Event Abstract Back to Event Psychomotor development of exposed mice offspring to fenugreek seeds L. Khalki1*, Z. Sokar1 and S. B. M'hamed1 1 University Cadi Ayyad, Laboratory of Pharmacology, Neurobiology and Behavior,Faculty of science, Semlalia, Morocco It is recognized that some medicinal plants have harmful effects on maternal and fetal health. However, most clinical claims of medicinal plants, made available, to consumers do not have any scientific data support. The present study was undertaken to evaluate the prenatal effects of butanol extract from deeds of fenugreek on neurodevelopment behavior in mice. The effect of prenatal exposure to fenugreek seeds extract on behavioral motor skills parameters in Swiss mice offspring was assessed. Pregnant mice were treated by gavages with 300 mg / kg / day of a butanolic extract dissolved in saline solution throughout the gestational period. Control animals received the vehicle for the same period. Before weaning, the pops were examined using the swimming behavior (PND10, 12 and 14) and the cliff avoidance test (PND 6). In the treated offspring, swimming angle was significantly lower in scores than controls. Cliff avoidance test was significantly affected in treated group compared to controls. These results showed a delay of early response development and motor coordination in the offspring of mice exposed to fenugreek seeds butanolic extract during all pregnancy period. We concluded that the fenugreek seeds consumption during pregnancy could be a cause of offspring developmental toxicity. Conference: 2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010. Presentation Type: Poster Presentation Topic: Poster session 1: Neurodegenerative diseases Citation: Khalki L, Sokar Z and M'hamed SB (2010). Psychomotor development of exposed mice offspring to fenugreek seeds. Front. Neurosci. Conference Abstract: 2nd NEUROMED Workshop. doi: 10.3389/conf.fnins.2010.12.00010 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Jun 2010; Published Online: 03 Jun 2010. * Correspondence: L. Khalki, University Cadi Ayyad, Laboratory of Pharmacology, Neurobiology and Behavior,Faculty of science, Semlalia, Marrakesh, Morocco, bamhamed@ucam.ac.ma Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers L. Khalki Z. Sokar S. B M'hamed Google L. Khalki Z. Sokar S. B M'hamed Google Scholar L. Khalki Z. Sokar S. B M'hamed PubMed L. Khalki Z. Sokar S. B M'hamed Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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