Following Einstein’s prediction that “Physics constitutes a logical system of thought” and “Nature is the realization of the simplest conceivable mathematical ideas”, this topical review outlines a formal extension of local realism limited by the speed of light to global realism with bipolar strings (GRBS) that unifies the principle of locality with quantum nonlocality. The related literature is critically reviewed to justify GRBS which is shown as a necessary and inevitable consequence of the Bell test and an equilibrium-based axiomatization of physics and quantum information science for brain–universe similarity and human-level intelligence. With definable causality in regularity and mind–light–matter unity for quantum superposition/entanglement, bipolar universal modus ponens (BUMP) in GRBS makes quantum emergence and submergence of spacetime logically ubiquitous in both the physical and mental worlds—an unexpected but long-sought simplification of quantum gravity with complete background independence. It is shown that GRBS forms a basis for quantum intelligence (QI)—a spacetime transcendent, quantum–digital compatible, analytical quantum computing paradigm where bipolar strings lead to bipolar entropy as a nonlinear bipolar dynamic and set–theoretic unification of order and disorder as well as linearity and nonlinearity for energy/information conservation, regeneration, and degeneration toward quantum cognition and quantum biology (QCQB) as well as information-conservational blackhole keypad compression and big bang data recovery. Subsequently, GRBS is justified as a real-world quantum gravity (RWQG) theory—a bipolar relativistic causal–logical reconceptualization and unification of string theory, loop quantum gravity, and M-theory—the three roads to quantum gravity. Based on GRBS, the following is posited: (1) life is a living bipolar superstring regulated by bipolar entropy; (2) thinking with consciousness and memory growth as a prerequisite for human-level intelligence is fundamentally mind–light–matter unitary QI logically equivalent to quantum emergence (entanglement) and submergence (collapse) of spacetime. These two posits lead to a positive answer to the question “If AI machine cannot think, can QI machine think?”. Causal–logical brain modeling (CLBM) for entangled machine thinking and imagination (EMTI) is proposed and graphically illustrated. The testability and falsifiability of GRBS are discussed.