Terms Of Potential Research Articles

Skin repairing potential of ellagic acid-loaded zein nanoparticles: Chemical and biopharmaceutical characterization, enzymatic inhibition and cytotoxicity over keratinocytes

Zein has demonstrated the ability to carry different therapeutic molecules in the form of nano delivery systems. Ellagic acid (EA) has improved its biological properties when associated with zein. In this study, we aimed to evaluate the biopharmaceutical and in vitro pharmacological potential on skin maintenance and repairing processes, sun protection and cytotoxicity. The nanoparticles were produced by nanoprecipitation and characterized in terms of morphology, size, polydispersity, zeta potential, encapsulation efficiency, drug loading and release efficiency. The effect of ellagic acid loaded-zein nanoparticles over enzymes related to the skin protective and repairing processes was accessed. Anti-hyaluronidase, anti-lipoxygenase, anti-elastase, anti-collagenase, anti-tyrosinase and photoprotective activities were determined spectrophotometrically, while the hemolytic activity was evaluated using erythrocytes and MTT and NRU assays were used to evaluate the cytotoxicity over immortalized human keratinocytes (HaCaT) and squamous carcinoma cells (A431). The chemical interactions between EA and zein were studied by steady-state fluorescence spectroscopy. EA-loaded zein nanoparticles (NE) were spherical, homogeneous and monodisperse, with a size of 370 nm, encapsulation efficiency over 82%. The nanoparticles demonstrated a sustained release profile under different pH. Regarding the anti-enzymatic activities, NE presented an inhibitory potency over 38% for all enzymes tested. NE did not present hemolytic activity and showed limited cytotoxicity over HaCaT cells. Moreover, NE also presented an SPF of 29.88. The interaction between zein and EA was driven by a dynamic quenching mechanism. Therefore, NE present a great potential to aid in skin protection/repairing processes, such as wound treatments.

0764 End of daylight saving and sleep children 4-24 months

Abstract Introduction Daylight saving time (DST) imposes a twice yearly 1h change in local clock time. Although it may seem a small adjustment, there is increasing awareness of the potential acute and long term effects at the individual and population level. Several studies have shown detrimental effects on sleep patterns, but mostly focusing on adults. Only one study has looked at the effect in infants’ sleep of change from standard time (ST) to DST, reporting negative effects. One study limitation was the reliance on parental reports of infant sleep. In addition, effects of the change from DST to ST are unknown. We hypothesize that the change from DST to ST would lead to earlier rise times, leading to sleep loss in the week following the change. Methods Caregivers of 510 children ages 3-24 mos (M=9.8 mos) tracked their child’s sleep using Nanit baby-monitor. Sleep metrics analyzed were: Nighttime sleep duration (NSD) and midpoint, number of night-wakings and sleep efficiency. Wilcoxon rank sum tests compared the average of each sleep metric for the week preceding the time change (Oct 31st-Nov 4th 2022, Baseline) with sleep metrics for each night of the following week (Nov 7-11 2022, post-DST week). Analyses were repeated stratifying by age group (4-6,7-12 and 13-24 months). Results After the time change, there was no change in NSD or sleep efficiency. There was a significant decrease in the number of night-wakings for infants 3-6 months, with an average of 0.5 fewer wakings per night compared to Baseline (Baseline mean=5 wakings). Midpoint was significantly earlier for all ages by an average of 10min, every day of the post-DST week. Conclusion The return to ST affected infants’ sleep midpoint. Observed effects were minor compared to those reported in previous literature for the ST to DST change, in line with other fields like cardiovascular health. This easier adjustment could be attributed to the fact that during DST there is an increased mismatch between body clock and social clock time, thus infants more readily adjust to a return to ST which minimizes this mismatch. Support (if any) This research was supported by Nanit

Investigating the mitigation of greenhouse gas emissions from municipal solid waste management using ant colony algorithm, Monte Carlo simulation and LCA approach in terms of EU Green Deal

This study majorly aimed to determine the effect of optimization on transport routes on the reduction of greenhouse gas (GHG) emissions from municipal solid waste management (MSM) within the scope of European Union (EU) Green Deal. Optimization of collection and transportation routes has been regarded as an effective methodology in order to mitigate the GHG emissions of municipal waste management, recently. Optimization of routes has been obtained using ant colony algorithm (ACA) and Monte Carlo simulation, in this study. In this context, this study investigated to reduce GHG emissions from municipal waste management using optimization of transportation routes in Diyarbakir city in Turkey. Firstly, GHG emissions which are carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) emissions from waste collection and transport have been calculated using a new developed model based on Tier-I method. Then, Monte Carlo simulation has been used to figure out the GHG emissions. Finally, life cycle assessment (LCA) approach has been applied to determine the GHG emissions. According to the route optimization resulting ACA methodology, nearly 47.43% of reduction on each GHG emissions. Approximately, 58%, 38% and 51% of reduction on CO2, CH4 and N2O emissions respectively has been achieved, in the result of the route optimization using Monte Carlo simulation. The results of LCA methodology revealed that the reduction reached up 45.71% on GHG emissions in terms of Global Warming Potential (GWP). The reduction amounts have been overlapped with each other.

Normalized Solutions to the Fractional Schrödinger Equation with Potential

This paper is concerned with the existence of normalized solutions to a class of Schrödinger equations driven by a fractional operator with a parametric potential term. We obtain minimization of energy functional associated with that equations assuming basic conditions for the potential. Our work offers a partial extension of previous results to the non-local case.

Archaeometallurgical Characterization of Two Lombard Early Medieval Bloomery Slags from Ponte di Val Gabbia I Site (Northern Italy)

An archaeometallurgical characterization of two iron smelting tap slags recovered from the early medieval site of Ponte di Val Gabbia I (Brescia, northern Italy) was performed. The main goal was to infer from the slags the working conditions of the ancient bloomery furnace in terms of temperature and oxygen chemical potential. The petrology of both slags was investigated by light optical microscopy and scanning electron microscopy, while their chemical compositions were measured via scanning electron microscopy coupled with X-ray dispersive spectroscopy. High-resolution Raman micro-spectrometry was used to confirm the identification of the mineralogical phases. The software Rhyolite-MELTS was used to compute the liquidus temperatures of the two slags, which were found to be 1120 °C and 1146 °C. These temperatures approximate the working temperature of the bloomery furnace. A thermodynamic-based approach was adopted to estimate the redox conditions of the reducing atmosphere of the smelting furnace, revealing that the two slags formed in different redox environments. Specifically, the resulting oxygen chemical potentials were −382.61 kJ/mol and −243.80 kJ/mol at the liquidus temperatures of 1120 °C and 1146 °C, respectively.

Vortex supersolid in the XY model with tunable vortex fugacity

In this paper, we investigate the XY model in the presence of an additional potential term that independently tunes the vortex fugacity favouring their nucleation. By increasing the strength of this term and thereby the vortex chemical potential µ, we observe significant changes in the phase diagram with the emergence of a normal vortex-antivortex lattice as well as a superconducting vortex-antivortex crystal (lattice supersolid) phase. We examine the transition lines between these two phases and the conventional non-crystalline one as a function of both the temperature and the chemical potential. Our findings suggest the possibility of a peculiar tricritical point where second-order, first-order, and infinite-order transition lines meet. We discuss the differences between the present phase diagram and previous results for two-dimensional Coulomb gas models. Our study provides important insights into the behaviour of the modified XY model and opens up new possibilities for investigating the underlying physics of unconventional phase transitions.

The ‘Crago Process’ and Its Applicability to a South African Sedimentary Phosphate Deposit

The traditional approach for the beneficiation of South African siliceous sedimentary phosphate ores has been reverse cationic flotation. The robustness of this approach, however, has been a concern due to its sensitivity to parameters such as slimes content, headgrade (P2O5 and SiO2 content), reagent dosages and conditioning times. The phosphate mineralisation for the ore body under investigation is predominantly carbonate fluorapatite composed of mainly quartz and apatite and minor amounts of chlorite, ilmenite and carbonates. Beneficiation of low grade sedimentary ores containing calcareous impurities, such as calcite and/or dolomite in addition to siliceous gangue, is required to meet the increasing demand; therefore, much research has been carried out to find an alternative technique to beneficiate this material. This paper investigates traditional flotation approaches versus the currently adopted ‘Crago Process’. Comparative results are presented in terms of upgrade potential for the production of concentrate rock for downstream applications. The novelty of the ‘Crago Process’ lies in its double stage approach, i.e. direct fatty acid flotation followed by reverse cationic amine flotation. The Crago process was able to achieve higher upgrades reporting at 32.1% P2O5 compared to conventional cationic flotation only achieving grades of 18.5% P2O5. Furthermore, the recovery gain was 3%.

A deformed global spherical optical potential to describe proton scattering off statically deformed heavy nuclei

We examine the applicability of the adiabatic approximation in the case of proton scattering off statically deformed actinide and rare-earth nuclei. This is achieved by deforming a global spherical potential to allow coupling of the elastic channel to inelastic rotational excitation states. Only the radius of volume term of the spherical potential is deformed. The rest of the potential parameters are used unaltered. The model reproduced the scattering observables well. The results are congruent to those of a global model in the literature that determines the potential parameters by fitting the experimental data within a channel coupling formalism. A necessary requirement for the adiabatic approximation to hold is that the speed of the proton should be much larger than the angular speed of the deformed target nucleus. The fact that our calculated angular distributions and total cross sections agree well with experiment indicates that this condition is still valid despite the possibility of the proton being decelerated by the coulomb force as it approaches the deformed nucleus.

Spinor wave function of the Universe in non-minimally coupled varying constants cosmologies

In this paper, we introduce a non-minimally coupled varying speed of light and varying gravitational constant cosmological toy model. Using the Eisenhart–Duval lifting method, we extend the original minisuperspace of the model and depict the evolution of the system in the presence of the potential term as a geometrical flow associated with the lifted metric. We write the Dirac–Wheeler–DeWitt equation, which solution is a spinor wave function of the Universe. Then we find the solution of the Dirac–Wheeler–DeWitt equation, which describes the emergence of two early universe–antiuniverse pairs that differ with the conserved quantity, which is an analog of the spin.

10-Hydroxy Decanoic Acid-Based Vesicles as a Novel Topical Delivery System: Would It Be a Better Platform Than Conventional Oleic Acid Ufasomes for Skin Cancer Treatment?

10-hydroxy decanoic acid (HDA), a naturally derived fatty acid, was used for the preparation of novel fatty acid vesicles for comparison with oleic acid (OA) ufasomes. The vesicles were loaded with magnolol (Mag), a potential natural drug for skin cancer. Different formulations were prepared using the thin film hydration method and were statistically evaluated according to a Box-Behnken design in terms of particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE). The ex vivo skin permeation and deposition were assessed for Mag skin delivery. In vivo, an assessment of the optimized formulae using 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin cancer in mice was also conducted. The PS and ZP of the optimized OA vesicles were 358.9 ± 3.2 nm and -82.50 ± 7.13 mV compared to 191.9 ± 6.28 nm and -59.60 ± 3.07 mV for HDA vesicles, respectively. The EE was high (>78%) for both types of vesicles. Ex vivo permeation studies revealed enhanced Mag permeation from all optimized formulations compared to a drug suspension. Skin deposition demonstrated that HDA-based vesicles provided the highest drug retention. In vivo, studies confirmed the superiority of HDA-based formulations in attenuating DMBA-induced skin cancer during treatment and prophylactic studies.

Boosting the Electrocatalytic Performance of CoPt Alloy with Enhanced Electron Transfer via Atomically Dispersed Cobalt Sites.

Designing electrocatalysts with strong electronic metal-support interaction can effectively regulate the electronic properties of metal active centers, therefore maximizing the catalytic performance. As a proof of concept, heteroatoms doped carbon with CoPt alloy and isolated Co single atoms (CoPtCoSA@NSC) are synthesized using CoPt bimetallic metal-organic framework as the precursor in this work. The existence of CoSA on the carbon substrate leads to more electron transfer between CoPt and the support, and appropriate upward shift of the d band center of the catalysts, which can effectively reduce the reaction barrier of rate determine step and boost the catalytic performance of CoPt alloy. The enhanced catalytic activity and stability of CoPtCoSA@NSC are demonstrated experimentally. Remarkably, the overpotential for hydrogen evolution reaction is only 23mV at 10mAcm-2 and the half-wave potential for oxygen reduction reaction is 0.90V, both exceeding the commercial Pt/C benchmark. In addition, CoPtCoSA@NSC also exhibits great potential as a cathode electrocatalyst for Zn-air battery, in terms of large open circuit potential of 1.53V, high power density of 184mWcm-2 , as well as superior cycling stability. This work provides a novel strategy for regulating the electronic structure and catalytic performance of alloy based electrocatalysts.

Borderline Hepatocellular Adenomas: A Practical Diagnostic Approach Based on Pathologic and Molecular Features

Borderline hepatocellular adenomas (BL-HCA) are characterized by focal architectural/cytologic atypia and reticulin loss, features that are insufficient for a definitive diagnosis of hepatocellular carcinoma (HCC). The diagnosis and management of BL-HCA are challenging as their biological behavior, especially in terms of malignant potential, is still debated. We aimed to compare the clinicopathologic and molecular features of BL-HCA with those of typical HCA (T-HCA), HCA with malignant transformation (HCC on HCA), and HCC to assess the risk of malignancy. One hundred six liver resection specimens were retrospectively selected from 2 reference centers, including 39 BL-HCA, 42 T-HCA, 12 HCC on HCA, and 13 HCC specimens. Somatic mutations, including TERT promoter mutations associated with HCA malignant transformation and the gene expression levels of 96 genes, were investigated in 93 frozen samples. Additionally, TERT promoter mutations were investigated in 44 formalin-fixed, paraffin-embedded samples. The clinical features of patients with BL-HCA were similar to those of patients with T-HCA, patients being mainly women (69%) with a median age of 37 years. The median tumor size was 7.5 cm, 64% of patients had a single nodule, and no recurrence was observed. Compared with T-HCA, BL-HCA was significantly enriched in β-catenin–mutated HCA in exon 3 (41% vs 6%; P < .001). Unsupervised statistical analysis based on gene expression showed that BL-HCA overlapped with T-HCA and HCC on HCA, favoring a molecular continuum of the tumors. TERT promoter mutations were observed only in HCC on HCA (42%) and in HCC (38%). In conclusion, these results suggest that despite their worrisome morphologic features, the clinicopathologic and molecular features of BL-HCA are much closer to those of T-HCA than those of HCC on HCA or HCC. This strongly supports the usefulness of combining morphologic and molecular analyses in a practical diagnostic approach for guiding the management of BL-HCA.

LCA approach for environmental impact assessment within the maritime industry: Re-design case study of yacht’s superstructure

Sustainable development, one of the main challenges of our time, is a policy focused on the perfect balance between three fundamental pillars: environmental, economic and social sustainability. As regards the environmental protection, the Life Cycle Assessment (LCA) methodology allows to evaluate the sustainability profile of the overall Life-Cycle (LC) of products, processes and services, based on an inventory (in terms of materials/energy consumption and emissions/waste production) referred to all LC stages. The paper describes an application of LCA in the maritime transportation field, after a careful analysis of the state of the art. In particular, the case study consists in the environmental comparison of two alternative design solutions for the superstructure of a Azimut-Benetti yacht, designed by Corporate R&amp;D department and manufactured in one of Benetti botyards. The competing construction options are a Glass Fiber reinforced Vinylester-isophthalic Resin (GFVR) and a Carbon Fiber reinforced Epoxy Resin (CFER) component, and they are assessed in terms of Global Warming Potential through the CML2001 Life Cyle Impact Assessment (LCIA) method. The study takes into account the entire LC of the superstructure component, divided into production (including raw materials, manufacturing and transportations), use (including both fuel consumption and exhaust air emissions) and End-of-Life (EoL). The Life Cycle Inventory (LCI) is mainly based on primary data (materials and energy consumption for manufacturing) directly provided by the construction company; missing data are retrieved from secondary sources (literature and LCI database provided by the GaBi6 environmental software). Results show that, despite the higher impact in production stage, the innovative solution allows achieving a significant quota of GWP over the entire LC (more than 16%), which is mainly associated with decreased amount of fuel needed and lowered CO2 exhaust emissions during operation. The sensitivity analysis reveals that the environmental advantage provided by the CFER design becomes bigger as both component life-time and yacht consumption increase.

Energy dissipative and positivity preserving schemes for large-convection ion transport with steric and solvation effects

Ion transport plays a crucial role in biophysical and electrochemical applications. While being modeled by the classical Poisson–Nernst–Planck (PNP) equations, many ionic features are ignored in the course-graining modeling of ionic interactions. In this work, we study ion transport by modified PNP equations including effects arising from steric interactions and the Born solvation, which both could cause strong convection. The modified NP equations are first rewritten in a gradient-flow reformulation that involves mobility and chemical potential terms. The mobility is then approximated by upwind fluxes with various flux limiters on the half-grid points, and the chemical potential terms are then implicitly approximated by central differencing. The resulting first-order in time scheme is proved to be energy dissipative unconditionally. Furthermore, the unconditional existence of positive numerical concentration is proved by making use of the singularity of the entropy term, which prevents the concentration from approaching zero. The flux with the Minmod or Osher limiter is reduced to a second-order upwind flux in the strong convective limit. Numerical tests are performed to confirm the expected order of accuracy and the properties of the developed scheme at discrete level. In addition, our numerical experiments demonstrate that the developed schemes with limiters can achieve higher accuracy than the Scharfetter-Gummel scheme and classical upwind scheme in tests with strong convection. Finally, the developed schemes are applied to numerically assess the effects of Coulombic interaction, steric interaction, and Born solvation on the rectifying transport of ions through nanopores.

SILK FIBROIN-BASED ANASTROZOLE NANOPARTICLE LOADED IN SITU INJECTABLE: DEVELOPMENT AND CHARACTERIZATION

Objective: The study aims to find a suitable method of developing silk fibroin-based anastrozole nanoparticles and formulate in situ injectables by loading the optimized nanoparticle formulation for the sustained release treatment of breast cancer. Methods: The nanoparticles were formulated utilizing two different methods, solvent change and precipitation approach using silk fibroin. Prepared nanoparticles characterized in terms of size, zeta potential, polydispersity, and entrapment efficiency. The chosen optimized formulation (SF-ANS-NPs-1) was subsequently analyzed for compatibility investigations by Fourier-transform infrared spectroscopy (FT-IR), thermal analysis, surface morphology, x-ray diffraction, transmission electron spectroscopy, cumulative drug release, and stability studies as per ICH guidelines. Followed by formulating and evaluating in situ injectable gel using pluronic F-127. Results: A particle size of 181.70±1.3 nm was reported by the optimized SF-ANS-NPs-1 formulation. FT-IR and thermal studies confirmed the compatibility of the drug with the polymers, and x-ray diffraction studies indicated crystalline nature. Surface morphology analysis indicated nano-size particle formation. A cumulative drug release (%CDR) of 94.15% was noted at the 168th hour. The results of the stability studies were indicated to be consistent over 90 d. In situ gel formulation showed desired spreadability, sol-gel transition temperature (37±0.5 ℃), viscosity (9.37±1.2 mPa·s), desired acidic pH, and a sustained release for 21 d (98.11%) with three months accelerated stability. Conclusion: The results suggested that the combination of anastrozole with silk fibroin in the form of nanoparticles and in situ gelling systems could be an undoubtedly effective delivery method for prolonging breast cancer therapy.

Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferation and Migration.

The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disadvantageous physico-chemical properties, leading to restricted clinical use. In this work, a complex mixture of PEGylated lipid, Glyceryl monoester, 18-β-Glycyrrhetinic Acid and Menthol was designed to entrap Resveratrol (RSV) as the active ingredient and further produce lipid nanoparticles (LNPs) by homogenization followed by high-frequency sonication. The nanosystem was properly characterized in terms of particle size (DLS, SEM), zeta potential, drug loading, antioxidant power (DPPH), release behaviour, cytocompatibility, wound healing and antibiofilm properties. The optimized lipid mixture was homogeneous, melted at 57-61 °C and encapsulated amorphous RSV (4.56 ± 0.04% w/w). The RSV-loaded LNPs were almost monodispersed (PDI: 0.267 ± 0.010), with nanometric size (162.86 ± 3.12 nm), scavenger properties and suitable DR% and LE% values (96.82 ± 1.34% and 95.17 ± 0.25%, respectively). The release studies were performed to simulate the wound conditions: 1-octanol to mimic the lipophilic domains of biological tissues (where the First Order kinetic was observed) and citrate buffer pH 5.5 according to the inflammatory wound exudate (where the Korsmeyer-Peppas kinetic was followed). The biological and microbiological evaluations highlighted fibroblast proliferation and migration effects as well as antibiofilm properties at extremely low doses (LNPs: 22 μg/mL, corresponding to RSV 5 µM). Thus, the proposed multicomponent LNPs could represent a valuable RSV delivery platform for wound healing purposes.

Impact of Canine Amniotic Mesenchymal Stem Cell Conditioned Media on the Wound Healing Process: In Vitro and In Vivo Study.

The aim of this study was to provide a beneficial treatment effect of mesenchymal stem cell products derived from the canine amniotic membrane (AM-MSC) on the complicated wound healing process in dogs. AM-MSCs were characterized in terms of morphology, phenotypic profile, and multilineage differentiation potential. The in vitro study of the effect of canine amniotic mesenchymal stem cell conditioned media (AMMSC-CM) on a primary skin fibroblast cell culture scratch assay showed a decrease in the measured scratch area of about 66.39% against the negative control (Dulbecco's Modified Eagle's Medium-32.55%) and the positive control (Dulbecco's Modified Eagle's Medium supplemented with FGF2, N2, B27, and EGF-82.077%) after 72 h treatment. In the experimental study, seven dogs with complicated nonhealing wounds were treated with a combination of antibiotics, NSAIDs, and local AMMSC-CM application. After 15 days of therapy, we observed a 98.47% reduction in the wound surface area as opposed to 57.135% in the control group treated by conventional therapy based on debridement of necrotic tissue, antibiotic therapy, pain management, and change of wound dressing.

A Comparison Estimate for Singular p-Laplace Equations and Its Consequences

Comparison estimates are an important technical device in the study of regularity problems for quasilinear possibly degenerate elliptic and parabolic equations. Such tools have been employed indispensably in many papers of Mingione, Duzaar-Mingione, and Kuusi-Mingione, etc. on certain measure datum problems to obtain pointwise bounds for solutions and their full or fractional derivatives in terms of appropriate linear or nonlinear potentials. However, a comparison estimate for $p$-Laplace type elliptic equations with measure data is still unavailable in the strongly singular case $1< p\leq \frac{3n-2}{2n-1}$, where $n\geq 2$ is the dimension of the ambient space. This issue will be completely resolved in this work by proving a comparison estimate in a slightly larger range $1<p<3/2$. Applications include a `sublinear' Poincar\'e type inequality, pointwise bounds for solutions and their derivatives by Wolff's and Riesz's potentials, respectively. Some global pointwise and weighted estimates are also obtained for bounded domains, which enable us to treat a quasilinear Riccati type equation with possibly sublinear growth in the gradient.

High order accurate and convergent numerical scheme for the strongly anisotropic Cahn–Hilliard model

AbstractWe propose and analyze a second order accurate in time, energy stable numerical scheme for the strongly anisotropic Cahn–Hilliard system, in which a biharmonic regularization has to be introduced to make the equation well‐posed. A convexity analysis on the anisotropic interfacial energy is necessary to overcome an essential difficulty associated with its highly nonlinear and singular nature. The second order backward differentiation formula temporal approximation is applied, combined with Fourier pseudo‐spectral spatial discretization. The nonlinear surface energy part is updated by an explicit extrapolation formula. Meanwhile, the energy stability analysis is enforced by the fact that all the second order functional derivatives of the energy stay uniformly bounded by a global constant. A Douglas‐Dupont type regularization is added to stabilize the numerical scheme, and a careful estimate ensures a modified energy stability with a uniform constraint for the regularization parameter . In turn, the combination with an appropriate treatment for the nonlinear double well potential terms leads to a weakly nonlinear scheme. More importantly, such an energy stability is in terms of the interfacial energy with respect to the original phase variable, which enables us to derive an optimal rate convergence analysis.

Evaluation of liquefaction triggering potential in Italy: a seismic-hazard-based approach

Abstract. In the present study, we analyze ground-motion hazard maps and hazard disaggregation in order to define areas in Italy where liquefaction triggering due to seismic activity can not be excluded. To this end, we refer to the triggering criteria (not to be confused with liquefaction susceptibility criteria, which essentially take into account soil type and depth to groundwater) proposed by the Italian Guidelines for Seismic Microzonation, which are described in the main body of the paper. However, the study can be replicated in other countries that adopt different criteria. The final goal is the definition of a screening map for all of Italy that classifies sites in terms of liquefaction triggering potential according to their seismic hazard level. The map, which is referred to with the Italian acronym MILQ – Mappa del potenziale d'Innesco della LiQuefazione (i.e., map of liquefaction triggering potential), and the associated data are freely accessible at the following web address: https://distav.unige.it/rsni/milq.php (last access: 28 April 2023). Our results can be useful to guide land-use planners in deciding whether liquefaction is a hazard that needs to be considered within the planning processes or not. Furthermore, they can serve as a guide for recommending geological and geotechnical investigations aimed at the evaluation of liquefaction hazards or, conversely, rule out further studies with consequent savings in efforts and money.