In recent years, the process of economic globalization and information globalization has been speeding up, which has brought unique development opportunities to China. However, talents, especially high-end talents, play an increasingly important role in social development. Therefore, to achieve sustainable development and enhance innovation ability, we must strengthen the cultivation and utilization of high-end innovative talents, and provide talent guarantee for transformation and development. First of all, this paper analyzes the current situation of the utilization mechanism of high-end innovative talents in China, and points out that there are some problems in the utilization mechanism of high-end innovative talents in China, such as the traditional thinking constraining the development of talent mechanism, the large loopholes in talent management system, the lack of implementation of talent incentive mechanism, and the overall strength of talent training mechanism Weak, lack of talent security and development mechanism, etc., and elaborated the background and reasons of the problem, and then put forward effective suggestions and measures. Starting from the management mechanism, incentive mechanism, security mechanism, development mechanism, training mechanism and other aspects, this paper puts forward specific improvement measures for the current problems in the utilization of high-end innovative talents in China, which has important practical significance.