In this article, the sampled-data-based event-triggered synchronization control for fractional and impulsive complex networks (CNs) with time-varying delay is investigated and a class of more general network structure based on the switching topologies at impulsive instants is considered. First, a class of novel fractional-order integral inequalities is produced to obtain depend-delay synchronization criteria and estimate Lyapunov–Krasovskii functions. Then, a sampled-data-based event-triggered control is designed, which can ensure synchronization of fractional and impulsive CNs (FICNs) with time-varying delay. Next, by using the Lyapunov direct method, some criteria are obtained to guarantee the synchronization of FICNs. Numerical simulations are given to demonstrate that the designed sampled-data-based event-triggered synchronization strategy can effectively not only achieve synchronization of FICNs but reduce the frequency of controller update compared to the previous related works.