An Automated Storage and Retrieval System (AS/RS) is one of modern technologies in warehouse operation. Despite many advantages offered by AS/RS such as improving accuracy, efficiency, and safety, AS/RS operation is very complex started from strategical, tactical, to operational level. Reaching optimal combination for all decisions become important. However, due to the dynamic and combinatorial complexity as well as uncertainty in supply – demand, it cannot be solved through the general mathematical optimization. Therefore, this study introduces simulation–optimization (SO) framework for integrated AS/RS planning considering 7 decisions at a time. Furthermore, a comprehensive mathematical model for measuring AS/RS energy consumption is formulated. The proposed framework is implemented in the China’s warehouse company for optimizing multi-objective namely energy consumption and travel time per unit. Non-dominated Sorting Genetic Algorithm II (NSGA-II) is developed as metaheuristics algorithm and discrete-event simulation is modeled based on FlexSim. The results produce non-dominated solutions that are further summarized through clustering algorithm resulting in 4 different clusters with significantly different impacts. This study provides insightful analysis and managerial implications for reaching near-global optimum in AS/RS planning towards green operation.