Currently, sunflower is the main oil crop in the Tambov region. The most important task of modern agricultural production is the use of technologies that increase the yield and quality of field crops. Data on seed and oil yield of sunflower are very important when choosing different types of mineral fertilizers. In this regard, the purpose of our research was to study the effect of various doses, methods and terms of application of macro- and microfertilizers on yield, crop quality and oil yield of sunflower in a link of the 6-year crop rotation: fallow – winter wheat – corn (for grain) – barley – sunflower – spring wheat. The research was conducted at the Tambov Research Institute of Agriculture – a branch of the I.V. Michurin Federal Research Center, which is located in the Tambov region. On typical black soil, application of both traditional mineral fertilizers (N16P16K16) for plowing, and liquid mineral fertilizers (Megamix) during pre-sowing treatment and for plants treatment during vegetative period contributes to obtaining an additional seed and oil yields. For 2014–2020, the highest seed and oil yields were obtained in variant (5) with N30P30K30 for plowing + seed treatment with Megamix (2.0 l/t) and amounted to 2.84 t/ha and 1324 kg/ha, respectively. The fat content varied depending on the variant of the experiment. The maximum indicator of 53.6% was in the variant with the application of N30P30K30. But due to the lower seed yield, the oil yield amounted to 1.21 t/ha. All variants for seed and oil yields were superior to the control one (without fertilizers).