Gypsum plasterboard that incorporates various combinations of polyurethane foam waste and polypropylene fibers in its matrix is studied. The prefabricated material was characterized in a series of standardized tests: bulk density, maximum breaking load under flexion stress, total water absorption, surface hardness, thermal properties, and reaction to fire performance. Polypropylene fibers were added to the polyurethane gypsum composites to improve the mechanical behavior of the plasterboard under loading. The results indicate that increased quantities of polymer waste led to significant reductions in the weight/surface ratio, the mechanical strength and the surface hardness of the gypsum, as well as improving its thermal resistance. The polypropylene fibers showed good adhesion to the polymer and the gypsum matrix, which enhanced the mechanical performance and the absorption capacity of these compounds. The non-combustibility test demonstrated the potential of the new material for use in internal linings.