After having dealt with the growing number of infected health workers in the province of Hubei in China, it was concluded that the most important link in the fight against SARS-CoV-2 infection was the proper and responsible management of health personnel. The aim of the paper is to is to determine whether, during the pandemic, human resources were well managed in state health institutions. Discovering the critical points of health workers management is very important in order to raise the overall quality of health services in the future emergency situations. A total of 150 respondents employed in COVID hospitals in Belgrade and Loznica took part in this research. The results of the research obtained using the chi-square test, showed that the received necessary information at the beginning of the pandemic, training courses on the use, removal, putting on and disposal of protective equipment, and psychological support of the authorities significantly related with the perception of the safety of health workers in state health institutions. Management of health workers should be at a high level, with a special emphasis on improving the management of the health of employees and their safety at work.