Stomatitis In Children Research Articles

Creation Of Anti Stomatitis-S Gel in The Treatment Of Stomatits In Children

The most urgent problem of dentistry is diseases of the oral mucosa, both in adults and in children of all age groups. The oral cavity is an environment with a high potential for the development of inflammatory processes, since the mucous membranes are attacked by microorganisms in the first place. Stomatitis is a disease of the oral mucosa that occurs with an inflammatory reaction, which is characterized by all the classic signs of inflammation. The study of treatment methods is an integral factor in the development of relapses and the formation of chronic stomatitis in children

Efficacy of Platelet Gel in Children with Stomatitis during Chemotherapy

Abstract Introduction. Stomatitis (oral mucositis) is a very serious adverse effect of anticancer therapy, and it may exacerbate treatment outcomes as well as prognoses. Stomatitis is associated with pain during chewing and swallowing, causing discomfort and interfering with eating. It can also lead to weight loss and a delay in child growth and development. None of the numerous therapies used for stomatitis management can be considered universal or sufficiently effective. Allogeneic platelet gel, a formulation that adheres closely to mucosal lesions and is rich in growth factors, may be an effective treatment for accelerating the erosion-healing process. Methods. A prospective, open-label study on the efficacy of platelet gel used for the treatment of stomatitis in children during chemotherapy. Platelet gel was applied to oral mucosal lesions four times a day. Results. 28 patients with Grade II and Grade III stomatitis were enrolled in the study. The first day after applying platelet gel, 93% of patients reported relief from pain. Within 4 to 5 days, one degree of mucosal lesion regression was reported in 89% of patients, indicating a 3 to 5 day reduction in therapy compared to our previous experience. In only two patients did we observe mild adverse events in the form of a burning sensation. Conclusion. Platelet gel contributed to both pain reduction and acceleration of the oral mucosa healing process. It is a safe and effective therapy for children with stomatitis induced by chemotherapy.

Prevalence of Dental Diseases in Children with Digestive Tract Diseases

To study the prevalence of stomatitis among children with the background of chronic gastroduodenitis (CG). 74 children aged from 3 to 17 years old, who were in inpatient treatment during the 1st half of 2020. The patients' aged 5 to 16 years. Boys - 41.8%, girls - 58.2%. The duration of the disease in 45% from 1 to 5 years, in 55% it was 5 or more years. Symptoms of CG were characterized by pain (82.6%), dyspeptic (76%) and asthenovegetative (in 2/3) syndromes. In 65.6%, signs of poly hypovitaminosis and micronutrient deficiencies were found. According to the endoscopic examination, superficial (42.2%), erosive (31.8%), atrophic forms of gastritis (18.8%) were more common, other forms of CG were less common. Among the oral cavity pathologies, caries (20.2%), aphthous stomatitis and angular cheilitis (39.1%) were common. Chronic stomatitis prevailed (62.1%) compared with acute (37.9%). Mild was 14.8%, medium - 51.7%, severe - 10.3%. In the structure of stomatitis, the fibrous form was often (62%), less often necrotic (17.2%) and granulation and lichenoid form 10 3%. The etiological factor: herpes virus (24.1%), Candida (17.2%), bacterial (27.5%, often staphylococci, streptococci, Klebsiela, etc.), combined flora was in angular cheilitis (31,2%) Stomatitis in children with gastrointestinal tract pathology has more severe course. Success in the treatment and maintenance of health in different ages children. The work of a multidisciplinary team is required.

Tissue Optical Clearing in the Ultraviolet for Clinical Use in Dentistry to Optimize the Treatment of Chronic Recurrent Aphthous Stomatitis

The immersion optical clearing (OC) treatment with a highly concentrated glycerol solution has induced three new tissue windows in the UV spectral range of gingival tissues – from 200 to 250 nm, from 250 to 300 nm and from 300 to 400 nm. By combining the immersion OC technique in human tissues with UV-spectroscopy, it was possible to verify and study the major OC mechanisms – tissue dehydration and refractive index matching, and that the OC efficiency is higher in the deep-UV than in the visible-NIR range. Since all biological tissues present high scattering in the UV range, the presented technology, which basically reduces the strong light scattering in the UV range, has a broad application area in medicine. The effectiveness of the developed technology combining UV phototherapy and OC in application to treatment of aphthous recurrent stomatitis in children was demonstrated.

Changes in the spectrum of salivary cytokines in recurrent stomatitis in children

The concentration of the level of cytokines in saliva depends on the form of stomatitis, which is confirmed by the presence of a relationship between the concentrations of TNFα and IL-1β, and this relationship is direct and varies depending on the form of stomatitis, which indicates a violation of immunoregulatory mechanisms in chronic recurrent forms of stomatitis.

Transitional Features Of Acute Herpetic Stomatitis In Children And Modern Approaches To Treatment

Herpesviruses are widespread us in the human population. They capable of hitting almost everyone organs and systems, induce neoplastic static processes and development of atherosclerosis, have an adverse effect, and sometimes a fatal effect on the body nism of the fetus and newborns. The article presents characteristic peculiarities of herpetic stomatitis in children. It describes differential diagnostic symptoms. The treatment approaches are given depending on the severity degree of the disease.

Therapy of recurrent herpetic stomatitis in childrens with bronchial asthma

The work presents the results of a study of the effectiveness of the use of an immunomodulating agent for the treatment of recurrent herpetic stomatitis in children with bronchial asthma. The therapy of recurrent herpetic stomatitis was carried out in 67 children aged 1 to 16 years with bronchial asthma according to the scheme proposed by the authors using an immunomodulator. The immune status of patients before and after the therapy was assessed using the following indicators: the content of immunoglobulin (SIgA) in saliva, salivary lysozyme, an integrated indicator, the balance coefficient (Ksb). The results of the study showed that after the therapy, the incidence rates of recurrent herpetic stomatitis improved, the state of local immunity approached the group of healthy children. It is concluded that the proposed therapy for recurrent herpetic stomatitis in children with bronchial asthma gave a positive result and can be recommended for the treatment of this category of patients.

Photobiomodulation therapy for the management of recurrent aphthous stomatitis in children: clinical effectiveness and parental satisfaction.

Background This study aims to evaluate the effectiveness of the photobiomodulation therapy (PBMT) in the treatment of minor recurrent aphthous stomatitis (MiRAS) in children, in terms of pain relief, lesion size reduction and the parental satisfaction of the therapy. Material and Methods This randomized controlled study was carried out on 60 children with clinical diagnosis of MiRAS. Patients were randomized into two groups: group A receiving laser therapy and group B receiving sham therapy (placebo). Laser therapy (diode laser, λ: 645 nm) was administered on day 1 (T0) for three consecutive days. Patients were evaluated also on day 4 (T1), on day 7 (T2) and on day 10 (T3). Oral aphthous lesions size was assessed through a periodontal probe to measure the diameter length (mm); pain was evaluated through the Visual Analogue Scale (VAS); parental satisfaction was assessed through a questionnaire. Results The difference in the reduction of ulcers diameters between the two groups resulted statistically significant at T1 and at T2 (p<0.05). A statistically significant difference in pain reduction between two groups was found at T1 (p<0.05). No statistically significant difference between the two groups of parents was found as concerns the parental acceptance of the procedure and the discomfort for the need of multiple appointments. Conclusions PBMT is to be considered effective in the treatment of MiRAS in children and well- accepted by the parents of the children themselves. Key words:Ulcers, children, lasers

Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis.

The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings.

Recurrent Aphthous Stomatitis in Children: A Practical Guideline for Paediatric Practitioners.

Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal lesion affecting up to 25% of the population. The diagnosis is based on well-defined clinical characteristics, but the precise aetiology and pathogenesis remain unclear. The treatment of RAS should be based on the identification and control of possible predisposing factors. A wide range of topical medicaments is available as antiseptics, anti-inflammatory drugs and corticosteroids. The systemic treatment is indicated in patients with continuous and aggressive manifestation, which is extremely rare in children. The present article provides a review of the current concept and knowledge of the aetiology, pathogenesis, and management of RAS in the paediatric population.

Effect of Diode Laser combined with Hyaluronic Acid Gel in Treatment of Recurrent Aphthous Stomatitis in Children: Randomized Clinical Trial

Background: Recurrent Aphthous Stomatitis (RAS) is a painful rounded ulcer characteristic by erythematous margin and pseudo yellowish- gray membrane in its center. All forms of RAS have bad effects on quality of life that interfere with daily activities. Hyaluronic acid has essential part in tissue hydrodynamics, cell migration, proliferation and differentiation. It shows an anti-inflammatory role so; it prevents tissue destruction and helps in tissue healing. Low level laser therapy is recognized with various terminologies such as “biostimulator,” and “cold laser,” It has role in the management of RAS, it has a wide spectrum of clinical applications which include herpes labialis, angular cheilitis, trismus, paresthesia, dentin hypersensitivity, temporomandibular joint pain, and in the postoperative phase.Materials and Method: Forty five normal healthy males and females children aged from (4-10 years) suffering from aphthous lesions were used in this study. Children were examined in Outpatient clinic pediatric Dentistry Department, Faculty of Dentistry, Suez canal University by a clinician. Each patient had one minor RAS of less than 72 h duration or two nearby minor aphthous lesions of less than 72 h at the same side of oral cavity. Patients were evenly divided into three groups (15 patients in each) with the method of simple randomization, Patients of group I were treated with topical application of hyaluronic acid gel , those of group II were treated with diode laser and group III patients were treated with diode laser followed by topical application of hyaluronic acid gel. The patients were evaluated at (0, 2nd, 4th and 6th) days, for measuring ulcer size and pain score. Results: At the 2nd, 4th and 6th days there was statistical significance decrease in mean size of the ulcer of group III when compared to both groups (I) and (II) . On other hands, at days 2 and 6 there was statistical significance decrease in mean of pain score in group III when compared to group I. There was also statistical significance decrease in mean of pain score in group II when compared to group I at the 4th day of evaluation.Conclusion: Hyaluronic acid gel combined with diode laser are effective in treatment of RAS.

Analysis of etiopathogenetic and clinical features for chronic recurrent aphthouse stomatitis in children with rheumatic diseases

The aim of the study was to increase the level of diagnosis and treatment of chronic recurrent aphthous stomatitis in children with rheumatic diseases. We carried out a dental examination and treatment of 316 children with rheumatic diseases, 67 of them had chronic recurrent aphthous stomatitis. In the course of the study the authors determined and analyzed the etiological, pathogenetic and clinical features of the course of chronic recurrent aphthous stomatitis in children with rheumatic diseases. The study describes the examples of aphthousstomatitis of varying severity. Chronic recurrent aphthousstomatitisis an integralsymptom of a somatic disease, itstreatment requires the interaction of many specialists: dentist, pediatrician, rheumatologist, gastroenterologist, otolaryngologist, etc.

Recurrent stomatitis in children

Recurrent stomatitis in children

Nursing research progress on chemotherapy-induced stomatitis in children with malignant tumor

The incidence of chemotherapy-induced stomatitis is very high in the pediatric patients with malignant tumor. The pain, eating disorders and malnutrition caused induced by stomatitis influence children's quality of life seriously. They even influence the progress of chemotherapy regimens. This paper summarizes the causes, risk factors, the grading standard, prevention and nursing measures of chemotherapy-induced stomatitis. It indicates that the prevention measures should be combined with the treatment for chemotherapy-induced stomatitis at the same time. Medical staff should evaluate the oral cavity problems of the pediatric patients and make oral nursing plans for every patient according to their chemotherapy regimens, in order to accelerate the healing process of chemotherapy-induced stomatitis. Key words: Review; Malignant tumor; Chemotherapy-induced stomatitis; Oral nursing; Mouthwash

Management of Recurrent Aphthous Stomatitis in Children.

Recurrent oral ulceration is common and may present in childhood. Causes of recurrent oral ulceration are numerous and there may be an association with underlying systemic disease. Recurrent aphthous stomatitis (RAS) is the most common underlying diagnosis in children. The discomfort of oral ulcers can impact negatively on quality of life of a child, interfering with eating, speaking and may result in missed school days. The role of the general dental practitioner is to identify patients who can be treated with simple measures in primary dental care and those who require assessment and treatment in secondary care. Management may include topical agents for symptomatic relief, topical corticosteroids and, in severe recalcitrant cases, systemic agents may be necessary.

Homeopathy in the paediatric population

Homeopathy in the paediatric population

Helicobacter pylori (HP) may be involved in the pathogenesis of recurrent aphthous ulcers in children and adolescents

Fritscher AM, Cherubini K, Chies J, Dias AC. Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents. J Oral Pathol Med 2004;33(3):129-32. 3b Is HP involved in the etiology of recurrent aphthous ulcers in children and the adolescent population? Information not available Case-control study

Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents.

The recurrent aphthous stomatitis (RAS) is a common disease with unknown etiology. Helicobacter pylori has been shown to be the causative factor in peptic ulcers. Considering the similarities of histologic features between gastric and oral ulceration, we studied the possible involvement of H. pylori in the development of RAS. A total of 105 children and adolescents were investigated--53 patients with RAS (case group) and 52 patients without lesions (control group). Specimens obtained by swabbing RAS lesions, intact oral mucosa, and dental plaque were submitted to a polymerase chain reaction (PCR)-based assay. Helicobacter pylori was present in six patients of the case group (11.3%) and in three of the control group (5.8%). When the site of infection was studied, 9.4% of the RAS lesions were PCR positives. In the case group and control group, 5.7 and 1.9% of the specimens from dental plaque, respectively, and 5.7 and 3.8% of the specimens from the intact oral mucosa, respectively, were PCR positives. There was no association between RAS lesions and infection of the oral cavity by H. pylori in children and adolescents (P = 0.254).

A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL s� in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation

Stomatitis is a common consequence of chemotherapy and a condition for which there is little effective treatment. Although the management of patients with other chemotherapy-related toxicities has improved in recent years, the incidence of stomatitis is increasing because of more intensive treatment and is often a dose limiting factor in chemotherapy. The authors assessed the efficacy of a homeopathic remedy, TRAUMEEL S(R), in the management of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.A randomized, placebo-controlled, double-blind clinical trial was conducted in 32 patients ages 3-25 years who had undergone allogeneic (16 patients) or autologous (16 patients) stem cell transplantation. Of the 30 evaluable patients, 15 were assigned placebo, and 15 were assigned TRAUMEEL S both as a mouth rinse, administered five times daily from 2 days after transplantation for a minimum of 14 days, or until at least 2 days after all signs of stomatitis were absent. Stomatitis scores were evaluated according to the World Health Organization grading system for mucositis.A total of five patients (33%) in the TRAUMEEL S treatment group did not develop stomatitis compared with only one patient (7%) in the placebo group. Stomatitis worsened in only 7 patients (47%) in the TRAUMEEL S treatment group compared with 14 patients (93%) in the placebo group. The mean area under the curve stomatitis scores were 10.4 in the TRAUMEEL S treatment group and 24.3 in the placebo group. This difference was statistically significant (P < 0.01).This study indicates that TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.

Disseminated herpes simplex virus infection. Its pathogenesis based on virological and pathological studies in 33 cases.

THE NATURAL history of herpes simplex virus infection, which has been well established since the virus was first incriminated as a cause of stomatitis in children, 1 was reviewed recently. 2,3 Primary infection occurs most often in a subclinical or clinically unrecognized form in early childhood. If the primary infection is overt it may present in a variety of ways and recovery usually follows, but occasionally permanent damage or death results. The epidemiology of fatal disseminated herpes simplex virus infection occuring in children after the neonatal period has been reviewed and the association with malnutrition and measles stressed. 4 Little is known about the pathogenesis of this fatal form of infection which was initially recognized in Cape Town, South Africa in 1957. 5 Detailed virological and pathological studies have been carried out in 33 cases, including one neonate, seen in the subsequent nine years, and results of these studies are