The preparation of flexible materials as strain sensors for wearable devices with good mechanical and electrical properties at low temperatures is a major challenge. In this study, novel low-temperature strain sensors are fabricated based on the template method of integral molding cured CNTs/GNPs/PDMS composites. The one-piece molding process results in composites with excellent mechanical properties and environmental adaptability (temperature insensitivity, hydrophobicity, and humidity resistance). CNTs/GNPs/PDMS strain sensors that respond to tensile and compressive strains, respectively, can be obtained by changing only the shape of the template. They both offer a wide operating range, high gauge factors (GFs), and long-term reliability over the entire temperature range (−20–40 °C). At 20 and −20 °C, CNTs/GNPs/PDMS tensile and compressive strain sensors are used to monitor various human activities and human physical signals. This study provides a new promising strategy for the construction of future wearable devices for low-temperature condition applications.