Sugar Levels Research Articles

Dyslipidemia and hyperglycemia induce overexpression of Syndecan-3 in erythrocytes and modulate erythrocyte adhesion.

Erythrocytes are important vascular components that play vital roles in maintaining vascular homeostasis, in addition to carrying oxygen. Previously, we reported that the changes in the internal milieu (e.g. hyperglycemia or hypercholesterolemia) increase erythrocyte adhesion to various extracellular matrix components, potentially through altering glycosaminoglycans (GAGs). In this study, we have investigated the expression of syndecan (Sdc) family members that could be involved in mediating cytoadherence under conditions of dyslipidemia and hyperglycemia. Among the Sdc family members analysed, we found significant overexpression of Sdc-3 in erythrocyte membranes harvested from high-fat-fed control and diabetic animals. Animal studies revealed a positive correlation between Sdc-3 expression, blood sugar levels and erythrocyte adhesion. In the human study, diabetic cohorts with body mass index >24.9 showed significantly increased expression of Sdc-3. Interestingly, blocking the Sdc-3 moiety with an anti-Sdc-3 antibody revealed that the core protein might not be directly involved in erythrocyte adhesion to fibronectin despite the GAGs bringing about adhesion. Lastly, Nano liquid chromatography-mass spectrometry/MS verified the presence of Sdc-3 in erythrocyte membranes. In conclusion, the high-fat diet and diabetes modulated Sdc-3 expression in the erythrocyte membrane, which may alter its adhesive properties and promote vascular complications.

Directly Acting Anti-Viral Drugs and Its Metabolic Side Effects in Patients with Chronic HCV

Abstract Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, with an estimated 170 million people infected worldwide. Treatment of hepatitis C virus has traditionally been difficult because of low rates of treatment success and high rates of treatment discontinuation due to side effects. Aim of the Work The aim of this work is to study side effects of directly acting anti HCV drug (DAA) and its progression in metabolism of lipid profile, blood sugar level, and renal function. Patients and Methods This case study had been carried out on 200 subjects presented to Department of Internal Medicine at Kobbri ELkobba hospital inpatient and outpatient clinics between March 2016 and September 2016. Results sustained virological response (12 weeks) after end of the treatment in more than 90% of patients, Liver function parameters including albumin, bilirubin, and prothrombin time and liver enzymes Ast, Alt improved in the majority of patients during and after the end of therapy,but there is significant increase in urea level, serum creatinin and HbA1C. There is significant decrease in LDL and mild increase in TG level. Conclusion Once-daily oral daclatasvir plus sofosbuvir with or without Ribavirin was associated with high rates of sustained virologic response among patients infected with HCV, including chronic cirrhotic patients and relapsers, successful treatment associated with Improvement of liver function parameters in the majority of patients, Increase in urea level, serum creatinin and HbA1C. There is significant decrease in LDL and mild increase in TG level.

Correlation between Glycated Hemoglobin, Extra cranial Carotid Artery Disease, Peripheral Arterial Disease in Type ll Diabetic Patients with Coronary Artery Disease

Abstract Background Diabetes mellitus (DM) is the most common endocrine disorder where the body does not either produce enough insulin or has a resistance to the circulating insulin, and is characterized by high blood sugar levels over prolonged periods. DM is a growing global health issue. In 2000, DM affected an estimated 171 million people in the whole world increased on 2011 to more than 366 million people and expected to be more than 552 million by 2030. Aim of the Work to correlate between HBA1C, carotid, peripheral and coronary artery disease in type II DM patients. Patients and Methods This is an observational study conducted at the coronary care unit & coronary catheterization lab unit of National Institute of Diabetes and Endocrinology, Egypt. Its aim was to correlate between HBA1C, carotid, peripheral and coronary artery disease in type II DM patients. 122 patients with eligible criteria were recruited to the study after signing consent. A full history was taken from every patient, a full clinical examination, 12 lead-ECG, Echocardiography, Carotid duplex, ABI measurement, HbA1C and Invasive non emergent coronary angiography were done. Results Data was collected, tabulated, and analyzed, which revealed that carotid IMT in patients with HbA1C >7% was significantly higher than those with HbA1C<7, HbA1C had a significant positive correlation with carotid IMT, ABI was significantly lower in patients with HbA1C>7% compared to those with HbA1C<7%, ABI had a significant negative correlation with carotid IMT, Number of diseased coronary vessels was significantly higher in patients with higher HbA1C >7% compared to those with HbA1C>7%, ABI had a significant negative correlation with number of diseased coronary vessels and IMT had a significant positive correlation with number of diseased coronary vessels in patients with higher HbA1C >7% with no significant correlation in those with HbA1C<7%, HbA1C can significantly predict peripheral artery disease and carotid atherosclerosis. Conclusion HbA1C correlates significantly with Carotid atherosclerosis, PAD and CAD severity based on number of diseased coronary vessels in uncontrolled TIIDM patients. Also, PAD and carotid atherosclerosis correlate significantly with CAD severity based on number of diseased coronary vessels in uncontrolled TIIDM patients. Also, PAD correlates significantly with carotid atherosclerosis in uncontrolled TIIDM patients. HbA1C can significantly predict carotid artery disease and PAD.

Effect of hyperbaric oxygen therapy on diabetes- related oral complications

ABSTRACT Altun BD, Sümen SG, Öçbe M, Dumlu A. Effect of hyperbaric oxygen therapy on diabetes-related oral complications. Undersea Hyperb Med. 2024 Second Quarter; 51(2):101-106. Background: Diabetes Mellitus is a chronic disease characterized by uncontrolled blood sugar levels, which lead to end-organ damage. While the diagnosis and treatment of its complications have been extensively studied, the effect of Hyperbaric Oxygen Therapy (HBO2) on diabetes-related oral complications remains unexplored. Aim: This prospective clinical study aims to investigate the effect of HBO2 on diabetes-related oral complications. Methods: Twenty patients diagnosed with diabetic foot ulcers and scheduled for HBO2 were included in this study. We recorded stimulated and unstimulated saliva pH, buffering capacity, flow rate, and subjective symptoms such as dry mouth, halitosis, taste loss, difficulty swallowing, and clinical examination findings before HBO2 and after the 21st session. Results: Upon comparing the findings, we observed a significant decrease in dry mouth and halitosis, periodontal disease severity, and healing of candida-related stomatitis and angular cheilitis. Despite not reaching statistical significance for other saliva parameters, the unstimulated salivary flow rate increased to normal limits (0.3-0.4 ml/min) in 6 out of 8 patients with a flow rate of less than 0.25 ml/min. Conclusion: Our study investigated the effect of HBO2 on diabetes-related oral complications for the first time, highlighting symptomatic relief for dry mouth and halitosis. Although our results are insufficient to report a definitive benefit, they underscore the need for further research on the oral health effects of HBO2.

Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols

ABSTRACT Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols.

Physical exercise as a key element in the behavioral treatment of type 2 diabetes - the extent to which patients follow recommendations

Introduction and purpose Diabetes is a set of metabolic disorders whose common, characteristic feature is the occurrence of hyperglycemia. Elevated glycemia levels result from impaired insulin secretion and/or defects in its action. In type 2 diabetes, we have modified risk factors such as improper diet, reduced physical activity, and obesity. In the context of these reversible factors, intervention in patients' lifestyle, with particular emphasis on physical activity, seems advisable. To investigate the implementation of recommendations for the treatment of type 2 diabetes, relating to physical activity as a component of behavioral treatment of diabetes. Materials and methods. Author's survey covering patients' knowledge about their disease, needs and expectations regarding education. The questionnaire examines the physical activity of patients newly diagnosed and already treated for type 2 diabetes. Results. The most frequently undertaken exercise was of medium intensity in the form of walking or "Nordic walking". This was also more likely to be intensified. Patients choosing this type of activity practiced it much more often and more regularly than other types of activity. Running and cycling were other activities undertaken by the patients, although in the younger group of patients. Patients who enjoyed physical exercise were more likely and willing to do it and it was more regular. Conclusions. Patients were reluctant to undertake physical exercise and usually did not treat it as an integral part of treatment. Usually, it was not a very intense effort. They also rarely intensified it when the diagnosis was made. Most of the respondents did not understand the role of exercise in the treatment process and its impact on sugar levels.

Network analysis of negative emotions in patients with episodic migraine: need for a multidisciplinary perspective.

Episodic migraine (EM) is the second most prevalent neurological disorder worldwide and is responsible for more disability than all other neurological disorders combined. Triggers for the development of migraine include, stress, emotional burden, low blood sugar levels, tobacco, skipped meals, anxious and depressive feelings. Migraine affects both children and adults, occurring three times more frequently in women than in men. The aim of this study was to evaluate the psychological profile of EM patients and the relationship among negative emotions in EM patients, analyzing self-efficacy measures in pain management. We performed an observational study in 60 outpatients aged 18-55 years (mean age 33.8; SD ±10.4) with EM. All patients have been enrolled at the Headache Center of the San Salvatore Hospital of L'Aquila. The assessment comprised five standardized psychological self-assessments investigating relevant emotional dimensions and pain self-efficacy, along with two questionnaires assessing migraine-related disability. A network analysis of negative emotions was performed to evaluate which emotional traits and relationships play a crucial role in pain coping and management. Our findings indicate that migraine significantly impairs the quality of life of patients in their daily lives. Over half of the patients reported experiencing severe disability, with negative emotions significantly influencing their ability to cope with pain and maintain productivity during migraine attacks. Dysphoric variables (irritability, interpersonal resentment, and surrender) were correlated with difficulties in emotion regulation ability and with the capacity of engaging in goal-directed behaviors despite experiencing pain. The ability to regulate one's emotions and manage dysphoria were positively correlated with pain self-efficacy, whereas positive mental health was associated with individuals' confidence in performing activities despite experiencing pain. Negative emotions had a negative correlation with positive mental health and were linked to a lower capacity to carry out daily activities despite experiencing migraine pain. This suggests that psychological interventions could improve mental health and potentially surpassing the effects of pharmacological interventions alone in migraine management. An integrated, patient-centered approach may represent an effective paradigm to address and reduce the burden of migraine, leading to a reduction in healthcare costs.

From pathophysiology to personalized care: A comprehensive review of diabetic kidney disease

Diabetic kidney disease (DKD) stands as a prevalent and significant complication in individuals with type 2 diabetes, impacting nearly half of this population. It holds the primary position as the cause of chronic kidney disease and end-stage kidney disease globally, associated with heightened cardiovascular morbidity and mortality. Despite the array of available interventions to prevent and manage DKD, such as regulating blood sugar levels, controlling blood pressure, and inhibiting the renin-angiotensin system, numerous patients continue to grapple with the ongoing decline in kidney function and unfavorable outcomes. This comprehensive review offers an updated exploration of the pathophysiology, diagnosis, prevention, and treatment of DKD. Special attention is devoted to emerging treatment modalities displaying promising outcomes in clinical trials, notably sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, non-steroidal mineralocorticoid receptor antagonists, and innovative agents addressing inflammation and fibrosis. The discourse also delves into the complexities and opportunities associated with integrating these therapies into clinical practice, emphasizing the necessity for personalized and all-encompassing care for DKD patients. The conclusion outlines future directions, urging further research and providing recommendations to advance both understanding and practical approaches in this domain. Keywords: pathophysiology; personalized care; diabetic kidney disease

The Effect of a Vegan Diet on the Health Indicators and Outcomes of P atients with Type 2 Diabetes Mellitus.

Recently, there has been a notable increase in interest in various forms of vegetarianism, which may be due to the growing prevalence of health issues, such as Type 2 Diabetes Mellitus (T2DM). Adhering to a vegan diet may have positive health outcomes. As a result, we conducted a review article to gather data from previous research studies on the effects of a vegan diet on different aspects of managing patients with T2DM. We searched the PubMed website for research studies on how a vegan diet affects the outcomes of patients with T2DM. The research studies were categorized according to the type of data collected, such as prevalence, incidence, body weight, insulin resistance, glycemic control, and lipid profile. It was found that following a vegetarian diet can significantly reduce the risk of mortality from heart disease. Additionally, studies have demonstrated that a vegetarian diet is linked to several improvements in T2DM. However, long-term weight loss plans and managing T2DM is a comprehensive intervention that includes caloric restriction, exercise, and behavioral modification. Incorporating a vegan diet can be a valuable factor to consider in managing T2DM, as it can offer numerous benefits, such as increased insulin sensitivity, weight loss, and reduced blood sugar levels. It helps to reduce cholesterol levels, LDL, and triglyceride levels, which are all risk factors associated with T2DM. By reducing these risk factors, the vegan diet can improve the overall health of T2DM patients. </p>.

A deep neural network prediction method for diabetes based on Kendall's correlation coefficient and attention mechanism.

Diabetes is a chronic disease, which is characterized by abnormally high blood sugar levels. It may affect various organs and tissues, and even lead to life-threatening complications. Accurate prediction of diabetes can significantly reduce its incidence. However, the current prediction methods struggle to accurately capture the essential characteristics of nonlinear data, and the black-box nature of these methods hampers its clinical application. To address these challenges, we propose KCCAM_DNN, a diabetes prediction method that integrates Kendall's correlation coefficient and an attention mechanism within a deep neural network. In the KCCAM_DNN, Kendall's correlation coefficient is initially employed for feature selection, which effectively filters out key features influencing diabetes prediction. For missing values in the data, polynomial regression is utilized for imputation, ensuring data completeness. Subsequently, we construct a deep neural network (KCCAM_DNN) based on the self-attention mechanism, which assigns greater weight to crucial features affecting diabetes and enhances the model's predictive performance. Finally, we employ the SHAP model to analyze the impact of each feature on diabetes prediction, augmenting the model's interpretability. Experimental results show that KCCAM_DNN exhibits superior performance on both PIMA Indian and LMCH diabetes datasets, achieving test accuracies of 99.090% and 99.333%, respectively, approximately 2% higher than the best existing method. These results suggest that KCCAM_DNN is proficient in diabetes prediction, providing a foundation for informed decision-making in the diagnosis and prevention of diabetes.

Variation in Leaf Biochemical Compositon of Guava (Psidium guajava L) Hybrids

Interplay of several internal development cues leads to floral induction in perennials like guava, mango and litchi. The transition of plants from the vegetative to the reproductive phase depends on the biochemical composition of the leaves. In view of this, the present study was conducted to know the variation in biochemical composition in non-flowering and flowering guava plants. Seven guava hybrids H1 (ARP selection x Lalit), H2 (Lalit x ARP selection), H3 (Allahabad Safeda x ARP selection), H4 (Lalit x Allahabad Safeda), H5 (Allahabad Safeda x Lalit), H6 (Nagpur Seedless x Allahabad Safeda) and OP (Open pollinated progeny of Allahabad Safeda).) were used for estimation of biochemical constituents in blooming and non-blooming plants. Results revealed that higher levels of total sugars, protein, and carbohydrates were observed in the leaves of non-blooming plants compared to blooming plants. However, compared to non-flowered plants, flowering plants had leaves with a higher amount of total phenol.

The distribution of rainfall in areas suitable for sugarcane farming in Blitar Regency, East Java

Abstract Expansion of sugarcane in East Java continue to be implemented in addition to intensification to increase sugarcane production in East Java, including expansion to Blitar Regency. This study aims to determine the rainfall distribution in areas suitable for sugarcane cultivation in Blitar Regency, East Java. This study was done in 2022 by combining a sugarcane land suitability map in Blitar Regency from the Indonesian Center for Agricultural Land Resources Research and Development and an annual isohyet map. Maps showing the rainfall distribution that the further north in Blitar the more elevation and rainfall and decreasing to the south. Annual rainfall distribution of 1500-2000 mm and 2000-2500 mm in the areas of moderately and marginally suitable for sugarcane covered total area of 25,918.59 ha and 22,689.90 ha or 15.83% and 13.86% of the total existing land area, respectively. When expanding sugarcane development, it is essential to consider the rainfall distribution along with the spatial distribution of land. Therefore, field trials are needed in each zoning to determine the productivity level of sugarcane and sugar. Complementing the spatial distribution of land for sugarcane with the rainfall distribution in each zone is important to identify yield potential for each suitability class.

Incidence and predictors of new-onset atrial fibrillation in ST-elevation myocardial infarction: A single-center study.

Atrial fibrillation (AF) is a common arrhythmia that occurs following ST-elevation myocardial infarction (STEMI) and can significantly impact clinical outcomes. We investigated the incidence and predictors of AF following STEMI in patients, as well as its association with major adverse cardiac and cerebrovascular events (MACCE). We conducted a retrospective cohort study, including all STEMI patients who presented under code 247 to Tehran Heart Center between 2016 and 2020 and completed a 1-year follow-up. Patients were divided into two groups based on the development of AF during follow-up, and their baseline and clinical characteristics were compared. We used multivariable regression models to identify predictors of MACCE. Out of 3647 STEMI patients, 84 (2.3%) developed new-onset AF (NOAF). Patients with AF were significantly older and had lower levels of total and low-density lipoprotein cholesterol, triglyceride, and hemoglobin, but higher levels of fasting blood sugar and creatinine. AF patients were also more likely to have a history of hypertension, chronic kidney disease (CKD), congestive heart failure, and cerebrovascular accidents. The multivariable logistic regression model identified the CHA2DS2-VASc score and CKD as independent predictors of NOAF following primary percutaneous coronary intervention. Furthermore, the incidence of MACCE was higher in the AF group, and AF independently predicted MACCE with a hazard ratio of 2.766. The CHA2DS2-VASc score and the presence of CKD can serve as useful predictors of NOAF among patients with STEMI. Early detection and appropriate management are crucial to improve outcomes.

Association of Testosterone Level and Anti-SARS-CoV-2 Antibodies in Diabetic Patients in Babylon, Iraq

Abstract Background: The risk of developing a more aggressive disease condition is influenced by age and the presence of comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases. Diabetics may experience late diabetes complications such as diabetic renal disease and ischemic heart disease, which can make them frailer and exacerbate the severity of viral infections such as COVID-19 disease, which can result in kidney or heart failure. Objectives: To evaluate the levels of testosterone hormone in association with glucose levels in the diabetic population, choosing (50) diabetic patients with no known history of COVID-19 infection or receiving a COVID-19 vaccine were enrolled in the study. Materials and Methods: The anti-SARS-CoV-2 antibody was assessed for all patients and in 40 healthy individuals (control group). The study was carried out from January to May 2023 in Marjan Medical City and a private clinical laboratory. Testosterone levels and anti-SARS-CoV-2 antibodies were measured using manual principles and the methods of the Automated Fluorescent Immunoassay System. Fine care for the detection of HBA1C and Fuji film for RBS. Results: The results showed that reduced testosterone hormone level is associated with increased HBA1C and blood glucose levels, as well as anti-CoV-2–IgG antibodies. There is a negative (indirect) correlation between HBA1C and testosterone hormone, in contrast to a positive correlation with anti-SARS-CoV-2–IgG antibodies. Conclusion: Reduced testosterone hormone levels might indicate a more complicated prognosis of diabetes and in another way might be used as a treatment modality to regulate blood sugar levels after increasing its expression.

Review on Nutritional Potential of Underutilized Millets as a Miracle Grain.

The current situation, which includes changes in eating habits, an increasing population, and the unrestricted use of natural resources, has resulted in a lack of resources that could be used to provide nourishing food to everyone. Natural plant resources are quickly being depleted, so it is necessary to consider new alternatives. In addition to the staple grains of rice and wheat, many other crops are being consumed that need to be utilized to their full potential and have the potential to replace the staple crops. Millets are one of the most important underutilized crops that have the potential to be used as a nutricereal. Millets have a high nutritional value, do not produce acids, do not contain gluten, and can contribute to a healthy diet. Due to a lack of awareness regarding the nutritional value of millets, their consumption is still restricted to the population that adheres to conventional diets and is economically disadvantaged even though millets contain a significant amount of nutrients. Millets are becoming increasingly unpopular due to a lack of processing technologies, food subsidies, and the inconvenience of preparing food with millets. Millets are a Nutricereal rich in carbohydrates, dietary fibers, energy, essential fatty acids, proteins, vitamin B, and minerals such as calcium, iron, magnesium, potassium, and zinc. These nutrients help to protect against post-translational diseases such as diabetes, cancer, cardiovascular disease, and celiac disease, among others. Millets are beneficial for controlling blood pressure, blood sugar level, and thyroid function; however, despite these functional properties, millets consumption has declined. Utilizing millets and other staple food crops to develop alternative food sources has become a new area of focus for businesses in the food industry. In addition, millet consumption can help foster immunity and health, which is essential in strengthening our fight against malnutrition in children and adolescents. In this article, the authors examine the potential of millets in terms of their nutricereal qualities.

Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients

Introduction Major Thalassemia patients suffer from iron overload and organ damage, especially heart and liver damage. Early diagnosis and treatment with a chelator can reduce the complications and mortality of iron overload. Therefore, we aimed to investigate the biochemical and hematological predictors as an alternative and indirect indicator of iron deposition in heart and liver cells in comparison with the MRI T2* method as the gold standard. Material and method MRI T2* was evaluated in the heart and liver tissues of 62 major beta-thalassemia patients undergoing regular transfusion and chelator therapy. Biochemical and hematological factors were also measured, including serum ferritin, serum electrolytes, liver enzymes, hemoglobin, blood glucose, and serum magnesium. The correlation between these factors was assessed using statistical evaluations. Result Serum ferritin had a positive and significant correlation with liver siderosis based on MRI T2* (p-value = .015), and no significant association was observed with cardiac siderosis (p-value = .79). However, there was a significant positive correlation between cardiac iron deposition and fasting blood sugar level (p-value = −.049), and plasma level of liver enzymes (alanine aminotransferase (ALT) (p-value = .001), aspartate aminotransferase (AST ((p-value = .01)). Moreover, there was a significant negative correlation between cardiac iron overload and plasma magnesium level (p-value = .014). According to MRI T2*, there was no significant correlation between cardiac and hepatic iron overload (p value = .36). Conclusion An increase in blood sugar or liver enzymes and a decrease in serum magnesium was associated with an increase in cardiac iron overload based on MRI T2*. Liver iron overload based on MRI T2* had a significant correlation with serum ferritin.

Physiological responses to a changing winter climate in an early spring-breeding amphibian.

Climate change is swiftly altering environmental winter conditions, leading to significant ecological impacts such as phenological shifts in many species. As a result, animals might face physiological mismatches due to longer or earlier activity periods and are at risk of being exposed to late spring freezes. Our study points for the first time to the complex physiological challenges that amphibians face as a result of changing thermal conditions due to winter climate change. We investigated the physiological responses to a period of warmer winter days and sudden spring freeze in the common toad (Bufo bufo) by acclimating them to 4°C or 8°C for 48 h or exposing them to 4°C or -2°C for 6 h, respectively. We assessed the daily energy demands, determined body condition and cold tolerance, explored the molecular responses to freezing through hepatic tissue transcriptome analysis, and measured blood glucose levels. Toads acclimated to higher temperatures showed a higher daily energy expenditure and a reduced cold tolerance suggesting faster depletion of energy stores and the loss of winter acclimation during warmer winters. Blood sugar levels were higher in frozen toads indicating the mobilization of cryoprotective glucose with freezing which was further supported by changed patterns in proteins related to glucose metabolism. Overall, our results emphasize that increased thermal variability incurs physiological costs that may reduce energy reserves and thus affect amphibian health and survival. This might pose a serious threat to breeding adults and may have subsequent effects at the population level.

Hepatoprotective Effects of Curcumin on Liver Injury in Streptozocin-induced Diabetic Rats

Introduction: Type 2 diabetes mellitus is characterized by chronically elevated blood sugar levels associated with disruption of the inflammatory and oxidative state and dyslipidemia. Curcumin is a highly pleiotropic molecule with hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant properties. The aim of this study was to evaluate the effects of curcumin on the liver of streptozotocin-induced diabetic rats. Materials and Methods: Thirty-two adult male rats were used in the study. The rats were divided into four groups: Control (C), Diabetes (D), Curcumin (CUR), and Diabetes + Curcumin (D + CUR) (n = 8). The groups given curcumin were given 60 mg/kg curcumin by gavage once a day during the 14-day study period. At the end of the experiment, biochemical, stereological, histological, and immunohistochemical analyses were performed on blood and liver samples taken from rats sacrificed. Results: After curcumin treatment in diabetic rats, there was a significant decrease in blood glucose levels, hepatic markers, and levels of thiobarbituric acid reactive substances (P &lt; 0.01). Furthermore, a significant increase in enzymatic antioxidants such as superoxide dismutase, catalase, and glutathione peroxidase was observed after treatment (P &lt; 0.01). It was determined that curcumin decreased the apoptotic index and the number of dual-nucleated hepatocytes in the liver, and provided support for liver regeneration (P &lt; 0.01). Discussion and Conclusion: Based on the findings of this study, it can be concluded that curcumin has the potential to protect against hyperglycemia-induced oxidative stress and apoptosis in liver cells, and also induces regeneration in damaged liver.

Evaluating the Correlation of Fasting Blood Sugar, Glycated Hemoglobin with the Hearing Loss

Background and objectives: Hearing loss is one of the most prevalent disabilities. Factors that can be controlled are linked to hearing loss. Diabetes, which can potentially lead to hearing loss during cases of high blood sugar levels, appears to be a contributing factor to hearing loss. This study aimed to determine the relationship between fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) with hearing loss. Method: This was a cross-sectional study conducted on two groups: the study sample consisting of patients with both diabetes and hearing loss, and the control sample comprising non-diabetic individuals with hearing loss. The study was carried out at the Sabratha Residential Clinic, Surman Clinic Al-Kubra, and Surman General Hospital between April 12, 2022, and October 25, 2023. During this period, a questionnaire was prepared, and a "Pure Tone Audiometry" hearing test was performed in the planning room to assess the hearing status of participants in both the study and control groups. Results: The study involved 80 participants, of whom 44 (55%) were male and 36 (45%) were female, aged 25-65 years. Compared to the control group, the study group had significantly higher fasting blood sugar (FBS: 202.13 ± 48.13 vs. 81.38 ± 9.50, p&lt;0.001) and glycated hemoglobin (HbA1c: 9.48 ± 2.1 vs. 4.25 ± 0.59, p&lt;0.001) levels, The study group exhibited greater hearing impairment in the left ear (56.90 ± 22.94 vs. 44.40 ± 28.13, p=0.031), but the difference in right ear hearing loss was not statistically significant (53.33 ± 24.47 vs. 44.025 ± 28.41, p=0.121). HbA1c (r=0.239, p=0.027) and FBS (r=0.216, p=0.033) both showed significant positive correlations with hearing loss. Conclusion: This study found that type 2 diabetes mellitus adversely affects hearing, with sensorineural hearing loss positively correlating with HbA1c and FBS levels. These findings indicate that poor glycemic control is associated with an increased risk of hearing impairment in this patient population.

A Study of the Prevalence of Diabetic Retinopathy in Patients With Ischemic Heart Disease and Diabetes Mellitus.

Background Diabetes mellitus is one of the most important and common chronic diseases worldwide and is expected to increase in prevalence. Diabetic retinopathy (DR) is one of the most prevalent microvascular sequelae of diabetes mellitus (DM), and ischemic heart disease is a macrovascular sequela. This study was conducted to find out the relation between the degree of DR and ischemic heart disease severity in Indian patients. Materials and methods This cross-sectional, descriptive, hospital-based study was conducted in the ophthalmology department at Dr. D. Y. Patil Medical Hospital, Pune, Maharashtra, India, from September 2022 to June 2024. A total of 200 eyes from 100 patients who were diagnosed with cases of ischemic heart disease and diabetes mellitus were included in the study. Patients with corneal pathology like endothelial dystrophies, corneal degenerations, corneal scars, or trauma preventing good visualization of the posterior segment were excluded from the study. Patients with active uveitis, patients with a history of undergoing any previous vitreoretinal surgery or laser procedures, non-compliant patients, patients not willing to undergo the procedure, or those not consenting to the study were also excluded. Written informed consent was obtained from each patient. Data was entered in Microsoft Exceland statistical analysis was done using IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. As the continuous variables showed a skewed distribution, we used the Mann-Whitney test and the Kruskal-Wallis test to test the significance of the difference between continuous and categorical variables. A chi-square test was employed to check the association between categorical variables. Significance was assumed at an alpha error of 5%. Results The prevalence of diabetic retinopathy was found to be 95%. The mean age of patients with DR and patients with no diabetic retinopathy was 58.38 and 59.40 years, respectively, with the majority of the patients being in the age group of 60-69 years (46%). The majority of the patients were males (65%), while 35% were females. There was a significant association between the severity of diabetic retinopathy and the higher HbA1c levels, the use of insulin as a treatment modality, and the higher blood sugar levels in our study population. It was observed that the patients in our study with an ejection fraction of <40% had significantly higher severity of diabetic retinopathy in the form of PDR and high-risk PDR. The severity of the DR was directly correlated with the severity of IHD in our study, with most of the IHD patients with a 40-60% ejection fraction having moderate NPDR and patients with a >60% ejection fraction having mild or moderate NPDR. Conclusion The prevalence of diabetic retinopathy among the IHD patients with diabetes was 95% in our study, with moderate NPDR being the most common stage of DR seen among the patients. It was observed that more severe stages of diabetic retinopathy were seen in patients who were on treatment with insulin than in patients who were on treatment with OHA. Severe stages of diabetic retinopathy were associated with higher blood sugar levels (BSL) and higher glycated hemoglobin levels. In the present study, it was observed that a lower ejection fraction (<40%), which is a marker of reduced cardiac function, was associated with more severe stages of diabetic retinopathy.