The leading direction in the study of the so-called non-motor manifestations of Parkinson's disease (PD) is associated with the assessment of structural and functional changes in the organ of vision. Proceeding from the neurodegenerative nature of the disease, on the one hand, and the possibility of an objective in vivo assessment of both functional and structural changes in the corneal nerve fibers (NVR), on the other hand, the assessment of the state of thin myelin-free NVR in PD seems promising. Purpose of the study. Analysis of changes in the course and structure of NVR in the early stages of PD based on an objective algorithm of in vivo confocal microscopy (IVCM). Material and methods. The study was conducted in a group of 26 patients aged 39 to 69 years with a verified diagnosis of Parkinson's disease. In addition to the standard neurological and ophthalmological examination, all patients underwent IVCM using an HRT III device with a special corneal attachment Cornea Rostock, followed by processing of the obtained images using the author's analysis algorithm. Results. A significant decrease in the directional anisotropy coefficient and an increase in the directional symmetry coefficient of the NVR were found (average values 3.15±1.08 and 0.92±0.04, respectively). Normally, in an identical age range, these indicators are 3.5±0.85 and 0.86±0.11, respectively. In addition, qualitative structural changes were also noted, which consisted in an increase in the number of branches from the main nerve trunks, an increase in the tortuosity of the NVR, multidirectionality and "clearness". In 19 cases, the presence of macrophages, Langerhans dendritiform cells, was detected, the presence of which is an indirect sign of the inflammatory process. Conclusion. The preliminary nature of the results obtained in this work and the need for further research in this direction are associated, on the one hand, with a small sample of observations, and, on the other hand, with the use, due to the need, due to the lack of initial data, of the condition assessment criterion not based on a comparative analysis with conditionally normal age indicators. In the future, in order to address the issue of the specificity of changes in NVR and the possibility of using these changes as a marker of PD progression, dynamic studies are required, which involve the identification of the presence or absence of a correlation between the stage of the disease, the results of known monitoring methods (for example, electromyography) and quantitative indicators of the state of NVR. Key words: Parkinson's disease, corneal nerve fibers, laser confocal microscopy of the cornea.