Porcelains and glass-ceramics have been used to produce CAD-milled veneers and crowns for zirconia copings and implant-abutments. This study evaluated the bondstrength of a polymer-infiltrated-ceramic-network to zirconia using two adhesive cement systems: Panavia 21 and Multilink Automix. Lithium disilicate and feldspathic porcelain were also tested as reference CAD-On materials. Long beams (3x6x40 mm³) of zirconia and short beams (3x6x15 mm³) of the CAD-On materials were prepared. Zirconia and each CAD-On material were bonded in a crossbeam arrangement and subjected to a modified tensile bond-strength test. Half of the samples in each group (n=10) were tested 5 days after bonding (baseline) and the remaining (n=10) underwent aging (50,000 thermocycles at 5°C and 55°C) prior to bond-strength testing. The effects of material, cement, and aging on the tensile bond-strength were tested using a three-way ANOVA. The reference lithium disilicate/Multilink system showed no significant differences in bond strength compared to polymer-infiltrated-ceramic-network and porcelain. The long-term retention of polymer-infiltrated-ceramic-network was not statistically different compared to the baseline values and the two reference materials. With comparable bond strength between all materials, polymer-infiltrated-ceramic-network is the favorable choice for CAD-On to zirconia copings and implant-abutments due to its superior resistance to fatigue fracture relative to porcelain.