it remains unclear whether these impairments are solely the consequence of chronic alcohol consumption or whether they could be a marker of vulnerability. The present study implemented a family history approach to address this question for a key process of social cognition: theory of mind (ToM). Thirty healthy adults with a family history of AUD (FH+) and 30 healthy adults with a negative family history of AUD (FH-), matched for age, sex, and education level, underwent an fMRI cartoon-vignette paradigm assessing cognitive and affective ToM. Participants also completed questionnaires evaluating anxiety, depressive symptoms, childhood trauma, and alexithymia. Results indicated that FH+ individuals differed from FH- individuals on affective but not cognitive ToM processing, at both the behavioral and neural levels. At the behavioral level, the FH+ group had lower response accuracy for affective ToM compared with the FH- group. At the neural level, the FH+ group had higher brain activations in the left insula and inferior frontal cortex during affective ToM processing. These activations remained significant when controlling for depressive symptoms, anxiety, and childhood trauma. These findings highlight difficulties during affective ToM processing among first-degree relatives of AUD patients, supporting the idea that some of the impairments exhibited by these patients may already be present before the onset of AUD and may be considered a marker of vulnerability.

Gaze patterns and brain activations in humans and marmosets in the Frith-Happé theory-of-mind animation task.

Theory of Mind (ToM) refers to the cognitive ability to attribute mental states to other individuals. This ability extends even to the attribution of mental states to animations featuring simple geometric shapes, such as the Frith-Happé animations in which two triangles move either purposelessly (Random condition), exhibit purely physical movement (Goal-directed condition), or move as if one triangle is reacting to the other triangle's mental states (ToM condition). While this capacity in humans has been thoroughly established, research on nonhuman primates has yielded inconsistent results. This study explored how marmosets (Callithrix jacchus), a highly social primate species, process Frith-Happé animations by examining gaze patterns and brain activations of marmosets and humans as they observed these animations. We revealed that both marmosets and humans exhibited longer fixations on one of the triangles in ToM animations, compared to other conditions. However, we did not observe the same pattern of longer overall fixation duration on the ToM animations in marmosets as identified in humans. Furthermore, our findings reveal that both species activated extensive and comparable brain networks when viewing ToM versus Random animations, suggesting that marmosets differentiate between these scenarios similarly to humans. While marmosets did not mimic human overall fixation patterns, their gaze behavior and neural activations indicate a distinction between ToM and non-ToM scenarios. This study expands our understanding of nonhuman primate cognitive abilities, shedding light on potential similarities and differences in ToM processing between marmosets and humans.

Thinking about Past Minds: Cognitive Science as Philosophy of Historiography

Abstract This paper outlines the case for a future research program that uses the tools of experimental cognitive science to investigate questions that traditionally fall under the remit of the philosophy of historiography. The central idea is this – the epistemic profile of historians’ representations of the past is largely an empirical matter, determined in no small part by the cognitive processes that produce these representations. However, as the philosophy of historiography is not presently equipped to investigate such cognitive questions, legitimate concerns about evidential quality go largely overlooked. The case of mental state representation provides an excellent illustration of this. Representations of past mental states – the thoughts and fears and knowledge and desires of past agents – play much the same evidential role in historiography as in everyday life, serving in the causal explanation of agents’ behaviors and supporting normative evaluation of those behaviors. However, we have good reason to suspect that the theory of mind processes that support these representations may be more susceptible to error when deployed in the context of historiography than under everyday conditions. This raises worries about the quality of evidence that theory of mind can provide historiography, worries which require experimental cognitive science to properly address.

Theory of Mind and Reactions to Emotional Responses in Children with Visual Impairments: A Comparison with Sighted Children

Introduction: Theory of Mind (ToM) is a social cognitive process that provides the basis for positive social responses in personal interactions. Possessing ToM makes it possible to recognize and understand other people’s thoughts, beliefs, and emotions. Due to the relationship between ToM and understanding emotions, the purpose of this study was to compare the reactions to emotional responses (happy and sad) of children with low vision, children with severe visual impairments, and sighted children with the ToM processes. The research's purpose was to investigate the relationships between the children's ToM scores and their responses to emotional expressionsMethod: The study consisted of 20 children with low vision (x = 58.45, sd = 1.74), 19 children with severe visual impairments (x = 60.36, sd = 1.84), and 20 sighted children (x̄ = 60.35, ss = 1.58) who were between the ages of 48 and 72 months and did not have additional disabilities or developmental delays. Participants were initially assessed with the ToM, First Order False Belief, Unexpected Location, and Unexpected Content tasks. In the second stage, the researcher played with each child for about 20 minutes to assess the participants' reactions to emotional responses. The researchers created emotional social scenarios implemented within a play dyad through which the researcher would display happy and sad feelings. Children’s reactions to emotional responses were coded and analyzed.Findings: The study findings showed that children with severe visual impairments received lower scores on the ToM tasks than children with low vision and sighted children. Additionally, results indicated that children with low vision and severe visual impairments displayed increased ignorance toward the researcher’s emotional expressions compared to sighted children. The current study found that children with severe visual impairments and sighted children’s ToM scores were related to their reactions to emotional responses.Discussion: Findings from the current study suggest that children with severe visual impairments may display emotional reaction difficulties while participating in various emotional and social situations. Based on the study results, suggestions for future research and early intervention practices were provided.

Does the right temporo-parietal junction play a role in processing indirect speech acts? A transcranial magnetic stimulation study

In communication, much information is conveyed not explicitly but rather covertly, based on shared assumptions and common knowledge. For instance, when asked “Did you bring your cat to the vet?” a person could reply “It got hurt jumping down the table”, thereby implicating that, indeed, the cat was brought to the vet. The assumption that getting hurt jumping down a table motivates a vet visit is tacitly attributed to the speaker by the listener, which implies Theory of Mind (ToM) processes. In the present study, we apply repetitive transcranial magnetic stimulation to the right temporo-parietal junction (rTPJ), a key brain region underlying ToM, with the aim to disrupt ToM processes necessary for language understanding. We then assess effects on the comprehension of indirect speech acts and their matched direct controls. In one set of conditions, the direct and indirect stimuli where not matched for speech act type, whereas, in the other, these were matched, therefore providing an unconfounded test case for in/directness. When indirect speech acts and direct controls were matched for speech act type (both statements), the indirect ones took longer to process both following sham and verum TMS. However, when the indirect and direct speech acts were not matched for communicative function (accept/decline offer vs. descriptive statement respectively), then a delay was detected for the indirect ones following sham TMS but, crucially, not following verum TMS. Additionally, TMS affected behavior in a ToM task. We therefore do not find evidence that the rTPJ is causally involved in comprehending of indirectness per se, but conclude that it could be involved instead in the processing of specific social communicative activity of rejecting of accepting offers, or to a combination of differing in/directness and communicative function. Our findings are consistent with the view that ToM processing in rTPJ is more important and/or more pronounced for offer acceptance/rejection than for descriptive answers.

Examining whether adults with autism spectrum disorder encounter multiple problems in theory of mind: a study based on meta-analysis.

Theory of mind (ToM) represents a complex ability, while persons with autism spectrum disorder (ASD) encounter difficulties in the processing of ToM. The present ToM-focused studies on adults with ASD report inconsistent results, possibly owing to the differences between tasks. For instance, different ToM-related tasks involve different cognitive abilities, but the development of these cognitive abilities is different among adults with ASD, thereby leading to different behaviors by the same individual with ASD in different tasks. Therefore, it is of vital significance to explore the potential reasons for inconsistencies in the existing studies based on the task classification perspective. Hence, this study primarily reviews the existing ToM tasks used in studies on adults with ASD; afterward, based on the forms and characteristics of the task, the current ToM tasks are classified into four categories-reading comprehension, perceptual scene comprehension, comprehensive scene comprehension , and self-other processing. Subsequently, a meta-analysis is undertaken to determine the difference in each ToM task category between the ASD group and the typically developing (TD) group. As a result, 110 research papers (including 3,205 adults with ASD and 3,675 TD adults) that fulfilled the stated criteria are examined in this study. The study findings suggest that adults with ASD demonstrate worse performance in terms of all four ToM task categories as compared to TD adults. Furthermore, compared with tasks of self-other processing and perceptual scene comprehension, adults with ASD perform worse in reading comprehension and comprehensive scene comprehension. This shows that the differences between tasks may exert a potential influence on the study results. Future studies should focus on different abilities involved in ToM processing and the choice of ToM tasks, in order to elucidate the critical problems of ToM in adults with ASD.

Increased Functional Connectivity Involving the Parahippocampal Gyrus in Patients with Schizophrenia during Theory of Mind Processing: A Psychophysiological Interaction Study

Theory of Mind (ToM) is an ability to infer the mental state of others, which plays an important role during social events. Previous studies have shown that ToM deficits exist frequently in schizophrenia, which may result from abnormal activity in brain regions related to sociality. However, the interactions between brain regions during ToM processing in schizophrenia are still unclear. Therefore, in this study, we investigated functional connectivity during ToM processing in patients with schizophrenia, using functional magnetic resonance imaging (fMRI). A total of 36 patients with schizophrenia and 33 healthy controls were recruited to complete a ToM task from the Human Connectome Project (HCP) during fMRI scanning. Psychophysiological interaction (PPI) analysis was applied to explore functional connectivity. Patients with schizophrenia were less accurate than healthy controls in judging social stimuli from non-social stimuli (Z = 2.31, p = 0.021), and displayed increased activity in the right inferior frontal gyrus and increased functional connectivity between the bilateral middle temporal gyrus and the ipsilateral parahippocampal gyrus during ToM processing (AlphaSim corrected p < 0.05). Here, we showed that the brain regions related to sociality interact more with the parahippocampal gyrus in patients with schizophrenia during ToM processing, which may reflect a possible compensatory pathway of ToM deficits in schizophrenia. Our study provides a new idea for ToM deficits in schizophrenia, which could be helpful to better understand social cognition of schizophrenia.

Association of cognitive flexibility with neural activation during the theory of mind processing

Theory of mind (ToM), which is the ability to infer and reason about others’ mental states, plays a key role in successful social interactions. Previous studies have shown that cognitive flexibility (CF), which refers to the ability to adequately switch between different perspectives, is linked to ToM performance in a variety of experimental tasks. However, the mechanisms of the association between CF and ToM is still largely unknown. Here, we investigated the relation of CF with neural activity during ToM processing in 26 healthy male adults using a functional magnetic resonance imaging task of moving shapes in social patterns. The CF abilities were estimated using the self-report Cognitive Flexibility Scale. Diverse brain areas, including the middle frontal gyrus (MFG), inferior frontal gyrus, amygdala, precuneus, and temporoparietal junction (TPJ), were activated during ToM processing. In these areas, individual differences in CF abilities were associated with the strength of neural activity in the right MFG and TPJ. These findings highlight the notion that cognitive ability to switch between different perspectives according to a changing environment is crucial for the attribution of mental state to others, and suggest that the right MFG and TPJ are deserving of further examination for the development of new therapies to improve social cognition in clinical populations.

The influence of in-groups and out-groups on the theory-of-mind processing: evidence from different ethnic college students

According to previous studies of theory of mind (ToM), social environment and cultural background affect individuals’ cognitive ability to understand other people’s minds. There are cross-group differences in ToM. The present study aimed to examine whether social environment and culture affect the ToM in Uygur and Han groups and whether the individual’s cognitive ToM and affective ToM show in-group advantages. Han and Uygur college students were recruited as participants. The “self/other differentiation task” was used to measure cognitive ToM (Study 1), and the “Yoni task” was used to measure both cognitive and affective ToM (Study 2). We found that Han participants processed the cognitive and affective states of others faster and more accurately than Uygur ones. Uygur and Han participants processed in-group members’ cognitive and affective states faster and more accurately. Furthermore, Uygur participants were more accurate in the cognitive ToM processing of in-group members, while Han participants were faster in the affective ToM processing of in-group members. The findings indicated that ethnic culture and group identify might influence ToM processing. Strengthening exchanges between ethnic groups may enable individuals to better process out-group members’ psychological states.

The impact of executive dysfunctions on Theory of Mind abilities in Parkinson's disease

Theory of Mind (ToM) is the ability to infer and reason about others' mental states, a process impaired by Parkinson's disease (PD). ToM performance in PD seems to be strongly related to executive functioning but the exact nature of this relationship is still unclear. We aim to investigate the direct impact of several executive dysfunctions on ToM deficits (Affective and Cognitive ToM) in PD patients.Sixty-eight PD patients underwent neuropsychological tests evaluating executive control such as inhibition, cognitive flexibility, processing speed or working memory and Cognitive and Affective ToM. We divided participants into two groups based on their performance on executive tests: PD patients with poor executive functioning (PD-EF-) and those with preserved executive functioning (PD-EF+). To explore the direct impact of executive subdomains on ToM abilities, two mediation models were executed in the whole sample.We found that PD patients with poor executive functioning reported poorer scores on Affective and Cognitive ToM tasks than PD patients with preserved executive functions, controlling for age and education. Moreover, parallel mediation models, conducted in the whole sample, indicated that performance on phonological fluency mediated the relationships between educational level and both Affective and Cognitive ToM, controlling the effect of other executive tests.These findings further support the idea that executive functions are crucial in ToM processes. Particularly, phonological fluency, whose execution requires both verbal abilities and cognitive flexibility, mediated ToM performance controlling the effect of other executive functions. The identification of neuropsychological processes underpinning ToM abilities might represent a plausible target for cognitive training to strengthen ToM abilities in PD.

Characterising the spatial and oscillatory unfolding of Theory of Mind in adults using fMRI and MEG.

Theory of Mind (ToM) is a core social cognitive skill that refers to the ability to attribute mental states to others. ToM involves understanding that others have beliefs, thoughts and desires that may be different from one's own and from reality. ToM is crucial to predict behaviour and navigate social interactions. This study employed the complementary methodological advantages of both functional MRI (fMRI) and magnetoencephalography (MEG) to examine the neural underpinnings of ToM in adults. Twenty healthy adults were first recruited to rate and describe 28 videos (15s long), each containing three moving shapes designed to depict either social interactions or random motion (control condition). The first sample of adults produced consistent narratives for 6 of those social videos and of those, 4 social videos and 4 control videos were chosen to include in the neuroimaging study. Another sample of twenty-five adults were then recruited to complete the neuroimaging in MEG and fMRI. In fMRI, we found increased activation in frontal-parietal regions in the social compared to the control condition corroborating previous fMRI findings. In MEG, we found recruitment of ToM networks in the social condition in theta, beta and gamma bands. The right supramarginal and angular gyri (right temporal parietal junction), right inferior parietal lobe and right temporal pole were recruited in the first 5s of the videos. Frontal regions such as the superior frontal gyrus were recruited in the second time window (5–10s). Brain regions such as the bilateral amygdalae were also recruited (5–10s), indicating that various social processes were integrated in understanding the social videos. Our study is one of the first to combine multi-modal neuroimaging to examine the neural networks underlying social cognitive processes, combining the strengths of the spatial resolution of fMRI and temporal resolution of MEG. Understanding this information from both modalities helped delineate the mechanism by which ToM processing unfolds over time in healthy adults. This allows us to determine a benchmark against which clinical populations can be compared.

Evidence of the role of the cerebellum in cognitive theory of mind using voxel-based lesion mapping

Theory of Mind (ToM) is a social-cognitive skill that allows the understanding of the intentions, beliefs, and desires of others. There is a distinction between affective and cognitive ToM, with evidence showing that these processes rely on partially distinct neural networks. The role of the cerebellum in social cognition has only been rarely explored. In this study, we tested whether the cerebellum is necessary for cognitive and affective ToM performance. We investigated adults with traumatic brain injury (n = 193) and healthy controls (n = 52) using voxel-based lesion-symptom mapping (VLSM) and by measuring the impact on functional connectivity. First, we observed that damage to the cerebellum affected pure Cognitive ToM processing. Further, we found a lateralization effect for the role of the cerebellum in cognitive ToM with participants with left cerebellar injury performing worse than those with right cerebellar injury. Both VLSM and standard statistical analysis provided evidence that left cerebellar Crus I and lobule VI contributed to ToM processing. Lastly, we found that disconnection of the left thalamic projection and the left fronto-striatal fasciculus was associated with poor cognitive ToM performance. Our study is the first to reveal direct causal neuropsychological evidence for a role of the cerebellum in some but not all types of ToM, processing. It reinforces the idea that social cognition relies on a complex network functionally connected through white matter pathways that include the cerebellum. It supports evidence that the neural networks underpinning the different types of ToM can be differentiated.

Characterizing Emotion Recognition and Theory of Mind Performance Profiles in Unaffected Siblings of Autistic Children.

Emotion recognition skills and the ability to understand the mental states of others are crucial for normal social functioning. Conversely, delays and impairments in these processes can have a profound impact on capability to engage in, maintain, and effectively regulate social interactions. Therefore, this study aimed to compare the performance of 42 autistic children (Mage = 8.25 years, SD = 2.22), 45 unaffected siblings (Mage = 8.65 years, SD = 2.40), and 41 typically developing (TD) controls (Mage = 8.56 years, SD = 2.35) on the Affect Recognition (AR) and Theory of Mind (TOM) subtests of the Developmental Neuropsychological Assessment Battery. There were no significant differences between siblings and TD controls. Autistic children showed significantly poorer performance on AR when compared to TD controls and on TOM when compared to both TD controls and unaffected siblings. An additional comparison of ASD, unaffected sibling and TD control subsamples, matched on full-scale IQ, revealed no group differences for either AR or TOM. AR and TOM processes have received less research attention in siblings of autistic children and remain less well characterized. Therefore, despite limitations, findings reported here contribute to our growing understanding of AR and TOM abilities in siblings of autistic children and highlight important future research directions.

Resonating Minds\u2014Emergent Collaboration Through Hierarchical Active Inference

Working together on complex collaborative tasks requires agents to coordinate their actions. Doing this explicitly or completely prior to the actual interaction is not always possible nor sufficient. Agents also need to continuously understand the current actions of others and quickly adapt their own behavior appropriately. Here we investigate how efficient, automatic coordination processes at the level of mental states (intentions, goals), which we call belief resonance, can lead to collaborative situated problem-solving. We present a model of hierarchical active inference for collaborative agents (HAICA). It combines efficient Bayesian Theory of Mind processes with a perception–action system based on predictive processing and active inference. Belief resonance is realized by letting the inferred mental states of one agent influence another agent’s predictive beliefs about its own goals and intentions. This way, the inferred mental states influence the agent’s own task behavior without explicit collaborative reasoning. We implement and evaluate this model in the Overcooked domain, in which two agents with varying degrees of belief resonance team up to fulfill meal orders. Our results demonstrate that agents based on HAICA achieve a team performance comparable to recent state-of-the-art approaches, while incurring much lower computational costs. We also show that belief resonance is especially beneficial in settings where the agents have asymmetric knowledge about the environment. The results indicate that belief resonance and active inference allow for quick and efficient agent coordination and thus can serve as a building block for collaborative cognitive agents.

Theory of mind in dysphoric and non­-dysphoric adults: An ERP study of true-­ and false-­belief reasoning

ABSTRACT Theory of mind (ToM) – the understanding that others’ behaviors are connected with internal mental states – is an important part of everyday social cognition. There is increasing behavioral evidence that ToM reasoning can be affected by mood. To gain insight into the ways sad mood may affect the underlying mechanisms of ToM reasoning, we recorded event-related brain potentials (ERPs) as dysphoric (N = 16) and non-dysphoric (N = 24) participants reasoned about a protagonist’s true or false beliefs about an object’s location. Results showed significant group effects on early components of the ERP – individuals in the dysphoric group showed greater amplitudes for the anterior N1 and N2/P2 components relative to those in the non-dysphoric group. Later in the ERP, non-dysphoric individuals showed evidence of neurocognitive dissociations between true and false belief. Dysphoric individuals, however, did not show evidence for these later dissociations. This evidence suggests that dysphoria may be associated with effortful reasoning about other’s mental states, even when that effort is not necessary (i.e., when reasoning about true beliefs). We discuss the implications of these findings for understanding how mood affects ToM reasoning and for how especially deliberative ToM processing in dysphoria may lead to social difficulties.

Gaze cueing, mental States, and the effect of autistic traits

The ability to interpret and follow the gaze of our social partners is an integral skill in human communication. Recent research has demonstrated that gaze following behaviour is influenced by theory of mind (ToM) processes. However, it has yet to be determined whether the modulation of gaze cueing by ToM is affected by individual differences, such as autistic traits. The aim of this experiment was to establish whether autistic traits in neurotypical populations affect the mediation of gaze cueing by ToM processes. This study used a gaze cueing paradigm within a change detection task. Participants’ perception of a gaze cue was manipulated such that they only believed the cue to be able to ‘see’ in one condition. The results revealed that participants in the Low Autistic Traits group were significantly influenced by the mental state of the gaze cue and were more accurate on valid trials when they believed the cue could ‘see’. By contrast, participants in the High Autistic Traits group were also more accurate on valid trials, but this was not influenced by the mental state of the gaze cue. This study therefore provides evidence that autistic traits influence the extent to which mental state attributions modulate social attention in neurotypical adults.

Identifying Other People’s Perspective and their Facial Emotions – A Comparison between Patients on Long-term Second-generation Antipsychotic Treatment for Schizophrenia and Neurotypical Controls

Previous studies report that the inhibition of one’s own perspective in favour of acknowledging somebody else’s perspective relates to the neurotypical development of Theory of Mind (ToM) processes. ToM processing seems to be negatively affected in patients diagnosed with schizophrenia (PwS). Different tasks, using different populations, have been used to examine ToM (e.g. Hinting, facial emotion recognition, on-line perspective-taking), making generalizations problematic. We investigated ToM processing, using different paradigms, in one patient group on long-term second-generation antipsychotic treatment for schizophrenia and in neurotypical controls. Methods: Twenty-five patients on treatment with second-generation anti-psychotic medication for schizophrenia for more than ten years and neurotypical controls took part in a Hinting task, a facial emotion recognition task, and an on-line visual computational perspective-taking task. A battery of neuropsychological tests provided the input of a Principal Component Analysis (PCA). Results: Patients performed significantly less effectively than controls on the Hinting Task, and even patients in remittance struggled more with the task. No significant differences in facial emotion recognition between groups were found. The on-line perspective-taking task results revealed that controls, but not patients, presented an intrusion of the other perspective when judging their own perspective (altercentric behaviour). Reaction time results revealed that patients were significantly slower than controls when evaluating the “Other” perspective. The results of the perspective-taking task were examined further by relating them to components from the PCA. Errors in perspective-taking appeared correlated mostly to difficulties in mentalizing and cognitive control (neurotypical participants) and to hinting comprehension skills (patients). Conclusions: Results suggest that mentalizing and cognitive control are relevant functions for perspective-taking and that even after long-term treatment with second-generation antipsychotics, patients still have more difficulties in judging the Other perspective. The facial emotion recognition task suggested that facial emotion recognition is a separate interpretation skill not directly related to ToM