Correlation between Glycated Hemoglobin, Extra cranial Carotid Artery Disease, Peripheral Arterial Disease in Type ll Diabetic Patients with Coronary Artery Disease

Abstract

Abstract Background Diabetes mellitus (DM) is the most common endocrine disorder where the body does not either produce enough insulin or has a resistance to the circulating insulin, and is characterized by high blood sugar levels over prolonged periods. DM is a growing global health issue. In 2000, DM affected an estimated 171 million people in the whole world increased on 2011 to more than 366 million people and expected to be more than 552 million by 2030. Aim of the Work to correlate between HBA1C, carotid, peripheral and coronary artery disease in type II DM patients. Patients and Methods This is an observational study conducted at the coronary care unit & coronary catheterization lab unit of National Institute of Diabetes and Endocrinology, Egypt. Its aim was to correlate between HBA1C, carotid, peripheral and coronary artery disease in type II DM patients. 122 patients with eligible criteria were recruited to the study after signing consent. A full history was taken from every patient, a full clinical examination, 12 lead-ECG, Echocardiography, Carotid duplex, ABI measurement, HbA1C and Invasive non emergent coronary angiography were done. Results Data was collected, tabulated, and analyzed, which revealed that carotid IMT in patients with HbA1C >7% was significantly higher than those with HbA1C<7, HbA1C had a significant positive correlation with carotid IMT, ABI was significantly lower in patients with HbA1C>7% compared to those with HbA1C<7%, ABI had a significant negative correlation with carotid IMT, Number of diseased coronary vessels was significantly higher in patients with higher HbA1C >7% compared to those with HbA1C>7%, ABI had a significant negative correlation with number of diseased coronary vessels and IMT had a significant positive correlation with number of diseased coronary vessels in patients with higher HbA1C >7% with no significant correlation in those with HbA1C<7%, HbA1C can significantly predict peripheral artery disease and carotid atherosclerosis. Conclusion HbA1C correlates significantly with Carotid atherosclerosis, PAD and CAD severity based on number of diseased coronary vessels in uncontrolled TIIDM patients. Also, PAD and carotid atherosclerosis correlate significantly with CAD severity based on number of diseased coronary vessels in uncontrolled TIIDM patients. Also, PAD correlates significantly with carotid atherosclerosis in uncontrolled TIIDM patients. HbA1C can significantly predict carotid artery disease and PAD.