In this article, the heat transfer is examined in spinning flow of the Casson nanofluid. The spinning motion is produced with the help of stretching and rotating cylinder. In current work two cases, both for constant and variant axial temperature over the exterior of the spinning cylinder are studied. For controlling the rate of heat transfer, some heat effects such as heat generation/absorption, Joule heating and thermal radiations have been considered for flow system. For investigation the influence of thermophoretic force and Brownian motion exerted by Casson nanofluid, the famous Buongiorno model has been employed. The modeled equations have converted to dimensionless form using a set of similar variables. To improve the solution convergence of flow equations a compressed variable is also employed. As the main outcome of this work, it has observed that, with growing values of Reynolds number and magnetic parameter the flow characteristics reduce in all directions. A growth in temperature profile is also observed for constant wall temperature (CWT), while a reduction is noticed in temperature profile for prescribed surface temperature (PST). Moreover, the concentration of fluid reduces with growing values of Prandtl and Lewis numbers.