The actuality and relevance of the problem is determined by the importance of transformations in the structure of science, represented by the growth of interdisciplinary researches, as well as a change in the strategy of cognitive activity, definitely stated in the synthesis of science and technologies. The answer to the question of how scientific knowledge is changing is important for choosing an adequate social development strategy, since the role of science and scientific technologies in modern society is dramatically growing. The purpose of the article is to set out the social and philosophical reflection of social and cultural consequences of mutual impact of the high technologies and the interdisciplinary researches in the information society context. The positive and negative sides of the mutual influence of the cognitive and innovative instruments of the natural, social, technical and human sciences, under the conditions of information and communication, nano- and bio-technologies development are manifested. Interdisciplinary researches are newly problematizing the concept of expertise, which should be an interdisciplinary synthesis and cannot be obtained within a certain discipline. The growing phenomenon of interdisciplinary science, which manifests itself in the fusion of technology and society, the emergence of human-machine hybrids, which causes serious anthropological and sociocultural problems, imply new challenges for professional epistemologists, dictate a public need for knowledge of the causes and consequences of the high technologies impact on people and society as a whole.