Knee osteoarthritis (OA) is a large contributor to disability and has a significant economic impact as a result of treatment costs. Laterally-wedged foot orthotics have been suggested as a conservative treatment option that is successful in reducing the knee adduction moment which is associated with knee OA progression. Therapeutic taping of the foot may provide an alternative to foot orthotics by providing a cheaper and more readily available intervention. No evidence currently exists that demonstrates parallel effects between therapeutic taping and foot orthotics on the knee adduction moment. PURPOSE: To determine if therapeutic taping of the foot will reduce the peak knee adduction moments compared to a barefoot condition in asymptomatic men and women. METHODS: Twenty-five volunteers 18-30 years participated in the study. The subjects underwent gait analysis while walking at a self-selected speed in a barefoot and therapeutic tape condition. The taping condition involved use of Leukotape® in an attempt to shift the ankle into eversion, simulating the presence of a lateral-wedge orthotic. An average of five trials was obtained to analyze the peak joint angles and moments at the hip, knee, and ankle in the frontal and transverse planes. A dependent t-test was utilized to assess statistical differences between the conditions. RESULTS: The statistical analysis of the peak knee adduction moment between conditions revealed no differences between conditions. As expected, the taped condition produced differences at the ankle by increasing peak eversion and subsequently decreasing eversion excursion. Interestingly, the tape condition resulted in an increased amount of tibial internal rotation with a decreased tibial internal rotation moment. The only difference observed at the knee or hip was decreased knee adduction excursion in the taped condition. CONCLUSION: The reduction in mobility at the ankle from therapeutic taping did not translate to changes at the knee associated with lateral wedging in this sample of young subjects. Differences were observed in the amount of secondary plane motion at the ankle with the taping. Although no difference at the knee was observed in these subjects, further research in individuals with diagnosed knee OA is warranted, as knee OA alters joint mobility.