This article considers an inverse eigenvalue problem for bisymmetric matrices under a central principal submatrix constraint and the corresponding optimal approximation problem. We first discuss the specified structure of bisymmetric matrices and their central principal submatrices. Then we study a special form for the matrix of independent eigenvectors for a bisymmetric matrix. Based on these, we give some necessary and sufficient conditions for the solvability of the inverse eigenvalue problem, and we derive an expression for its general solution. Finally, we obtain an expression for the solution to the corresponding optimal approximation problem.
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