Symptoms Of Burning Research Articles

Anxiolytics, Antidepressants and Autogenous training in the therapy of burning mouth syndrome

It is well known that many diseases of our system can cause various pathological changes and symptoms. Psychical disorders are considered to be the main cause of changes in the oral cavity. The most frequent psychical disturbances associated with the symptoms are: depression, anxiety and stress. Methods: The research was conducted by means of psychological questionnaires resting depression and anxiety and we tried to objectivize the burning symptom by means of a VAS scale (visual analogous scale). Results: The results we obtained suggest that by treating psychical disturbances we might obtain significant improvement in treating symptoms in the oral cavity. The results have shown that there is a significant rise in negative findings in both psychological tests and within the mouth. Anxiety tests show primarily negative values: in the first group: 90% of the respondents, in the second group 73.3%, in the third group 83.3% and in the fourth group 56.7% of the respondents. The depression test has shown that the first group of respondents displayed mainly borderline values – 53.3%, without positive values, while negative values have risen to 46.7%. The second group has increased its negative values to 96.7% of the respondents, without any positive values and with a few borderline findings: 3.3%. The third group displayed mainly negative values (76.1%) and borderline values (23.3%), with no positive findings. Conclusion: Antidepressants and anxiolytics have a prominent role in the therapy of stomatopyrosis. Autogenic training – a psychotherapeutic anxiolytic technique is the therapy of choice as far as stomatopyrosis is concerned, as it both eliminates the problems and emotionally rehabilitates the patient.

Participation of micro-organisms of dental interest in the etiology of Burning Mouth Syndrome: literature review

The Burning Mouth Syndrome (BMS) is a pathologic entity characterized by the presence of chronic symptoms of burning or pain in normal oral mucosa. It mainly affects women in the postmenopausal period, and its cause is unknown, but as there is an association with biological and psychological factors, it may assume a multifactorial etiology. Considering the unclear etiology of BMS, studies that contribute to its understanding are of great importance. In order to achieve a better understanding regarding microbial etiological factors of this disease, the aim of this review is to compile studies on possible involvement of micro-organisms of dental interest in the etiology of BMS. Studies have reported that patients with BMS harbor greater amount of intra-oral Candida and Enterobacteriaceae than patients without clinical manifestations of this disease.Different sources such as articles, books and journals, published in the world literature, were used in this research. These sources were accessed by databases like PubMed, SciELO, Scopus or search of full text. Studies in the literature have suggested that Candida and Enterococcus were correlated with BMS, although they might not necessarily be considered as an etiological factor but a predisposing factor. However, further studies that aim to elucidate relation between BMS and infectious factors are necessary.KeywordsCandida; Enterobacteriaceae; Burning mouth syndrome.

Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review

Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia with characteristic clinical pattern of progressive frontotemporal hairline recession, perifollicular erythema and hyperkeratosis and symptoms of itch and burning, occurring mainly in post-menopausal women. FFA is considered a subtype of lichen planopilaris (LPP), based on their identical histopathology. Currently, no evidence-based treatment is available for FFA. Our aim was to determine the effectiveness of available treatment options for FFA, and to identify promising treatment options for future studies. For this, literature search was conducted to find all primary studies on the treatment of FFA and LPP. From the primary studies, data were subtracted and analysed. No randomized controlled trials were found, and one controlled trial. Treatment of 114 patients is described in the literature. They received 10 different regimes, of which oral 5-alpha-reductase inhibitors were provided most often, resulting in good clinical response in 45% of them. Hydroxychloroquine resulted in good clinical response in 30% of the 29 treated patients. Topical corticosteroid preparations are ineffective in FFA. The remaining treatments were all reported in less than 10 patients. For the treatment of LPP, topical corticosteroid preparations are the first line of treatment, followed by oral cyclosporine and systemic corticosteroids, although they are characterized by a high relapse rate. Summarizing, there is currently no effective treatment of FFA, the most effective being oral 5-alpha-reductase inhibitors that possibly affect the accompanying androgenetic alopecia. We argue that oral cyclosporine A might be a good candidate for future studies on the treatment of FFA.

Serological Assessment of Samples from Patients Complaining of ?Dyspepsia?

Background: Many people consult their GP for upper gastrointestinal (GI) symptoms, which are often associated with pain or burning and discomfort in the abdomen and range from heartburn and acid regurgitation to nausea and vomiting. Historically, all of these symptoms have been grouped together under the single term ‘dyspepsia’, defined as having one or more symptoms of epigastric pain, burning, postprandial fullness, or early satiation. While gastric or oesophageal cancer is an unusual finding in patients with dyspepsia, excluding malignancy is a common reason for performing endoscopy. Methods: Quest Diagnostics has been offering the GastroPanel® assays for those patients who have been referred to the walk-in clinic complaining of ‘dyspepsia’. This is a set of three assays (Pepsinogen I, Gastrin 17 and Helicobacter pylori) and the results use an algorithm which can provide information about the stomach health and about the function of the stomach mucosa. Results: Of all the samples tested 63.5% showed no abnormalities and were reported as ‘normal function of gastric mucosa.’ These patients would be classed as having functional dyspepsia. Thirty-six samples (19.9%) were positive for Helicobacter pylori and the remaining samples had a variety of abnormal results. Conclusion: Dyspepsia is a common problem seen both by primary care physicians and gastroenterologists. Using the results from the serological analysis of the patients’ serum the clinician can delineate between gastric atrophy and a normal health stomach usually without the need to refer the patient for endoscopy.

Serological assessment of samples from patients complaining of dyspepsia

Background: Many people consult their GP for upper gastrointestinal (GI) symptoms, which are often associated with pain or burning and discomfort in the abdomen and range from heartburn and acid regurgitation to nausea and vomiting. Historically, all of these symptoms have been grouped together under the single term ‘dyspepsia’, defined as having one or more symptoms of epigastric pain, burning, postprandial fullness, or early satiation. While gastric or oesophageal cancer is an unusual finding in patients with dyspepsia, excluding malignancy is a common reason for performing endoscopy. Methods: Quest Diagnostics has been offering the GastroPanel® assays for those patients who have been referred to the walk-in clinic complaining of ‘dyspepsia’. This is a set of three assays (Pepsinogen I, Gastrin 17 and Helicobacter pylori) and the results use an algorithm which can provide information about the stomach health and about the function of the stomach mucosa. Results: Of all the samples tested 63.5% showed no abnormalities and were reported as ‘normal function of gastric mucosa.’ These patients would be classed as having functional dyspepsia. Thirty-six samples (19.9%) were positive for Helicobacter pylori and the remaining samples had a variety of abnormal results. Conclusion: Dyspepsia is a common problem seen both by primary care physicians and gastroenterologists. Using the results from the serological analysis of the patients’ serum the clinician can delineate between gastric atrophy and a normal health stomach usually without the need to refer the patient for endoscopy.

Clinical evaluation of a new multi-purpose disinfecting solution in symptomatic wearers of silicone hydrogel contact lenses

Correspondence: Renee Garofalo Alcon Research Ltd, 6201 South Freeway, TC-44, Fort Worth, TX 76134, USA Tel +1 817 615 2712 Fax +1 817 615 4602 Email renee.garofalo@alconlabs.com Background: The purpose of this study was to evaluate the safety and efficacy of a new multi-purpose disinfecting solution containing a diblock copolymer, poly(oxyethylene)poly(oxybutylene), designed to improve the wetting properties of silicone hydrogel lenses in patients with symptoms of discomfort. Methods: This 30-day, randomized, concurrently controlled, double-masked, multi-site study involved 589 subjects at 42 investigational sites in the US. Existing symptomatic lens wearers were randomly assigned to either regimen 1 (OPTI-FREE PureMoist, Alcon Laboratories Inc,) a newly developed formulation containing the diblock copolymer), or regimen 2 (renu freshTM multi-purpose solution Bausch + Lomb, Inc). On days 0, 14 and 30, subjects assessed acceptability and comfort using seven Likert-type questions, rated the intensity of ocular symptoms (comfort, dryness, irritation, scratchiness, burning, stinging) on a visual analog scale (0–100), as well as reported lens wearing time, comfortable lens wearing time, and rewetting drop frequency. The investigators assessed slitlamp findings (including circumlimbal conjunctival lissamine green staining and corneal fluorescein staining), on-eye lens surface wettability and deposits, visual acuity, and adverse events. Results: Differences favoring regimen 1 were noted on Day 30 for the primary Likert statement “I can comfortably wear my lenses” (P = 0.047) and for comfortable lens wear time (P = 0.041). Symptoms of ocular scratchiness, ocular burning, and ocular stinging were all rated lower after 30 days of use by subjects using regimen 1 compared with those using regimen 2 (P # 0.024). Circumlimbal conjunctival staining (sum score) was significantly lower with regimen 1 (P , 0.0001). Other parameters did not show any difference between the two treatment regimens. Conclusion: This study shows that the new multi-purpose disinfecting solution is safe and effective when used by symptomatic silicone hydrogel contact lens wearers. By improving symptoms of scratchiness, burning, stinging, and comfortable wear time, and decreasing circumlimbal conjunctival staining, the new multi-purpose disinfecting solution enhances the patient’s wearing experience and helps maintain optimal lens performance.

Tongue protectors for use in burning mouth syndrome?

Randomised controlled trial. Fifty patients (46 females, four males) aged 61.18 ± 12.27 years with a clinical history of continuous symptoms of oral burning or pain for more than six months, no clinical abnormalities that could account for the symptoms and normal blood test findings were allocated using computer randomisation to either the control group who were given information only, or to the experimental group that received the same information plus the tongue protector. The protector consisted of a transparent, low density polyethylene sheath covering the tongue from the tip to the posterior third. The trial length was two months. The primary outcome was oral symptoms as recorded using a visual analog scale (VAS) consisting of a 10cm vertical line marked from 0 (=no pain) to 10 (= most severe pain experienced). Secondary outcome was quality of life, measured using OHIP-49 and SF-36. Change in VAS was reported as mean (± s.d.). For the non-intervention group this was 1.4 (± 1.6). For the intervention group it was 3.6 (± 2.2). This difference was statistically significant (P<0.001). For the OHIP-49 the mean changes were 1.92 (± 4.93) and 18.44 (± 29.53) respectively, which was statistically significant (P=0.008). Three of the eight measures in the SF-36 showed a statistically significant improvement in the tongue protector group. Confidence intervals were not reported for any of the measures. Although a statistical significance was observed in the VAS, studies are needed to reproduce these findings in larger series, over longer periods of time and involving an adequate sample of patients.

Aetiology and therapeutics of burning mouth syndrome: an update

To provide a review on the aetiology and therapeutic options for the management of patients with burning mouth syndrome (BMS). BMS is a chronic disorder that frequently affects women and is characterised by burning symptoms of the oral mucosa without clinical signs. This syndrome has a complex and multifactorial characteristics, but its aetiology remains unknown and this makes it difficult with regard to the treatment and management of such patients. Despite not being accompanied by evident organic changes and not presenting risks to health, BMS can significantly reduce the quality of life for patients. The article reviews the literature regarding aetiologic factors, clinical implications and treatment of BMS. involvement of neurological, emotional and hormonal alterations is proposed in BMS aetiology. However the mechanisms of its development are complex and not completely understood. Tricyclic antidepressants, benzodiazepines and antipsychotic drugs are the most accepted options in treatment and show variable results. The correct diagnosis of BMS and the exclusion of possible local or systemic factors that can be associated with the symptoms are fundamental. It is also important to evaluate the quality of life for these patients to recognise the potential impact of this condition on their lives.

Failure Analysis of a Helicopter's Main Rotor Bearing

Presented results report some of the findings of a detailed failure analysis carried out on a main rotor hub assembly, which had symptoms of burning and mechanical damage. The analysis suggests environmental degradation of the grease which causes pitting on bearing-balls. The consequent inefficient lubrication raises the temperature which leads to the smearing of cage material (brass) on the bearing-balls and ultimately causes the failure. The analysis has been supported by the microstructural studies, thermal analysis and micro-hardness testing performed on the affected main rotor bearing parts.

The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia

To observe the therapeutic efficacy of Xiaopi-I on functional dyspepsia and its effects on gastric emptying. A total of 134 patients with functional dyspepsia were randomly assigned to 2 groups. The patients in the Xiaopi-I group (66 cases) and the Domperidone group (68 cases) were given Xiaopi-I granules and Domperidone 10 mg, 3 times a day, respectively. Another 20 healthy volunteers were chosen as the negative control group. The severity scores of the symptoms, as well as the gastric emptying, were detected before and after 4-week treatment by barium strip-trial meal. During therapy, 6 cases from the Xiaopi-I group and 8 cases from the Domperidone group were lost to follow, and 120 cases finally finished the study. Statistical differences were observed from both groups in terms of the symptoms of postprandial fullness early satiety, epigastric pain, and epigastric burning after 4-week treatment (P<0.01). The symptomatic severity scores of the Xiaopi-I group before and after the treatment were 7.48±1.64 and 2.16±1.26, respectively (P<0.01). Gastric emptying rates were also improved in the patients with delayed gastric emptying, and the effective rates were 91.3% and 75.8% in the Xiaopi-I and Domperidone groups, respectively. No obvious adverse effects were found from both groups. Xiaopi-I was an effective and safe agent in the treatment of functional dyspepsia and was worth of further development in clinical.

Fenómeno de Raynaud y el amamantamienteo doloroso

Raynauds phenomenon and pain during breastfeeding Raynauds phenomenon of the nipple is a pathology precipitated by exposure to cold and leads to intermittent vasospasm of arterioles, producing clinical symptoms of pain, burning and paresthesias. This condition is a treatable cause of painful breastfeeding that can affect up to 1 in 5 women of childbearing age. If misdiagnosed, it can occasionally lead to cessation of breastfeeding due to its uncomfortable symptomatology.

Chemotherapy-induced polyneuropathy. Part I. Pathophysiology [Polish version: Polineuropatia wywołana chemioterapią. Część I. Patofizjologia p. 79

Chemotherapy-induced peripheral neuropathy (CIPN) is a toxic neuropathy, a syndrome consisting of highly distressing symptoms of various degrees of severity. It includes numbness of distal extremities, long-term touch, heat, and cold dysaesthesia and, in more severe cases, motor impairment affecting daily functioning. Each form of the syndrome may be accompanied by symptoms of neuropathic stinging, burning, and tingling pain. In the case of most chemotherapeutic agents, the incidence and severity of CIPN are dependent on the cumulative dose of the drug. The syndrome described is caused by damage to the axons and/or cells of the peripheral nervous system.Chemotherapeutic agents have distinct mechanisms of action in both neoplastic tissue and the peripheral nervous system; therefore, CIPN should not be regarded as a homogeneous disease entity. The present article is an attempt to systematize the knowledge about the toxic effects of chemotherapy on the peripheral nervous system.

Clinical Outcome of Patients With Severe Burns Presenting to the Emergency Department

Background : Burns are a leading cause of morbidity and mortality worldwide. Although a local burn covering a limited surface area can heal readily, deep or extensive burns can result in systemic damage and even death. This study evaluated the clinical characteristics of the patients presenting with severe burns and investigated the factors influencing mortality. Methods: The data for 1003 patients who presented with symptoms of severe burn to a tertiary care university hospital in Turkey between 2006 and 2007 were evaluated retrospectively. Results: The overall patient mortality was 7.7% (n = 78). The effect of male gender and age on mortality was significant. The highest mortality rate was in the group aged > 40 years. A burned area larger than 21% of the body surface conferred a high risk of mortality. A hospital stay for longer than 10 days, the presence of delirium at the time of presentation, hyperuricemia, the need for debriding, grafting, or fasciotomy, sepsis, hypovolemic shock, and a positive blood culture were significant predictors of mortality. Conclusions : Severe burns have to be treated in a burn unit or burn center. As the prevention of burns is important, it is important to identify the region-specific causes of burns and the risk factors that influence mortality. doi:10.4021/jcs19e

Safety and outcome of surgical debridement of insertional Achilles tendinopathy using a transverse (Cincinnati) incision

This is a prospective analysis on 30 physically active individuals with a mean age of 48.9 years (35 to 64) with chronic insertional tendinopathy of the tendo Achillis. Using a transverse incision, the tendon was debrided and an osteotomy of the posterosuperior corner of the calcaneus was performed in all patients. At a minimum post-operative follow-up of three years, the Victorian Institute of Sports Assessment scale-Achilles tendon scores were significantly improved compared to the baseline status. In two patients a superficial infection of the wound developed which resolved on antibiotics. There were no other wound complications, no nerve related complications, and no secondary avulsions of the tendo Achillis. In all, 26 patients had returned to their pre-injury level of activity and the remaining four modified their sporting activity. At the last appointment, the mean pain threshold and the mean post-operative tenderness were also significantly improved from the baseline (p < 0.001). In patients with insertional tendo Achillis a transverse incision allows a wide exposure and adequate debridement of the tendo Achillis insertion, less soft-tissue injury from aggressive retraction and a safe osteotomy of the posterosuperior corner of the calcaneum.

Comparison of the Efficacy of Topical N-Acetyl-Cysteine and a Topical Steroid-Antibiotic Combination Therapy in the Treatment of Meibomian Gland Dysfunction

This study aimed to compare the efficacy of topical N-acetyl-cysteine (NAC) with a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with meibomian gland dysfunction (MGD). Twenty patients with MGD were prospectively randomized and assigned into 2 groups. The patients were instructed to use either NAC 5% or a topical steroid-antibiotic combination, betamethasone 0.1%-sulfacetamide sodium 10%, topically 4 times a day for a month. All patients were instructed to apply lid hygiene once daily. One month of topical therapy provided statistically significant improvements in fluorescein break-up time and Schirmer scores as compared with the initial study visit in both groups (P≤0.001). Significant improvements for the symptoms of ocular burning, itching, and intermittent filmy or blurred vision were noted in both groups at 1 month as compared with 1 day (P<0.05). Considering these rates, there was no significant difference between the groups (P>0.05). None of the patients developed an allergic reaction to the medications, and intraocular pressure measurements were within the normal limits in both groups. When used in conjunction with eyelid hygiene, topical administration of NAC appears to be as effective as a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with MGD.

The Dubious Effect of Milnacipran for the Treatment of Burning Mouth Syndrome

Burning mouth syndrome (BMS) is a condition accompanied by oral burning symptoms, including glossal pain (glossodynia) without a detectable cause. Although BMS is a chronic-pain syndrome, only one self-controlled pilot study and some case reports have reported that milnacipran is effective for the treatment of chronic pain, including that caused by BMS. However, these papers assessed only pain, and the dosage of prescribed milnacipran varied from 30 to 150 mg/d in each patient. In this study, the dosage of prescribed milnacipran was set at 60 mg/d for 12 weeks for all patients, and depression and quality of life (QOL) were assessed in addition to pain. Twelve patients with glossodynia participated in this study. Milnacipran was initiated at a dosage of 15 mg/d and then raised gradually to 60 mg/d after 4 weeks of treatment; this dose was continued until the end of the study (total of 12 weeks). The evaluation included the Hamilton Rating Scale for Depression, the Visual Analog Scale score for pain evaluation, the General Oral Health Assessment Index for oral-related QOL evaluation, and the Medical Outcomes Study's 36-Item Short-Form Health Survey (SF-36) for whole QOL evaluation. The Hamilton Rating Scale for Depression score decreased significantly after treatment with a 60-mg/d dosage of milnacipran for 12 weeks. However, the Visual Analog Scale pain, General Oral Health Assessment Index, and SF-36 scores did not change. A randomized, double-blind, placebo-controlled multi-institution trial of milnacipran will be essential to determine its effectiveness for the treatment of BMS.

시설재배 부추 잎끝마름증 발생에 영향을 미치는 토양특성

시설재배 부추의 잎끝마름증상 발생에 영향을 미치는 인자를 구명하기 위하여 포항지역 부추 재배지 토양 132 개소의 토양특성을 분석하였고 통계적 방법으로 관련인자를 조사한 결과, pH는 7.0, 유기물함량 <TEX>$41g\;kg^{-1}$</TEX>로 적정 범위에 비해 높은 편이었으며 점토함량이 많은 식질토양인 Alfisols에서 pH, 치환성 양이온, 전기전도도, 질산태 질소함량이 높았고 잎끝마름증 발생비율이 높았으며 pH와 치환성 칼슘함량과 매우 높은 연관성을 나타내었다. pH가 높고 암모니아태 질소함량이 높을수록 암모니아 가스의 생성이 증가하였으며, 질산태질소와 토양유기물은 암모니아 가스 생성에 직접적인 영향은 없으나 토양의 pH 변화에 따라 질산태질소의 암모니아태 질소로 환원 및 유기태질소의 무기화에 따른 암모니아태 질소의 농도변화에 영향을 미치는 것으로 나타났다. 부추의 잎끝마름증은 토양 pH 변화에 따른 무기태질소의 환원에 따른 암모니아 가스생성에 따른 것으로 사료된다. Tip burn has been reported as one of the most serious physiological disorder in Chinese chives (Allium tuberosum Rottl.) cultivated in plastic film house. In this study, a physiography and chemical properties of 132 plastic film house soils were investigated to elucidate factors affecting tip burn symptom. Also influence of soil properties on tip burn was statistically determined by path analysis and association analysis including a chi-square test or logistics analysis. Probability distribution of inorganic aqueous species, such as ammonia (g) was calculated using MINTEQ program. Soil order and chemical properties, especially pH, exchangeable calcium and inorganic nitrogen, showed a significant relationship with tip burn of Chinese chives. Tip burn symptoms occur mainly in an alkaline soil classified as Alfisols. Result of linear regression and path analysis exhibited that formation of ammonia (g) from soil solution depend upon soil pH and were associated with ammonium resulting from soil organic matter or nitrate. These results indicate that tip burn symptom of Chinese chives is directly affected by ammonia gas originated from alkaline soil condition.

Role of contact lenses in relieving ocular allergy

To examine the potential barrier and lubricating effects of modern daily disposable contact lenses (DD) against airborne antigens. Ten patients with skin prick and ocular conjunctival provocation confirmed allergic sensitivity to grass pollen were recruited (average age 27.4 ± 7.7 years). Each had their ocular symptoms (on a 0 none to 5 extreme scale) and appearance of bulbar and limbal conjunctival redness, palpebral conjunctival redness and roughness, and corneal and conjunctival fluorescein staining (CCLRU scale) graded before and five minutes after exposure to 400 grains grass pollen/m(3) for 2 min in a purpose-designed exposure chamber to simulate the conditions of a 'very high' pollen-count day. This was repeated on three occasions separated by >72 h wearing etafilcon A (sDD), nelfilcon A with enhanced lubricating agents (ELDD) and no contact lenses in random order out of the pollen season. Each sign and symptom was compared to baseline for each condition. The duration of the symptoms was also recorded (http://www.clinicaltrials.govNCT01125540). Only symptoms of burning and stinging were significantly reduced in severity by ELDD (Chi-Sq = 7.6, p = 0.02), but overall symptoms were significantly reduced in duration (F = 3.60, p = 0.05). Bulbar hyperaemia, corneal and conjunctival staining, and palpebral conjunctival roughness were significantly reduced by DD wear (p < 0.01), with limbal and palpebral conjunctival redness further reduced in ELDD (p < 0.05). Daily disposable contact lenses offer a barrier to airborne antigen which is enhanced by modern lenses with enhanced lubricating agents.

Clinical approach to the treatment of painful diabetic neuropathy

Painful neuropathy is a common and often progressive complication of diabetes. Patients frequently report symptoms of tingling, burning, lancinating pain, hyperesthesia and allodynia. The natural history of the disease may vary from intermittent mild symptoms to severe chronic daily pain; the latter is often associated with diminished quality of life. There are a variety of pharmaceutical agents from different medicinal categories available for the symptomatic treatment of painful diabetic neuropathy, however selecting an agent is often challenging given the breadth of choices and lack of consistent guidelines. As a result, many patients remain untreated or undertreated.This article presents a practical clinical approach to the treatment of pain in diabetic neuropathy. Recommendations for first, second and third line medications are based on specific evidence for the treatment of painful diabetic neuropathy as well as safety, tolerability, drug interactions and cost. Additional topics of discussion include breakthrough pain, opioid use and topical therapies. This review does not comprehensively discuss all possible treatments for painful neuropathy, but provides a systematic approach designed to guide clinicians in tailoring therapies to the individual patient.

Efficacy of Hydroxypropyl Cellulose Ophthalmic Inserts (LACRISERT) in Subsets of Patients With Dry Eye Syndrome: Findings From a Patient Registry

To determine acceptability and efficacy of hydroxypropyl cellulose ophthalmic inserts in patients with dry eye syndrome (DES) and additional comorbidities. A multicenter, 2-visit, open-label, 4-week registry study. Five hundred twenty patients were recruited to the intent-to-treat group. Four hundred eighteen patients completed the study including 86 contact lens wearers, 79 with cataract diagnosis, 52 with prior cataract surgery, 22 with prior laser-assisted in situ keratomileusis, and 15 with glaucoma. Patient questionnaires were completed at baseline and after 4 weeks of treatment to assess mean change in severity of DES symptoms, ocular surface disease index (OSDI) scores, frequency of occurrence of DES symptoms, occurrence of difficulty when performing activities of daily living (ADLs), and frequency of discomfort in various environmental conditions. Mean change was measured from visit 1 to visit 2. Symptoms, OSDI scores, and measure of degree of difficulty when performing ADLs. Four hundred eighteen patients completed the study. Compared with baseline, this population of patients demonstrated statistically significant improvements in mean OSDI scores (P = 0.0215) and symptoms of discomfort, burning, dryness, grittiness, stinging, and light sensitivity (P < 0.05). Mean improvement in OSDI scores of patients in the 5 identified subsets of patients with comorbid conditions were significant for patients using contact lenses (P < 0.025), who had undergone prior cataract surgery (P < 0.04), and with prior laser-assisted in situ keratomileusis surgery (P < 0.05). Patients diagnosed with cataracts or glaucoma did not show significant changes in any measures in this study. Patients with DES and comorbid conditions experienced relief of symptoms and benefit to ADLs and quality of life similar to patients without comorbid conditions. In subsets of patients with moderate to severe DES and comorbid conditions, hydroxypropyl cellulose ophthalmic inserts improve the symptoms of DES, ability to perform ADLs, and quality of life. The reported benefits may be additive to those seen with patients' existing therapies.