The aim of the study. Using the latest data of Geoinform of Ukraine, to carry out economic and geographical zoning of the territory of Podillya by mineral resources in order to identify spatial and temporal and dynamic patterns of concentration of mineral deposits, their place and role in the economic complex of the region, substantiation of proposals for optimization of its structure and optimization. Research results. Within the Podilskyi macrodistrict, six mineral-raw areas were distinguished: Vinnytsia, Khmelnytskyi, Tovtry, Chortkiv, Western and Podnistrovskyі. All districts (except Chortkiv and Podnistrovskyi) are of a complex type, that is, mineral resources are concentrated within their limits in the form of macrobunches, deposits, separate deposits. In particular, it is established that the main components of the component structure of mineral resources of Podillya are different types of construction materials. Agrochemical and technological raw materials are of subordinate importance. The isolated mineral resources are characterized by a well-defined set of major and specific (area-specific) mineral resources and a distinct genetic link between the latter and the individual stratigraphic and structural-geomorphological taxones of the territory. Most territorial structures of the region's mineral resources are complex and only a few are classified as grouped. Within the region, multicomponent concentrations of mineral deposits and deposits dominate, in which raw materials for the construction industry most often play a dominant role.On the basis of the explored deposits of solid mineral resources of the region, several mineral-oriented mining hubs were formed and are functioning: Shepetivka-Polonne, Glukhiv-Turbiv, Slavuta and Kamianets-Podilskyi - Chemerivtsi. The fields of medicinal and medical-table waters of Podillya are basic for the formation in the region of territorial and recreational complexes: Konopkiv, Sataniv-Makiv and Khmilnyk. Scientific novelty. Own interpretation of such territorial structural unit of mineral resources as an area is given, regionalization of Podillya territory by combinations of mineral resources is carried out for the first time, the set of basic and specific (peculiar to this area only) types of mineral raw materials and a distinct genetic link of the latter with separate stratigraphs are established - geomorphological taxons of the territory, which are separately formed on the basis of combinations of mineral resources, mining sites and their specificasy was outlined. Practical importance. Economic and geographical zoning of the Podillya area by mineral resources is conducted which will help to form a reliable, holistic view of the actual resource potential of the region and to plan and conduct on this basis by local administrative bodies aimed at optimizing the structure of the present mineral resources and raw materials.