ABSTRACT Background Although the incidence of gastric cancer has declined in the general population, it is the second most frequent cancer in Uzbekistan with its incidence in the elderly increasing as a result of increased life expectancy. This present study tried to determine the role of age on outcomes of surgical treatment for gastric cancer in Uzbek population. Methods The study reviewed 288 patients who underwent gasterectomy for locally advanced gastric cancer. The clinicopathological features of elderly patients (≥75 years, n = 167) and younger patients ( Results Distinct characteristics of elderly patients included more frequent underlying disease, deeper invasion, and more frequent lymph node metastasis. The postoperative morbidity and mortality rate did not differ between the two groups. Age, preoperative performance status, preoperative transfusion, and presence of comorbidity were not independent predictors of postoperative complications. However, the extent of gastric resection and combined resection were closely related to postoperative complications in patients with non-curative gastrectomy. Conclusion Analysis the direct results of surgical treatment of elderly gastric cancer patients shows that, age is not a limiting factor for performing curative surgery. However, the risk of postoperative morbidity should be considered carefully in total gastrectomy and combined resection. Disclosure All authors have declared no conflicts of interest.