A design methodology for creating a set of high-voltage gain DC–DC converters is presented and discussed in this article. The proposed generation is based on ladder switched capacitor (SC) with coupled inductor. So, eight high-voltage converters with a single switch without increasing the number of components are proposed. Detailed evaluations about the derivation of each topology, comparative analysis among main features of each converter are presented. These converters are evaluated in different aspects, such as principle of operation, voltage gain, sensibility of the output voltage, total voltage stress (TVS), total current stress (TCS), ZCS, charging mode compared to the standard SCs cells, design guidelines, power density, power losses, and estimated efficiency. By these comparisons, the main feature and limitations of the analyzed converters are recognized. Thus, four topologies were chosen to be evaluated experimentally, considering 200 W, 30 V, 400 V, and 50 kHz. The combination of the techniques provides the best trend off on the comparative analysis carried out in this work. The results show that attention should be paid to choosing the best position to include a technique. In this case, the best choice was BCISC-V converter, which presented the best voltage gain, TCS, ZCS, and efficiency characteristics.